Coumarins

5,7-Dimethoxycoumarin is a naturally occurring coumarin derivative, which is primarily sourced from various plant species, most notably those belonging to the Apiaceae and Rutaceae families. This compound is characterized by the presence of methoxy groups at the 5 and 7 positions on the coumarin core structure. These structural features contribute to its biological activity by influencing its interaction with various biomolecular targets. The mode of action of 5,7-Dimethoxycoumarin involves the modulation of enzymatic pathways and cellular processes, including its role as an inhibitor of certain protein kinases and enzymes involved in oxidative stress pathways. This makes it a subject of interest in the study of pharmacological and therapeutic interventions targeting oxidative stress and related diseases. In terms of its applications, 5,7-Dimethoxycoumarin is used in scientific research to explore its potential therapeutic effects. It has been studied for its antioxidative, anti-inflammatory, and anticancer properties. The compound's ability to modulate biological pathways makes it a valuable tool in drug discovery and development, particularly in the context of diseases associated with oxidative damage and inflammation.

M04132 - 4-Methylumbelliferyl beta-D-glucopyranoside

Daphnetin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Osthole is a coumarin derivative, which is a type of natural compound. It is predominantly sourced from the Cnidium monnieri plant, as well as other Apiaceae family members. Osthole exerts its effects primarily through modulation of various molecular pathways, including the suppression of inflammatory mediators and the modulation of calcium channels, which results in vasodilation and various other physiological effects. Osthole has garnered attention for its extensive range of potential therapeutic applications. It exhibits significant anti-inflammatory and antioxidant properties, making it a candidate for research in treating inflammatory and oxidative stress-related conditions. Moreover, its potential as an anti-cancer agent is under exploration, due to its ability to induce apoptosis and inhibit tumor growth. Additionally, osthole shows promise in the areas of neuroprotection, cardiovascular health, and bone health, offering a spectrum of possibilities for future pharmacological development. Scientists are particularly interested in its multifaceted biological activities, which open new avenues for therapeutic innovation.

Lactone

Isobergapten is a naturally occurring furanocoumarin, which is primarily derived from plants in the Apiaceae family, such as celery and parsley. The compound is structurally characterized by its fused furan and coumarin rings. It exerts its effects through its ability to interact with cellular enzymes and DNA, often influencing photodynamic processes. This interaction can result in modifications to DNA replication and transcription, making it a compound of interest in photochemotherapy and photobiology. In various scientific applications, isobergapten is studied for its potential role in modulating biological pathways, particularly those involved in skin disorders and cancer. Its ability to cause cellular apoptosis and inhibit proliferation through phototoxic mechanisms places it at the center of research on skin treatments and anticancer agents. Furthermore, its role in traditional and herbal medicine as a component influencing pigmentation and immune response continues to be of significant interest. Isobergapten's unique mode of action makes it a valuable subject of study in the exploration of novel therapeutic agents.

Applications A labelled metabolite of 7-Ethoxycoumarin and Coumarin. Useful as a pharmacokinetic standard in metabolic studies. References Blankson, E., et al.: Biochem. Pharmacol., 42, 1241 (1991), Steensma, A., et al.: Xenobiotica, 24, 893 (1994), Fisher, R., et al.: Toxicol. Methods, 5, 99 (1995), Ekins, S., et al.: Drug Metab. Dispos., 24, 990 (1996)

7-Prenyloxyumbelliferone is a natural coumarin derivative, which is primarily sourced from plants belonging to the Rutaceae and Apiaceae families. This compound exhibits a range of biological activities, including anti-inflammatory, antioxidant, and antimicrobial properties. The mode of action of 7-Prenyloxyumbelliferone involves the modulation of specific enzymes and signaling pathways, such as the inhibition of cyclooxygenase and lipoxygenase, and the scavenging of free radicals, which collectively contribute to its pharmacological effects. The applications of 7-Prenyloxyumbelliferone are diverse, encompassing both research and potential therapeutic uses. In scientific research, it serves as a valuable tool for studying the biological pathways associated with inflammation and oxidative stress. Additionally, its antimicrobial properties make it an interesting candidate for further exploration in the development of novel antimicrobial agents. The compound's unique chemical structure also lends itself to studies focused on structure-activity relationships, aimed at designing derivatives with enhanced efficacy and specificity.

Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.

Auraptene analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Rutaretin is a polyphenolic compound, which is a derivative of natural flavonoids extracted from plant sources. It functions primarily as an antioxidant by scavenging free radicals and inhibiting oxidative stress at the cellular level. Its molecular structure allows it to interact with reactive oxygen species, mitigating the damaging effects on cellular components such as DNA, proteins, and lipids. This compound is of significant interest in the scientific community due to its potential therapeutic applications. Rutaretin’s antioxidant properties are being explored for protective roles in neurodegenerative diseases, cardiovascular conditions, and certain types of cancer. Its ability to stabilize cellular environments and modulate enzymatic pathways further underscores its relevance in research focused on aging and chronic inflammatory diseases. In recent studies, Rutaretin has shown promise in enhancing cellular resilience against oxidative damage, thus making it a candidate for further investigation in both pharmacological formulations and as a dietary supplement in clinical settings. Its continued exploration could contribute to the development of novel therapies aimed at mitigating oxidative stress-related pathologies.

Lactone

Dimethylfraxetin (6,7,8-Trimethoxycoumarin) is a Carbonic anhydrase inhibitor(Ki:0.0097 μM)

1. Praeruptorin B can inhibit tumor promoter induced phemonenon in vitro.

Decursidin is a chemical compound, classified as a coumarin derivative, which is a bioactive constituent derived from the roots of the Angelica gigas plant. This compound is prominent for its pharmacological activities, attributed to its distinct chemical structure. The source of Decursidin, Angelica gigas, is predominantly found in East Asia and has been a focal point of traditional medicine. The extraction and isolation of Decursidin involve advanced chromatographic techniques to ensure purity and efficacy for research purposes. Decursidin functions primarily through modulating various cellular pathways. It exhibits potential anti-inflammatory, anti-cancer, and neuroprotective properties, largely by interacting with signaling cascades and influencing the expression of specific genes. This compound can inhibit pro-inflammatory cytokines and may induce apoptosis in certain cancer cell lines. In terms of uses and applications, Decursidin is under investigation for its therapeutic potential in treating inflammatory diseases, certain cancers, and neurodegenerative disorders. It is an area of active research, and further studies are needed to fully understand its mechanisms and therapeutic viability. Researchers continue to explore its applications in drug development, with a focus on its efficacy and safety profiles.

M04120 - 4-Methylumbelliferyl N-acetyl-beta-D-galactosaminide

Neoglycyrol shows some cardioprotective effects .

Praeruptorin C/E relaxes arteries, reduces heart contractility, acting like calcium blockers. D/E protect mice from acid lung injury by halting PMNs and IL-6.

(±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation.

Lactone

Ent-toddalolactone is a natural compound belonging to the coumarin group, derived from amphotericin. It has anti-inflammatory and anti-cancer activity.

Scoparone is a bioactive natural compound, which is primarily derived from plants in the Rutaceae family, such as Artemisia species. It is a coumarin derivative, known for its therapeutic properties due to its diverse biological activities. The mode of action of scoparone is multifaceted, involving the modulation of various enzymes and signaling pathways. It acts as an inhibitor of cytochrome P450 enzymes and influences pathways involving nitric oxide and reactive oxygen species, contributing to its anti-inflammatory and hepatoprotective effects. Scoparone's uses and applications are extensive in the fields of pharmacology and biochemistry. It is actively researched for its potential in treating liver-related disorders, such as hepatic fibrosis and jaundice, due to its ability to modulate enzyme activity and reduce oxidative stress. Additionally, scoparone exhibits significant anti-inflammatory and antioxidant properties, making it a topic of interest for treating conditions characterized by excessive inflammation. Furthermore, its role as a model compound for studying coumarin derivatives enhances its value in scientific research, expanding its relevance beyond purely therapeutic applications.

Peucedanol methyl ether is a bioactive natural compound, which is derived from certain species of the Peucedanum genus, commonly found in various geographic regions. This compound is predominantly obtained from natural extracts through advanced chromatographic techniques. Its molecular structure is characterized by its functional groups, which contribute to its biological activities. The mode of action of Peucedanol methyl ether involves interacting with specific cellular targets, which can modulate biochemical pathways. This interaction often leads to biological effects such as anti-inflammatory, anticancer, or antimicrobial activities, depending on the cellular context and the specific targets involved. In scientific research, Peucedanol methyl ether is explored for its potential therapeutic applications. Researchers investigate its effects on cellular processes to understand its efficacy and mechanisms in disease models. The comprehensive study of this compound aids in elucidating its role in pharmacology and toxicology, contributing to the development of novel therapeutic agents. Moreover, its structure-activity relationship can be analyzed to design derivatives with enhanced bioactivity or reduced toxicity.

Lactone