Coumarins

Demethyldaphnoretin-7-O-glucoside, from Daphne oleoides, treats malaria, rheumatism, and heals wounds in Turkish medicine.

M01892 - Boc-Lys(Ac)-AMC

Scopolin is a coumarin glucoside, which is derived from the plant secondary metabolism. It originates predominantly from species within the Solanaceae family, including tobacco and potato plants. Its biosynthesis involves the conversion of scopoline, a precursor molecule, through glucosylation. This process is catalyzed by glucosyltransferases, which facilitate the attachment of a glucose moiety. Scopolin functions primarily as a phytoalexin, engaging in defense mechanisms within plants. It accumulates in response to pathogenic attack or environmental stressors, acting to inhibit the growth of pathogens through antimicrobial properties. Additionally, scopolin participates in lignin biosynthesis, contributing to cell wall fortification, which enhances the structural integrity and resistance of the plant. Research into scopolin has unveiled its role in plant defense signaling pathways and potential applications in agricultural biotechnology. By bolstering plant resilience to diseases and environmental stresses, scopolin can contribute to more sustainable crop production practices. Its implications for enhancing plant viability under stress conditions remain a significant interest in advancing agricultural science.

Lactone

Demethylsuberosin is a naturally-occurring compound, specifically a coumarin derivative, which is often extracted from plants. It originates from numerous botanical sources, including the family Rutaceae, where it serves as a secondary metabolite. Its mode of action involves the inhibition of fungal and bacterial growth, achieved by disrupting the integrity of microbial cell walls and interfering with their replication processes. The compound’s antimicrobial properties have made it a subject of interest in various scientific studies focusing on its potential applications. Demethylsuberosin has been researched for its use in agriculture, where it could serve as a biopesticide to control plant pathogens. Moreover, its antifungal attributes suggest possible applications within pharmaceuticals for treating fungal infections. Beyond its role in inhibiting pathogens, it is of interest for its involvement in biochemical pathways and potential impact on human health. Further exploration and characterization of demethylsuberosin could advance our understanding of its full range of applications and efficacy.

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7-Methoxy-8-hydroxy-4-phenylcoumarin is a coumarin derivative, a type of organic compound characterized by a benzopyrone structure. This compound is typically derived from natural plant sources or synthesized in laboratory settings. Its structural features, such as the methoxy and hydroxy groups, are integral to its potential biological activity. The mode of action of 7-methoxy-8-hydroxy-4-phenylcoumarin may involve interaction with various biological pathways. Its mechanism often includes antioxidant activities, where it may scavenge free radicals and mitigate oxidative stress, a process linked to numerous degenerative diseases. This compound has a range of uses and applications in scientific research. It is often explored for its potential therapeutic benefits in pharmacological studies. Research into this molecule can provide insights into the development of novel treatments for conditions related to oxidative damage. Additionally, its unique structure allows for exploration in material science, offering opportunities for innovation in polymer development or as fluorescent markers in imaging techniques. Researchers continue to investigate its multifaceted roles across diverse scientific domains.

Isoscopoletin (7-Methoxyesculetin) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 6, 7-dimethoxy-2h-chromen-2-one.

7-Ethoxycoumarin is a fluorescent substrate used in biochemical research, which is derived synthetically. It undergoes biotransformation primarily via oxidative dealkylation, catalyzed by cytochrome P450 enzymes, resulting in the formation of 7-hydroxycoumarin. By monitoring the fluorescent 7-hydroxycoumarin, researchers can assess enzymatic activity and study metabolic pathways. This compound is pivotal in studies involving xenobiotic metabolism, toxicology, and pharmacokinetics. Due to its capability to exhibit fluorescence, it is an essential tool in in vitro assays inspecting enzyme activity, especially in the context of drug metabolism and discovery. Its application extends to evaluating the effect of various inhibitors and inducers on cytochrome P450 enzymes, providing insight into potential drug-drug interactions and metabolic rates.

Geiparvarin is a cytotoxic compound, which is a plant-derived chemical with notable bioactivity. It is sourced from the roots of the Daflon plant, known for various natural compounds with potential therapeutic effects. Geiparvarin acts by interfering with cellular processes, leading to apoptosis in malignant cells. This mode of action is particularly significant in the study and development of anticancer therapies. The compound's effectiveness in inducing cell death in cancer cells has made it a subject of interest in oncological research. Scientists are exploring its mechanisms and potential in drug development aimed at targeting specific cancer types. While extensive research is still ongoing to fully understand its applications and side effects, Geiparvarin holds promise for future therapeutic use, warranting further studies to explore its efficacy and safety profiles.

Daphnetin dimethyl ether is a synthetic chemical compound, which is a derivative of the naturally occurring coumarin scaffold. It is primarily sourced through chemical synthesis rather than extraction from natural compounds, allowing for precise control over purity and structural modifications that are otherwise challenging to achieve through natural means. This compound acts through various biological pathways, often as a modulator of enzyme activity. Its mode of action includes the inhibition of specific kinases and other enzymatic targets, making it a molecule of interest for its potential anti-inflammatory, antioxidant, and anticancer properties. These molecular interactions underscore its capabilities to interfere with pathological states that involve oxidative stress and aberrant cell signaling. Daphnetin dimethyl ether is utilized in research settings, predominantly in the investigation of therapeutic strategies aimed at mitigating inflammatory diseases and certain types of cancer. Its applications extend to the study of cellular processes and signaling pathways, constituting an important tool in the exploration of novel drug targets and mechanistic insights into disease progression. Its utility in clinical settings is still in the exploratory phase, warranting further investigation into its pharmacodynamics and therapeutic potential.

(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) is an antineoplastic agent.

Columbianetin acetate can be absorbed in whole intestinal sections and colon is the best absorption region of whole rat intestines.The increase of columbianetin acetate concentration has no effect on absorption kinetics,the absorption of columbianetin acetate is a passive diffusion process, not pH-dependent.

Lactone

Acetyl columbianetin is a natural compound, which is a type of secondary metabolite derived primarily from plant sources. This compound is part of a broader category of phytochemicals known for their diverse bioactive properties. Acetyl columbianetin is specifically sourced from certain species within the Apiaceae family, commonly found in traditional medicine. The mode of action of Acetyl columbianetin is linked to its ability to interact with various biological pathways, notably through antioxidant and anti-inflammatory mechanisms. These interactions can modulate cellular processes and contribute to the compound's therapeutic potential. The efficacy of the compound is often attributed to its chemical structure, which facilitates interactions with cellular targets. The uses and applications of Acetyl columbianetin are of significant interest in scientific research, particularly for its potential in pharmaceutical and therapeutic developments. Studies have explored its effects in various models of disease, focusing on its capacity to act as a potential anti-inflammatory agent. Additionally, its role in combating oxidative stress positions it as a candidate for further investigation in the context of chronic diseases and age-related conditions. Scientists are continuously exploring its pharmacokinetic properties and bioavailability to harness its full potential within drug development frameworks.

Lactone

cis-Isokhellactone is a bioactive compound that belongs to the class of sesquiterpene lactones, which is isolated from plants in the genus Khella. With a well-characterized molecular structure, this compound exhibits significant binding affinity for cellular targets that are crucial in the regulation of cell proliferation and apoptosis. The mode of action involves the modulation of signaling pathways involved in cell cycle regulation and the induction of apoptosis in neoplastic cells. Recent studies have demonstrated the potential of cis-Isokhellactone in antitumor applications, particularly against certain cancers, by interfering with cellular processes specific to malignant cells, offering a valuable tool for biochemical and pharmacological research. As a result, it is under investigation both as a standalone compound and as a potential complement in combination therapies. Its ability to selectively target tumor cells offers a promising avenue for developing more effective and less toxic cancer treatments.

3-Cyano-7-ethoxycoumarin is cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 .

Hydrangetin (7-Hydroxy-8-methoxycoumarin) is a small molecule compound from Daphne papyracea var that inhibits platelet aggregation.

4-Methylesculetin is a coumarin derivative, which is a type of organic compound. This compound is primarily sourced from various plant species, where it occurs naturally as a secondary metabolite. Known for its bioactive properties, 4-Methylesculetin exhibits significant antioxidant activity by scavenging free radicals and protecting against oxidative stress. The mode of action of 4-Methylesculetin involves inhibiting reactive oxygen species and modulating signaling pathways involved in cellular stress responses. Additionally, it may interact with various enzyme systems, contributing to its potential therapeutic effects. In terms of uses and applications, 4-Methylesculetin is extensively studied in the field of biomedical research. It is explored for its potential in developing treatments for conditions related to oxidative stress, such as neurodegenerative diseases and cardiovascular disorders. Furthermore, its ability to modulate inflammatory responses makes it a candidate for anti-inflammatory therapies. Researchers are investigating its full spectrum of biological activities to better understand its role in therapeutic interventions.

Salvianolic acid C has antioxidant effect, it exhibits potent XOD inhibitory activity with an IC(50) of 9.07 μM. Salvianolic acid C enhances the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects.

4-Methylumbelliferone: coumarin derivative, used as spasmolytic, choleretic, light-protective agent, and to detect nitric acid.

5-Methoxypsoralen is a light-activated compound, which is a naturally derived organic substance found in certain plants, particularly from the Apiaceae family. This compound functions as a furocoumarin that interacts with DNA through photoactivation, forming cross-links upon exposure to ultraviolet A (UVA) light. These cross-links disrupt DNA replication, ultimately inhibiting cell proliferation. The primary applications of 5-Methoxypsoralen are in the field of dermatological therapy, specifically in photochemotherapy (PUVA therapy) for treating conditions such as psoriasis, vitiligo, and certain skin lymphomas. The compound's efficacy is derived from its ability to sensitize the skin to UVA radiation, leading to therapeutic effects through controlled cellular damage and modulation of the immune response. Due to its ability to influence cellular processes, 5-Methoxypsoralen is utilized under strict clinical protocols to balance its therapeutic benefits with potential toxicities, making it an important tool in the management of skin disorders.

Umbelliferone-3-carboxylic acid is a coumarin derivative, which is a type of natural or synthetic organic compound often utilized in biochemical research. It is sourced from modifications of natural coumarins, which are typically isolated from plants belonging to the Apiaceae family, such as parsley, celery, and carrots. This compound functions by interacting with cellular enzymes, providing a fluorescent probe that aids in the investigation of enzymatic activities and pathways. The applications of Umbelliferone-3-carboxylic acid are primarily within research settings, where it is used to study enzyme kinetics and inhibitor screening. This makes it a valuable tool in the development of pharmaceuticals and in the understanding of metabolic processes. Its ability to fluoresce under specific conditions allows researchers to analyze the dynamics of enzyme interactions in real time, offering insights into biological mechanisms that are fundamental to drug development and biochemistry.

Wedelolactone analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Psoralen (Ficusin) is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.

Bergapten is a naturally occurring furanocoumarin, which is derived from the essential oils of citrus fruits, such as bergamot. It is recognized for its photosensitizing properties due to its ability to interact with DNA upon exposure to ultraviolet (UV) light. The mode of action involves the formation of monoadducts with pyrimidine bases in DNA, which can lead to cross-linking and ultimately disrupt DNA replication and transcription. Bergapten's photosensitizing ability finds utility in phototherapy, notably in the treatment of skin conditions such as psoriasis and vitiligo. By inducing controlled skin erythema and resultant melanogenesis, it aids in repigmentation processes. Additionally, it serves as a research tool in studying DNA interactions and cellular responses to DNA damage. While its photosensitive nature is invaluable in therapeutic contexts, caution is warranted due to the potential for phototoxicity, necessitating careful monitoring in clinical applications. The compound's intricate role in influencing cellular pathways underscores its relevance in both therapeutic and research settings.

Iso-oxypeucedanin is a naturally occurring furanocoumarin compound, which is isolated from various plant species, particularly those belonging to the Apiaceae family. It exhibits a range of biological activities, primarily attributable to its structural properties that allow it to interact with various molecular targets. The mode of action of iso-oxypeucedanin involves the modulation of enzyme activities and the inhibition of cell proliferation. Studies have shown that it can interfere with metabolic pathways and oxidative stress mechanisms within targeted cells. Its ability to act as a photosensitizer also contributes to its functionalities, particularly in the induction of cell apoptosis under specific conditions. Iso-oxypeucedanin is mainly used in research exploring its potential therapeutic effects and pharmacological properties. It has been investigated for its anticancer, antimicrobial, and anti-inflammatory effects. Additionally, it serves as a tool in studying plant-animal and plant-environment interactions due to its natural occurrence in certain plant families. Its diverse biological activities make it a compound of interest in the development of new therapeutic agents and in the understanding of plant-derived bioactive substances.

Meranzin, a bioactive from TCM CSS, targets alpha 2-adrenoceptor, affects AMPA-ERK1/2-BDNF pathway, and may prevent atherosclerosis and depression.

Umbelliferone analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Decursinol is a coumarin derivative, which is sourced from the roots of the plant Angelica gigas, commonly found in East Asia. The compound is recognized for its biochemical properties, specifically as a secondary metabolite in the umbelliferous family. Its mode of action involves the inhibition of key inflammatory pathways, notably through the suppression of pro-inflammatory cytokines and enzymes such as COX-2 and NF-κB. This molecular interaction effectively reduces inflammatory responses at the cellular level. The use of Decursinol spans various scientific applications, primarily focusing on its potential therapeutic effects in treating inflammatory-related conditions. Research indicates significant promise in conditions such as arthritis, neuroinflammation, and other chronic inflammatory diseases. Its ability to mitigate oxidative stress further accentuates its relevance in neuroprotective studies. As ongoing research continues to elucidate its mechanisms and expand its applications, Decursinol represents a promising candidate in the development of novel anti-inflammatory therapeutics.

Isoscopoletin is a naturally occurring coumarin derivative, which is typically sourced from various plants, including some medicinal herbs. This compound is found in a variety of plant species, where it plays a role in the plant's defense mechanisms against pathogens. It is known for its characteristic chemical structure that belongs to the coumarin family, which is widespread in the plant kingdom. The mode of action of Isoscopoletin involves multiple biochemical pathways. It has been observed to exhibit antioxidative properties, likely by scavenging free radicals and modulating oxidative stress pathways. Additionally, Isoscopoletin may interact with cellular signaling pathways, potentially influencing inflammatory responses and enzyme activities. The applications of Isoscopoletin are diverse, particularly in the field of pharmacological research. It has been the subject of studies aiming to explore its potential therapeutic benefits, including anti-inflammatory, antimicrobial, and antioxidant activities. Researchers are also interested in its role in regulating metabolic processes and its possible use in developing new therapeutic agents. Continued studies are essential to fully elucidate its biological mechanisms and potential applications in medicine.

Lactone

Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.