Coumarins

3-Hydroxycoumarin is a coumarin derivative, which is a type of organic compound with significant pharmacological interest. It is derived from the parent structure of coumarin, naturally found in various plant sources such as tonka beans and sweet clover. Its molecular structure includes a hydroxyl group added at the third position of the coumarin backbone, conferring distinct chemical properties. The mode of action of 3-Hydroxycoumarin is primarily attributed to its interaction with biological macromolecules, enabling it to inhibit enzymes and interfere with cellular processes. This compound is known for its ability to act as an anticoagulant by inhibiting vitamin K-dependent synthesis of clotting factors, similar to warfarin. 3-Hydroxycoumarin has various applications, particularly in the field of medicinal chemistry, where it is explored for its potential therapeutic effects. It serves as a pivotal scaffold in the development of anticoagulant drugs and has been investigated for its antioxidant, antimicrobial, and anticancer properties. Its diverse biological activities make it a subject of ongoing research, with potential applications extending to drug development and biochemical studies.

Esculetin dibenzyl ether is a chemical compound, which is a derivative of esculetin, a natural coumarin obtained chiefly from plant sources such as the bark of horse chestnut and other similar species. The source of esculetin dibenzyl ether is typically synthesized from natural precursors through chemical modifications, allowing for the exploration of its structural analogs. The mode of action of esculetin dibenzyl ether involves interactions at the molecular level with various biological pathways. Its structural attributes allow for the potential modulation of enzyme activity, antioxidant properties, and interactions with cellular signaling mechanisms, which are areas of considerable interest in scientific research. This compound finds uses primarily in research applications, serving as a tool for investigating the biological activities and therapeutic potential of coumarin derivatives. Specifically, it is used in the study of anti-inflammatory, antioxidant, and potential anticancer properties, making it valuable in drug discovery and development contexts. Its application is crucial in elucidating the mechanistic pathways of natural compounds and their synthetic analogs in biological systems.

Lactone

Seselin is a natural product from Plumbago zeylanica. Seselin shows anti-inflammatory and antiviral activity.

3-Acetyl-5-hydroxymethyl-7-hydroxycoumarin is a synthetic coumarin derivative, which is a class of organic compounds often found in natural products. These compounds are derived from plant sources and are known for their significant biochemical effects and aromatic properties. The mode of action of 3-Acetyl-5-hydroxymethyl-7-hydroxycoumarin involves interactions at the molecular level, where it can exhibit various biological activities, such as antioxidant and antimicrobial effects. Due to the hydroxyl and acetyl functional groups present, it can participate in redox reactions and binding interactions, affecting biochemical pathways. In scientific research, this compound is explored for its potential applications in pharmacology and biochemistry. The compound's ability to modulate oxidative stress and microbial growth makes it valuable for studying disease models and developing therapeutic agents. Additionally, its structural properties allow for further chemical modifications, facilitating the synthesis of derivatives with enhanced or targeted activities.

Lactone

Murralongin is a natural compound that falls under the category of sesquiterpenes, a class of terpenoids characterized by their three isoprene units. It is derived from the leaves and stems of the plant Eremophila mitchellii, a species known for its rich diversity of bioactive compounds often utilized in traditional medicine. The primary mode of action of Murralongin involves modulation of specific enzymatic pathways, potentially influencing a range of biological processes, including anti-inflammatory and antimicrobial activities. Recent studies have focused on its potential therapeutic uses, exploring its efficacy as an anti-cancer agent by targeting cellular pathways involved in cancer cell proliferation and survival. Additionally, Murralongin's ability to inhibit certain microbial growth suggests applications in developing new antimicrobial drugs, addressing issues related to resistant bacterial strains. Furthermore, its anti-inflammatory properties imply potential applications in managing chronic inflammatory conditions, where current treatments may have significant limitations or side effects. Overall, Murralongin represents a promising subject for further research with the potential to contribute significantly to the development of new therapeutic agents.

Coumestrol analytical standard provided with w/w absolute assay, to be used for quantitative titration.

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Skimmin is a bioactive compound, classified as a coumarin, which is derived from various plant sources, particularly the bark of certain tree species. It functions through the modulation of enzyme activity, including antioxidant and anti-inflammatory pathways, by interacting with specific cellular receptors and enzymes. The primary use of Skimmin in scientific research is to explore its potential therapeutic effects, particularly in areas such as oncology, cardiovascular health, and metabolic diseases. Its ability to modulate physiological processes at the cellular level allows scientists to investigate its efficacy in inhibiting tumor growth, reducing oxidative stress, and lowering inflammation. Additionally, it serves as a crucial tool for elucidating biochemical pathways associated with human diseases. The compound's diverse biological activities make it an important molecule for pharmacological studies, with ongoing research aimed at understanding its full range of mechanisms and potential therapeutic applications. Scientists focus on optimizing its efficacy and bioavailability, seeking to unlock new avenues for medicinal chemistry and drug development.

Oroselol is an innovative beta-adrenergic blocker, which is a synthetic derivative with unique cardiovascular targeting properties. It is sourced from engineered chemical synthesis, utilizing advanced molecular design to enhance selectivity for beta-adrenergic receptors. The mode of action of Oroselol involves competitive antagonism of beta-1 and beta-2 adrenergic receptors, leading to a decrease in heart rate and myocardial contractility. This blockade of adrenergic stimulation results in reduced cardiac output and lower blood pressure. The primary uses of Oroselol lie in its potential applications for managing cardiovascular conditions such as hypertension, angina pectoris, and arrhythmias. Its precise receptor selectivity may offer a therapeutic advantage over traditional beta-blockers by minimizing side effects associated with non-targeted action. Oroselol's pharmacokinetics and dynamic properties are being closely studied to understand its efficacy and safety profile in clinical settings. This compound's novel aspects make it a subject of considerable interest in pharmacological research, where its impact on cardiovascular therapy continues to be evaluated.

Trans-Khellactone is a naturally occurring lactone derivative, which is isolated from plants of the Apiaceae family. This compound exhibits a variety of biological functions due to its unique chemical structure, which includes a dihydropyran ring. Trans-Khellactone's mode of action involves interacting with various cellular pathways, potentially modulating enzyme activity, receptor binding, and influencing signal transduction processes. Due to its diverse range of activities, trans-Khellactone is of significant interest in the field of medicinal chemistry. It has been studied for its potential therapeutic applications, including anti-inflammatory, anti-cancer, and anti-microbial effects. Research into trans-Khellactone's mechanisms and efficacy continues to expand its possible applications in drug development and other areas of biomedical research.

Lactone

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(+)-Peucedanol is a sesquiterpene compound, which is a type of natural organic compound composed of three isoprene units resulting in a 15-carbon backbone. It is derived from various species within the plant genus Peucedanum, known for their rich content of bioactive compounds. The stereoisomerism indicated by the "(+)" suggests a specific three-dimensional configuration that may influence its biological activity. The mode of action of (+)-Peucedanol is not completely elucidated but is thought to involve interactions with cellular components leading to modulation of pathways associated with anti-inflammatory and possibly antioxidant effects. By interacting at the molecular level, it may influence the biological processes that govern inflammation and oxidative stress. (+)-Peucedanol finds application in scientific research, primarily in the study of its pharmacological properties. Researchers focus on its potential therapeutic uses, exploring its efficacy in inflammation-related diseases and its role in cellular protection mechanisms. The compound's effects on cellular signaling pathways and potential as a lead compound for drug development are areas of ongoing investigation.

Daphnetin-7-methylether analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Arnottinin is a bioactive compound, which is derived from natural plant sources. It functions primarily through modulation of specific cellular pathways, targeting key receptors that regulate physiological responses. This compound exhibits its mode of action by influencing signal transduction pathways, effectively altering cellular activities at the molecular level. Arnottinin is known for its applications in various biomedical research settings. It is commonly utilized in the study of disease pathogenesis, particularly in examining inflammatory mechanisms and cellular growth processes. Researchers employ it to explore therapeutic potentials in oncology and neurodegenerative diseases, owing to its ability to interact with cellular targets. Additionally, Arnottinin serves as a pivotal tool in drug discovery, facilitating the development of more targeted and efficient therapeutic agents.

Natural glycoside

Dihydroseselin (8,8-dimethyl-9,10-dihydropyrano[2,3-h]chromen-2-one) is a coumarin derived from the roots of Toddalia.

Byakangelicol may reduce P-gp at BBB and has anti-inflammatory effects by hindering COX-2 and PGE2 in A549 cells.

Alloisoimperatorin is a naturally occurring furanocoumarin compound, which is extracted from certain plant species, primarily those belonging to the Apiaceae family. As a type of coumarin derivative, it is synthesized through intricate plant metabolic pathways involving the precursors umbelliferone and isopentenyl pyrophosphate, among others. The mode of action of alloisoimperatorin is not completely elucidated, but it is believed to exert biological effects through modulation of enzymatic activities and interference with cellular signaling pathways. Its interaction with cytochrome P450 enzymes and perturbation of calcium ion channels might contribute to its diverse biological activities. Alloisoimperatorin is of considerable interest for its potential pharmacological applications, particularly in the fields of anti-inflammatory and anti-cancer research. It has been explored for its inhibitory effects on tumor cell proliferation and its capability to induce apoptosis in vitro. Additionally, due to its structural properties, it may serve as a precursor or inspiration for the development of novel therapeutic agents. Further research is necessary to fully understand its mechanisms and to evaluate its efficacy and safety in clinical contexts.

8-Geranyloxypsoralen is a natural furanocoumarin, which is a secondary metabolite typically derived from plants, particularly those in the Rutaceae family. Its source lies predominantly in certain fruits and herbs, where it functions as a natural defense compound. The mode of action of 8-Geranyloxypsoralen involves its interaction with DNA upon activation by ultraviolet (UV) light. It can form covalent bonds with pyrimidine bases, primarily thymine, in the DNA strands. This interaction leads to the formation of monoadducts, which can subsequently result in crosslinking upon further exposure to UV-A, disrupting DNA replication and transcription processes. 8-Geranyloxypsoralen finds its applications in phototherapy and is often studied for its potential therapeutic uses in skin diseases, such as psoriasis, and vitiligo. Its ability to modulate biological responses under light exposure makes it a candidate for further exploration in understanding light-mediated cellular processes. Furthermore, it provides insights into plant defense mechanisms and the complex interactions between plant-derived compounds and biological systems under environmental stressors.

Lactone

Isoimperatorin is a naturally occurring furanocoumarin, which is a phytochemical compound found in certain plants, particularly within the Apiaceae family, such as Angelica dahurica. It is extracted from these botanical sources through processes like solvent extraction. Isoimperatorin exhibits a diverse mode of action, including the inhibition of various enzymes and modulation of signaling pathways. It has demonstrated significant effects on cytochrome P450 enzymes, potentially influencing drug metabolism. Additionally, Isoimperatorin has shown antioxidant properties and the ability to interfere with cell proliferation and apoptosis mechanisms. Isoimperatorin is extensively studied for its potential therapeutic applications. Research indicates promising uses in pharmacology, particularly in areas involving anti-inflammatory, anticancer, and antimicrobial effects. Its ability to interact with enzymatic processes suggests potential roles in drug development and metabolic studies. Additionally, Isoimperatorin is of interest in the field of agriculture as a natural pesticide due to its bioactivity against certain pests. Ongoing research continues to explore its full spectrum of biological activities and possible applications in both medical and industrial domains.

Coumarin 6 (Coumarin VI) is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.

7,8-Dimethoxycoumarin is a natural product isolated from Artemisia caruifolia and Wikstroemia indica.

7-Methoxycoumarin-3-carboxylic acid is used for HPLC derivatization. It is also used to develop FRET probes for analyzing protease activities.

Oxypeucedanin hydrate acetate is a furanocoumarin, primarily classified as a phytochemical. It is derived from various plant sources, particularly from species in the Apiaceae family, such as Peucedanum and Angelica. These compounds are typically isolated through advanced extraction and chromatographic techniques. The mode of action of oxypeucedanin hydrate acetate involves the inhibition of cytochrome P450 enzymes, which play a pivotal role in the metabolism of drugs within the liver. This compound can influence the pharmacokinetics of co-administered pharmaceuticals and is thereby of significant interest to pharmacologists and toxicologists. In research, oxypeucedanin hydrate acetate has been investigated for its potential applications in cancer therapy, owing to its ability to induce apoptosis in certain cancer cell lines. Additionally, it is studied for its antimicrobial properties and its role in modulating cellular oxidative stress responses. These attributes make it a valuable subject in the exploration of new therapeutic agents and in understanding herb-drug interactions within complex biological systems.

8-Hydroxybergapten may have anti-wrinkle activity.

Lactone

Lactone

Coumestrol dimethylether analytical standard provided with w/w absolute assay, to be used for quantitative titration.

M04141 - 4-Methylumbelliferyl beta-D-xylopyranoside