Coumarins

Fraxin is a naturally occurring anticoagulant, which is derived from the bark of certain species of the Fraxinus tree. It functions by inhibiting thrombin and other key enzymes in the coagulation cascade, thus preventing the formation of blood clots. This mode of action makes it particularly valuable in research settings focused on cardiovascular diseases, as well as in the development of therapeutic agents targeting coagulopathies. Applications of Fraxin extend to experimental investigations involving blood coagulation mechanisms and the testing of novel anticoagulant therapies. It is also utilized within pharmacological studies to assess hemostatic balance and the potential for thrombosis under various pathological conditions. For scientists delving into biochemistry, hematology, or pharmacology, Fraxin offers a unique opportunity to explore the complex interactions within the blood coagulation system.

Lactone

Lactone

Lactone

Imperatorin is a furanocoumarin compound, which is a natural product primarily isolated from plants in the Apiaceae family, such as Angelica dahurica and Citrus species. This compound is characterized by its unique chemical structure that includes a furan ring fused to a coumarin backbone. Imperatorin exerts its biological activities through multiple modes of action, including the modulation of enzymatic activity, interference with cellular signaling pathways, and binding to specific biological targets. The compound is involved in various pharmacological applications due to its anti-inflammatory, antimicrobial, and anticancer properties. It has been studied for its potential in improving cardiovascular health by regulating blood pressure and reducing thrombosis. Moreover, imperatorin has shown promise in neuromodulatory applications, offering potential benefits for neuroprotective interventions. Researchers continue to explore its diverse bioactivities, focusing on its potential in medicinal and therapeutic contexts. Understanding its mechanisms can advance the development of new strategies in drug design and discovery, reinforcing its significance in scientific research and pharmacology.

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M04110 - gamma-L-Glutamic acid 7-amido-4-methylcoumarin

Isobergapten analytical standard provided with w/w absolute assay, to be used for quantitative titration.

5,7-Dihydroxy-4-methylcoumarin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Calycanthoside (Isofraxidin 7-O-beta-D-Glucoside) is a natural compound isolated from Angelica tenuissima.

Lactone

Lactone

Fraxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Salvianolic acid A has antioxidant, hepatoprotective, antithrombotic effect, and antiplatelet actions. it also has a significant protective effect against isoproterenol-induced myocardial infarction; it activates the Nrf2/HO-1 axis in RPE cells and protects against oxidative stress via activation of Akt/mTORC1 signaling. Salvianolic acid A (oral) can significantly improve glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats. It is a novel matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats.

Osthol analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Daphnetin-8-glucoside is a natural phenolic glucoside compound derived from plants of the Thymelaeaceae family, specifically from the Daphne genus. This compound is produced by the glycosylation of daphnetin, a coumarin derivative found in various botanical sources. The glycoside linkage enhances its solubility and stability, facilitating its bioavailability. Daphnetin-8-glucoside exhibits potent antioxidant and anti-inflammatory activities, mediated through the scavenging of free radicals and inhibition of pro-inflammatory cytokine production. Additionally, it modulates signal transduction pathways involved in cellular oxidative stress responses. In scientific research, Daphnetin-8-glucoside is used for its potential therapeutic effects in managing oxidative stress-related disorders and inflammatory conditions. Its biological activities make it a candidate for investigating new therapeutic avenues in neurodegenerative diseases, cardiovascular health, and skin protection. Researchers explore its efficacy and mechanism of action to understand its role in cellular protection and its potential integration into clinical applications. The study of such natural compounds contributes to the broader understanding of plant-derived bioactives and their impact on human health.