Coumarins

Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS

4-Hydroxy-3-phenylcoumarin is an organic compound, which is a derivative of coumarin. It is synthetically derived through chemical modification processes that introduce a hydroxy group and a phenyl ring to the coumarin core structure. Its mechanism of action involves the inhibition of vitamin K epoxide reductase, an enzyme critical for the cyclic conversion of vitamin K. This inhibition prevents the activation of vitamin K-dependent clotting factors, thereby exerting its anticoagulant effects. In practice, 4-Hydroxy-3-phenylcoumarin and its analogs are primarily used as anticoagulants in medical settings to prevent thrombosis and embolism in patients at risk for stroke, myocardial infarction, or atrial fibrillation. Additionally, they have been employed in research settings to study coagulation pathways and the role of vitamin K in various physiological processes. Researchers continue to investigate analogs of 4-Hydroxy-3-phenylcoumarin for enhanced specificity and reduced side effects in clinical applications.

Applications A labelled metabolite of Coumarin. The aglucon of skimmin. Present in many plants. References Schilling, et al.: Nature, 221, 664 (1969), Indahl, S., et al.: Xenobiotica, 1, 13 (1971), Thompson, S.G., et al.: Antimicrob. Agents Chemother., 18, 264 (1980),

8-Hydroxy-7-methoxycoumarin is a fluorescent compound, which is a derivative of the coumarin family. This compound is typically sourced through synthetic organic chemistry processes involving the modification of natural coumarin compounds. Its mode of action involves the ability to absorb ultraviolet light and re-emit it as visible light, a characteristic feature of fluorescent molecules. This property makes it particularly useful in scientific research. In biochemical applications, 8-Hydroxy-7-methoxycoumarin is widely used as a fluorescent probe, aiding in the study of enzyme activities, protein interactions, and cellular imaging. Because it can provide a distinct fluorescent signal, it is invaluable for tracking molecular and cellular processes, enabling scientists to visualize and quantify various biological interactions and changes. The utility of this compound extends to areas such as environmental monitoring, medical diagnostics, and the development of new materials, where its fluorescent properties can be leveraged to detect the presence of specific molecules or changes in chemical environments. Its robustness in diverse conditions makes it a versatile tool in the arsenal of chemical and biological researchers.

Bergamottin is a furanocoumarin compound, which is primarily found in grapefruit juice and other citrus fruits. It is derived from natural sources, specifically within the fruit and peel of grapefruits. The mode of action of Bergamottin involves the inhibition of the cytochrome P450 enzymes, particularly CYP3A4, which play a significant role in the metabolism of various drugs. This inhibitory effect can alter the pharmacokinetics of certain medications by increasing their bioavailability. Bergamottin is extensively studied for its applications in pharmacokinetics and drug interactions. Its presence can lead to significant clinical implications when patients consume grapefruit juice while on medication metabolized by CYP3A4. This interaction can enhance the therapeutic or adverse effects of drugs, requiring careful monitoring and potential dosage adjustments. Researchers explore Bergamottin’s role to better understand drug metabolism and to refine therapeutic strategies, ensuring safe and effective drug delivery. Understanding these interactions is crucial in the development of new pharmaceuticals and in clinical practice to prevent adverse outcomes associated with drug interactions.

Vinaxanthone (SM-345431), an extract from Penicillium chrysogenum, is a semaphorin3A inhibitor with antimicrobial activity.

Byakangelicol methanolate is a bioactive compound, which is a derivative of furanocoumarins, typically found in various plant species. It is naturally sourced from Angelica plants, known for their rich profile of therapeutic compounds. The mode of action of Byakangelicol methanolate involves the inhibition of specific enzymes related to inflammatory pathways, potentially modulating immune responses and reducing inflammation. This compound is of significant interest due to its potential applications in developing treatments for inflammatory-related conditions and possibly other therapeutic areas. Research into Byakangelicol methanolate focuses on understanding its pharmacological properties and exploring its benefits within pharmaceuticals for treating a range of inflammatory disorders. Its ability to act on specific biological pathways might provide insights into new therapeutic mechanisms, making it a subject of interest for scientists investigating novel anti-inflammatory agents.

2-(7-Methoxy-2-oxo-2H-chromen-4-yl)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T64951 and the CAS number is 62935-72-2.

7-Methylcoumarin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.