Organometallic Ligands

Farnesyltransferase inhibitor

Urolithin M6 is a metabolite, which is a bioactive compound derived from the metabolism of ellagitannins and ellagic acid found in certain dietary polyphenols. These polyphenols are abundant in fruits such as pomegranates, berries, and nuts. The transformation into urolithins, including Urolithin M6, is facilitated by the gut microbiota, which metabolizes these ellagitannins in the gastrointestinal tract. Urolithin M6 exerts its effects through modulation of cellular and molecular pathways, particularly those involved in mitochondrial health and autophagy. By acting on these pathways, Urolithin M6 enhances mitochondrial function and promotes cellular recycling processes, which may contribute to improved cellular health and longevity. The applications of Urolithin M6 span across various domains of human health, given its potential role in combating aging, enhancing mitochondrial function, and possibly affecting muscle endurance. Current scientific research is exploring its efficacy and mechanism in more depth, potentially opening new avenues for therapeutic interventions targeting age-related decline and metabolic disorders. Scientists are investigating its implications on human health, with an emphasis on its bioavailability and bioactivity in clinical settings.

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

PI3K/mTOR kinase inhibitor; anti-neoplastic

TNO155 is an innovative therapeutic agent, commonly classified as a small-molecule inhibitor, which is derived from rational drug design based on precision oncology principles. Its mode of action involves selective inhibition of a specific protein tyrosine phosphatase, which plays a critical role in cellular signaling pathways that are often dysregulated in cancer. This inhibition effectively disrupts aberrant signaling, thereby suppressing tumor cell proliferation and inducing apoptosis in malignant cells. The primary applications of TNO155 are in the field of oncology, particularly for targeting tumors characterized by mutations that lead to unregulated signal transduction pathways. It holds potential for use in combination therapies, where it can enhance the efficacy of other chemotherapeutic agents by sensitizing cancer cells to treatment, or as a monotherapy in stratified patient populations defined by specific genetic biomarkers. Current research and clinical trials are exploring its efficacy across a range of solid tumors to fully delineate its therapeutic profile and utility in personalized medicine approaches.

LF 11 is a probiotic that contains live bacteria, which are intended to promote healthy intestinal flora. The bacteria in LF 11 have been shown to inhibit the growth of other bacteria by releasing antimicrobial peptides. These peptides are amphipathic, meaning they can be soluble in both water and oil phases, and they have been shown to have an interactive effect on bacterial vaginosis-causing strains. LF 11 also has antiinflammatory activity, which may be due to its ability to increase insulin-stimulated glucose uptake and reduce fatty acid biosynthesis in adipocytes.

ML150 is a chemical compound, which is a synthetic molecule developed through advanced organic synthesis. The product operates as an allosteric inhibitor of a specific enzyme, modulating its activity through non-competitive binding. This mechanism allows for a highly selective interaction with the enzyme, altering its conformation and thereby influencing its function in a controlled manner. ML150 is utilized primarily in biochemical research to investigate the regulatory mechanisms of enzyme pathways. Its ability to specifically target and modulate enzyme activity makes it a valuable tool for elucidating pathway dynamics and potential drug targets. Additionally, ML150 can be used in experiments designed to understand enzyme-related dysfunctions in various diseases, offering insights into novel therapeutic approaches. This compound is integral to studies aiming to dissect complex biological interactions at the molecular level.

06:0-06:0 NBD pg is a synthetic fluorescence probe which is used in the field of biochemistry and cell biology. This product is derived from phosphatidylglycerol and carries a nitrobenzoxadiazole (NBD) fluorescent group attached through an acyl chain. The mode of action involves the incorporation of the NBD-labeled lipid into biological membranes or liposomes, enabling visualization and analysis of lipid behavior and protein-membrane interactions under a fluorescence microscope or via spectroscopic methods. This compound is highly valued for its applications in studying cellular membrane dynamics, elucidating lipid metabolism, and examining the mechanisms of lipid-protein interactions. Researchers utilize 06:0-06:0 NBD pg in experiments to trace lipid distribution and movement within membranes, providing insights into biological processes such as endocytosis, membrane fusion, and vesicular trafficking. Through its unique fluorescence properties, it serves as a versatile tool for advancing our understanding of the complex interplay of lipids and proteins in cellular environments.

Benzyl 3-fluoro-4-(3-oxopyrrolidin-1-yl)phenylcarbamate is a synthetic carbamate derivative, which is derived from the combination of fluorinated aromatic structures and pyrrolidinone rings. The compound is designed to act on biological systems by leveraging the unique properties of its fluorine and carbamate constituents. Fluorine's electronegativity can alter the compound's pharmacokinetics, while the carbamate moiety offers potential reactivity with enzymatic or cellular targets. The mode of action primarily involves interactions at the molecular level that may influence receptor binding, enzyme activity, or other biochemical pathways. The structural components of Benzyl 3-fluoro-4-(3-oxopyrrolidin-1-yl)phenylcarbamate suggest a role in modulating certain protein functions or pathways, although precise mechanisms would depend on further empirical validation. Potential applications of this compound could span various fields of pharmacology, particularly in exploring novel therapeutic agents. Its structural specificity allows for targeted research into neurological or metabolic pathways, potentially offering routes for the development of new drugs with improved efficacy or safety profiles. Scientists are particularly interested in exploring its ability to intervene in complex biological systems with high selectivity.

Copper-binding growth factor

A-1165442 is a selective EP2 receptor antagonist, which is a class of compound utilized in pharmacological research. This product is synthesized through chemical processes aiming to block specific biological pathways. The mode of action for A-1165442 involves the inhibition of the EP2 receptor, a subtype of the prostaglandin E2 (PGE2) receptor family. By selectively binding to this receptor, A-1165442 effectively blocks the downstream signaling pathways activated by PGE2 binding, providing a sophisticated method to study and manipulate these pathways. This compound is primarily used in scientific studies to investigate the role of EP2 receptors in various physiological and pathological processes. Applications include research into inflammatory responses, pain perception, and diseases such as cancer and neurodegeneration. By using A-1165442, researchers can better understand the involvement of EP2 receptors in these processes, potentially aiding in the development of new therapeutic strategies.

Acat-in-1 cis isomer is an enzymatic inhibitor, which is synthesized through organic chemical processes. It is particularly known for its action as an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT), an enzyme crucial for the esterification of cholesterol. This inhibition occurs through the specific binding to the active site of ACAT, preventing the conversion of cholesterol to cholesteryl esters, and thereby influencing the cholesterol metabolism pathways. The uses and applications of Acat-in-1 cis isomer are primarily in the research domain, particularly in studies involving lipid metabolism, atherosclerosis, and cholesterol-related diseases. It serves as a valuable tool for scientists investigating the biochemical and physiological roles of cholesterol and its derivatives in various biological systems. By elucidating the mechanisms of cholesterol homeostasis, researchers can better understand the pathogenesis of cardiovascular diseases and potentially develop targeted therapeutic strategies.

HO-3867 is a synthetic small molecule, which is a derivative of curcumin, designed to enhance its therapeutic potential. Curcumin, a natural compound found in turmeric, is known for its anti-inflammatory and anticancer properties; however, its application is limited due to poor bioavailability and rapid systemic elimination. HO-3867 is engineered to overcome these limitations with structural modifications, improving its stability and bioavailability. HO-3867 functions by selectively targeting cancer cells, inducing apoptosis while sparing normal, healthy cells. It acts through the modulation of various signaling pathways, such as the activation of pro-apoptotic factors and inhibition of NF-κB, a protein complex involved in cellular responses to stress, cytokines, free radicals, and other factors. This selectivity is key to reducing potential side effects commonly associated with traditional chemotherapy agents. In terms of applications, HO-3867 shows promise in preclinical studies as an anticancer agent, especially for treating ovarian cancer and glioblastoma. Its dual ability to inhibit cancer cell proliferation while sparing normal cells makes it an attractive candidate for further research and development in oncological therapeutics. Continued investigation into its pharmacokinetics and efficacy in clinical settings remains crucial.

JHU-083 is an investigational therapeutic agent, which is a potent small molecule inhibitor of glutamine metabolism. It originates from academic institutions focused on advancing biomedical research. The mode of action of JHU-083 involves the inhibition of glutaminase, an enzyme critical for converting glutamine to glutamate, a key energy source for proliferating cells. By impeding this metabolic pathway, JHU-083 effectively starves cancer cells of the necessary components for growth and survival. In scientific research, JHU-083 is utilized primarily to study the modulation of tumor immune microenvironments and the reprogramming of immune cell metabolism. Its applications extend into cancer immunotherapy, where it facilitates the investigation of new therapeutic approaches combining metabolic inhibition with immune modulation strategies. Additionally, JHU-083 serves as a promising tool for exploring the metabolic dependencies of various malignancies, contributing to the broader understanding of tumor biology and paving the way for novel interventions.

Carbimazole is an imidazole antithyroid agent that is used to treat hyperthyroidism. It reduces the production of diiodotyrosine and thyroxine, as well as the uptake and concentration of inorganic iodine by the thyroid. Once it has been converted to methimazole, the thyroid peroxidase enzyme is inhibited from coupling and iodinating the tyrosine residues on thyroglobulin therefore lowering the production of the thyroid hormones T3 and T4. Carbimazole is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

WAY 127093B racemate is a small organic compound, which is a synthesized chemical product with selective inhibitory properties. It is designed to target the cyclooxygenase-2 (COX-2) enzyme, which is primarily sourced through organic synthesis in laboratory settings, rather than being naturally derived. The mechanism of action involves specific blockade of the COX-2 enzyme, which plays a crucial role in catalyzing the conversion of arachidonic acid to prostaglandins. These prostaglandins are mediators of inflammation, pain, and fever. By inhibiting COX-2, WAY 127093B racemate effectively reduces the production of pro-inflammatory prostaglandins while sparing cyclooxygenase-1 (COX-1) pathways, which are important for gastric and renal function. The primary uses and applications of WAY 127093B racemate center around its potential as an anti-inflammatory agent. It offers a targeted approach for exploring new treatments in conditions characterized by inflammation, such as arthritis. Additionally, due to its selectivity, it provides a valuable tool in research settings for dissecting the roles of COX-2 versus COX-1 in physiological processes and could guide the development of new therapeutic strategies in inflammatory diseases.

ETP-46464 is a small molecule kinase inhibitor, which is synthesized through a complex organic chemistry process. It functions by selectively targeting and inhibiting specific kinase enzymes, thereby disrupting key signaling pathways involved in cell proliferation, survival, and differentiation. The primary application of ETP-46464 lies in its potential use as a research tool for studying cellular signaling and exploring kinase-related pathways. This compound is particularly significant in cancer research, where dysregulated kinase activity often drives oncogenesis. By inhibiting these kinases, ETP-46464 provides insights into their biological roles and potential as therapeutic targets. Additionally, it has applications in the development of novel cancer therapies, where its efficacy can be assessed in preclinical models to understand its effects on tumor growth and progression.

2-(2-Acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methylvaleramide is a synthetic compound that functions as an antifungal agent. It is derived from chemical synthesis, allowing precise modifications for enhanced efficacy. This compound acts by inhibiting vital fungal cell processes, disrupting cell wall synthesis, and impeding protein production, ultimately causing cell death. The primary applications of this compound are in biomedical research and pharmaceutical development, where it is utilized to study fungal pathogenesis and to develop therapeutic agents against fungal infections. Its capability to interact with specific fungal enzymes makes it a valuable tool in unraveling biochemical pathways and identifying potential targets for antifungal drugs. The specificity and potency of 2-(2-Acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methylvaleramide highlight its importance in advancing our understanding and treatment of fungal diseases.

Perakine is an indole alkaloid, which is a naturally occurring compound obtained primarily from the plant Rauvolfia species. As an indole alkaloid, it is synthesized through complex biosynthetic pathways within the plant, involving the secondary metabolism that characterizes many biochemical systems in flora. The mode of action of Perakine is primarily associated with its ability to interfere with certain cellular processes, which leads to its potential antitumor and cytotoxic effects. It targets specific cellular pathways, disrupting the proliferation of malignant cells, making it a subject of interest in oncology research. In terms of applications, Perakine is being studied for its potential use in developing novel antitumor therapies. Its unique properties as a plant-derived compound offer advantages in the exploration of natural product-based chemotherapeutic agents. Research is ongoing to further elucidate its mechanisms and optimize its efficacy in clinical settings, highlighting its significance in expanding the landscape of cancer treatment options.

Inhibits MET, VEGFR2, Ron, AXL, Tie-2, Flt-1, Flt-3 and Flt-4 tyrosine kinases