Organometallic Ligands

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Dual inhibitor of thromboxane receptor and DP2 postanoid receptor

Scrambled 10Panx trifluoroacetate is a synthetic peptide, which is a stabilized form of the amyloid-beta precursor protein. It is derived through solid-phase peptide synthesis and incorporates a trifluoroacetate counterion to enhance stability and solubility. The mode of action involves interaction with specific protein receptors and cellular pathways to mimic amyloid-beta aggregation in vitro, providing a reliable model for physiological processes. This peptide is primarily utilized in research settings focused on neurodegenerative diseases, particularly those related to amyloid plaque formation such as Alzheimer's disease. Its applications extend to studying protein aggregation, testing potential therapeutic inhibitors, and elucidating molecular mechanisms underlying disease progression. By offering a consistent and reproducible system, Scrambled 10Panx trifluoroacetate facilitates the exploration of treatments and interventions targeting amyloid-related pathologies.

Sn(IV) mesoporphyrin IX dichloride is a synthetic porphyrin derivative, which is a metalloporphyrin complex formed by the incorporation of tin into the porphyrin structure. This compound originates from the modification of mesoporphyrin IX, a naturally occurring tetrapyrrole, and is further functionalized with chloride ligands. The mode of action of Sn(IV) mesoporphyrin IX dichloride primarily involves the inhibition of heme oxygenase, an enzyme responsible for the catabolism of heme into biliverdin, carbon monoxide, and free iron. This inhibition results in the modulation of heme metabolism, which can have broad implications in various physiological and pathological processes. The compound has been extensively studied for its potential therapeutic applications, particularly in conditions where the modulation of heme oxygenase activity is beneficial. Such conditions include neonatal jaundice, where it may help in reducing bilirubin levels, and certain cancers, where it could help in modulating tumor microenvironments. Additionally, due to its ability to impact oxidative stress and inflammatory responses, Sn(IV) mesoporphyrin IX dichloride might find applications in diseases marked by these pathways.

Astemizole is an antihistamine drug used to treat allergy symptoms. This drug is a histamine-1 receptor antagonist and does not cross the blood-brain barrier. Its binding to histamine receptors suppresses flare ups and pruritus. Astemizole is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

7-Chloro-3,4-dihydro-2-(3-pyridyl)-1(2H)-naphthalenone is a prenylated aromatic amine that is metabolized to 1,4-benzodioxane by cytochrome P450 enzymes. The enzyme activities of 7-chloro-3,4-dihydro-2-(3-pyridyl)-1(2H)-naphthalenone have been shown to be dose dependent in rat liver microsomes and in testicular incubations. This compound is not reactive with the electron spin resonance spectrometer (ESR) at room temperature but becomes highly reactive when it is warmed up. This increased reactivity may be due to an increase in the concentration of free radicals or an increase in the number of accessible sites on the molecule after warming.

Potential treatment for gout and rheumatoid arthritis

Positive allosteric modulator of GABA(A) receptor

Inhibitor of SHIP2 phosphatase

Namitecan is a semi-synthetic camptothecin derivative, derived primarily from the bark of the Camptotheca acuminata tree, a source known for potent antitumor properties. Its mode of action involves the inhibition of DNA topoisomerase I, an enzyme critical for DNA replication. By stabilizing the covalent bond between DNA and topoisomerase I during the replication process, Namitecan effectively induces DNA damage, resulting in apoptosis of rapidly dividing tumor cells. This compound is of significant interest in oncology research, particularly for its potential application in the treatment of various cancers, including solid tumors and hematological malignancies. Studies have shown its efficacy in disrupting tumor growth, leading to its exploration in combination therapies to enhance antitumor effects and overcome resistance seen in conventional treatments. Namitecan's pharmacokinetics and favorable lipophilicity also facilitate its cellular uptake, rendering it a promising candidate for further investigation in preclinical and clinical settings.

Agonist of hypothalamic decapeptide GnRH; increases LH and FSH release

T-448 is a synthetic compound that functions as a biochemical agent, specifically engineered through advanced organic synthesis methods. Its composition emerges from the deliberate manipulation of chemical properties to achieve desired functional characteristics. T-448 operates by selectively interacting with specific biochemical pathways, enabling it to modulate enzymatic reactions or receptor activities with precision. This compound is primarily used in research and development settings, where it serves as a tool for probing biological mechanisms or for the development of other therapeutic agents. Scientists utilize T-448 to investigate cellular processes, test hypotheses in experimental pharmacology, or elucidate underlying mechanisms in molecular biology. Its precision in targeting makes it particularly valuable for studies requiring detailed control over biochemical interactions.

CD 2314 is an innovative compound used as a neuromodulatory agent, derived from advanced synthetic pathways. This compound acts selectively on specific neural receptors through ligand-receptor interactions, making it a valuable tool for elucidating complex neurological pathways. By modulating synaptic transmission and influencing neurotransmitter release, CD 2314 offers potential insights into the synaptic mechanisms underpinning cognitive processes. In scientific research, CD 2314 is utilized to explore the molecular dynamics involved in neurodegenerative diseases and synaptic plasticity. Its precise receptor modulation properties make it an indispensable resource in experimental neuroscience, particularly in studies focusing on receptor-specific pathways and therapeutic target validation. Through controlled application in in vitro and in vivo models, CD 2314 aids in expanding our understanding of neural networks and cognitive function.

Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-5-carboxylate is a synthetic small molecule inhibitor that has been extensively studied for its role in oncology. The compound is synthesized through a multistep chemical process involving advanced organic synthesis techniques, resulting in a highly specific chemical entity. Its mode of action primarily involves the inhibition of key enzymatic pathways that are critical in cell proliferation and survival, specifically targeting pathways associated with cancer growth and metastasis. Due to its specificity and effectiveness in disrupting cancer cell signaling, this compound is primarily utilized in preclinical studies to explore its potential as an anticancer agent. Its applications extend to investigating the inhibition of various cancer-related proteins and providing insights into tumor resistance mechanisms. Research with this molecule aids in the development of targeted cancer therapies, offering hope for improved treatment efficacy with reduced side effects compared to conventional chemotherapy.

Fluorosalan is a topical antiseptic, which is a fluorinated salicylamide derivative with bacteriostatic properties. This product is synthesized through the halogenation of salicylamide, a compound known for its antimicrobial effects. The incorporation of fluorine enhances the chemical stability and increases its effectiveness against a broad spectrum of pathogenic microorganisms. The mode of action of Fluorosalan involves the disruption of microbial cell membranes and inhibition of essential enzyme systems within the pathogen, thus preventing their replication and survival. Its efficacy is attributed to its ability to interfere with microbial metabolism and cellular integrity effectively. Fluorosalan is predominantly employed in clinical settings for the treatment of superficial skin infections and as a preventive measure in surgical procedures to reduce infection rates. The application is typically through topical formulations, enabling direct delivery to the site of infection and minimizing systemic side effects. Due to its potent antibacterial properties and low incidence of resistance, Fluorosalan remains a critical component in infection control protocols.

Inhibits CK1 α, δ and ε isoforms (IC50 values = 8.9, 0.5, and 4.7 μM, respectively). Induces reprogramming of epiblast-derived stem cells (EpiSCs) to embryonic stem cells (ESCs). If the latter express Oct4-GFP, the compound can be used as a tool to study this signaling pathway.

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17:0-20:4 PI (3,4,5) P3 is a synthetic phosphoinositide, a type of lipid molecule, which is typically derived from chemical synthesis using specialized lipid chemistry techniques. This product is designed to mimic natural phosphoinositides found within the cellular membranes. Its mode of action involves acting as a substrate for studying kinase activities and phosphatase interactions within signaling pathways. 17:0-20:4 PI (3,4,5) P3 plays a critical role in cellular signaling by serving as a docking site for signaling proteins with specific lipid-binding domains, influencing downstream signaling pathways. This product is widely used in research applications to investigate phosphoinositide-mediated signaling pathways, which are vital in numerous cellular processes such as cell growth, survival, and metabolism. It is particularly valuable in examining the roles of PI3K/AKT signaling, as well as in the development of therapeutic strategies targeting these pathways in diseases like cancer and diabetes. The use of 17:0-20:4 PI (3,4,5) P3 provides a controlled and precise framework for scientists to dissect complex cellular mechanisms and understand the nuanced roles of lipid signaling in health and disease.

Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug that is used for the treatment of osteoarthritis. This drug inhibits prostaglandin synthesis via inhibition of COX-2. Lumiracoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Analogue of GABA; GABA receptor agonist used in epilepsy