Opiate Alkaloids

Applications 6α-Oxycodol is a dihydro metabolite of the analgesic opiate Oxycodone (O870600). References Ishida, T. et al.: Drug Metab. Dispos., 7, 162 (1979); Moore, K.A. et al.: J. Anal. Toxicol., 27, 346 (2003); Lalovic, B. et al.: Clin. Pharmacol. Ther., 79, 461 (2006);

Applications A metabolite of Naltrexone. References Portoghese, P., et al,: J. Med. Chem., 37, 579 (1994), Ohkawa, S., et al.: J. Med. Chem., 41, 4177 (1998).

Applications An intermediate of Isomethadone (Isoamidone). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Unterhalt, B., et al.: Pharmaceutica, 68, 229 (2000),

Applications: (R)-Apomorphine-11-sulfate Potassium Salt-d5 is the isotope labelled analog of (R)-Apomorphine-11-sulfate Potassium Salt (A727520); a derivative of (R)-Apomorphine (A727500) which is a dopamine (D1 and D2) receptor agonist, emetic, and antiparkinsonian. References Neumeyer, J.L., et al.: J. Pharm. Sci., 59, 1850 (1970); Ginos, J.Z., et al.: J. Med. Chem., 18, 1194 (1975); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 20, 121 (1991)

Applications The cis-isomer of Mefentanyl; an opiate.Controlled substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Riley, T.N., et al.: J. Pharm. Sci., 62, 983 (1973), Gillespie, T.J., et al.: J. Anal. Toxicol., 6, 139 (1982),

Applications An intermediate in the preparation of Alfentanil and Sufentanil Citrate References Colapret, J., et al.: J. Med. Chem., 32, 968 (1989),

Applications Labelled specific opioid antagonist. Narcotic antagonist. References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993),

Applications Controlled substance (opiate). Analgesic (narcotic). References Ananthan, S., et al.: J. Med. Chem., 47, 1400 (2004), Gimbel, J., et al.: Anesth. Analg., 99, 1472 (2004), Adams, M., et al.: J. Clin. Pharmacol., 45, 337 (2005),

Applications Cyclopropyl Fentanyl Hydrochloride is a controlled substance. Also a derivative compound of Fentanyl (F275005) used as an analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998),

Impurity Fentanyl Impurity D / Fentanyl USP Related Compound E Applications 4-Aminophenyl-1-phenethylpiperidine is a metabolite of 3H-Fentanyl (F274990), which is used as an analgesic.Controlled Substance. References Labroo, R., et al.: Drug Metab., Disposition, 25, 1072 (1997); Zernig, G., et al.: Life Sci., 57, 2113 (1995); Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998);

Applications Oxycodone-D6 is labelled Oxycodone (O870600, HCl salt) which is s a narcotic analgesic generally indicated for relief of moderate to severe pain. References Mendelson, J., et al.: Clin. Pharmacol. Ther., 60, 105 (1996), Fudala, P., et al.: N. Engl. J. Med., 349, 949 (2003), Alho, H., et al.: Drug Alcohol Depend., 88, 75 (2007),

Impurity Naloxone Impurity G Applications Naloxone 3-Methyl Ether is an Intermediate for the synthesis of Labelled Naloxone (N285000), a specific opioid antagonist and narcotic antagonist. References Jasinski, D. R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L. F., et al.: Drugs, 27, 81 (1984), Hasson, M. M. A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)

Applications A labelled metabolite of Atomoxetine. References Creighton, C.J., et al.: Bioorg. Med. Chem. Lett., 14, 15, 4083 (2004)