Deuterated Compounds

Applications Pyrrole-d5 (CAS# 18430-85-8) is a useful isotopically labeled research compound.

Applications Intermediate in the production of labelled Dutasteride References Wlassoff, W., et al.: J. Pharm. Pharmacol., 59, 1549 (2007), Kumar, N., et al.: Bioorg. Med. Chem., 17, 5388 (2009),

Applications 2-(Tetrazol-1-yl)acetic Acid-13C2,15N is a reactant used in the preparation of labelled β-lactam antibiotics. References Nys, P. et al.: App. Biochem. Biotech., 88, 221 (2000); Won, J. et al.: App. Biochem. Biotech., 69, 1 (1998); Kostadinov, M. et al.: App. Biochem. Biotech., 33, 177 (1992)

Applications Benzoic Acid-d5 Ethyl Ester (cas# 54354-03-9) is a compound useful in organic synthesis.

Applications N-(Carboxymethyl)-N,N,N-trimethyl-d9-ammonium Chloride (CAS# 285979-85-3) is a useful isotopically labeled research compound.

Applications Labelled Tolazamide, an antidiabetic. References Welling, et al.: J. Pharmac. Sci., 71, 1259 (1982);

Applications 1,3-Dimethoxy-5-(propyl-2,2,3,3,3-d5)benzene is an intermediate used in the synthesis of Cannabidivarin-D5 (C175292), which is a labelled analogue of Cannabidivarin (C175390), a plant cannanbinoid and a homologue of Cannabidiol (C175300), the non psychoactive component of cannabis that exhibits anxiolytic properties. Cannabidivarin also has anticonvulsant effects on animals. References Amada, N., et al.: PeerJ., 1, e214 (2013); Guimaraes, F., et al.: Psychopharmacology, 100, 558 (1990); Malfait, A., et al.: P. Natl. Acad. Sci., 97, 9561 (2000)

Applications Uracil-6-d1 (CAS# 24897-51-6) is a useful isotopically labeled research compound.

Applications Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic. References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005)

Applications Ethylene Glycol Dicaprate-d4 is a deuterated version of Ethylene Glycol Dicaprate (E917474), a plasticizer for chloroethylene polymers. References Van V. G. J., et al.: Kunststoffe, 57, 561 (1967); Van V. G. J., et al.: Plastica, 19, 175 (1966)

Sodium acetate-13C2 is a plant metabolite that is produced by the metabolism of acetate. It has been postulated to be involved in plant defense against pathogens and pests. The 13C label was used to track the metabolite through various metabolic pathways, including phytoalexins, detoxification, and degradation. The unlabelled form of the molecule was used for chromatographic techniques to detect its presence in plants. The high values obtained from these methods were quantified and compared with known concentrations of phytuberin, a phytoalexin found in tobacco plants. The results suggest that this metabolite may play a role in plant pathogen resistance.

Applications Glycine-13C2,15N p-Toluenesulfonate is a by-product of an intermediate during the synthesis of m-Hydroxyhippuric Acid-13C2, 15N (H943127), a labelled m-Hydroxyhippuric Acid (H943125) which is a metabolite of caffeic and chlorogenic acids in human. References Booth, A., et al.: J. Biol. Chem., 229, 51 (1957); Gonthier, M., et al.: Biomed. Pharmacother., 60, 536 (2006)

Applications N-Fmoc-(13C9,15N)-L-Tyrosine O-Tertbutyl Ether is the isotope labelled protected form of L-Tyrosine (T899975), an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines (e.g. Norepinephrine HCl [N674500]) in human keratinocytes, and also for the synthesis of proteins and thyroid hormones. References Gülçin, ?.: Amino Acids, 32, 431 (2007); Langen, K., et al.: Nuc. Med. Biol., 29, 625 (2002); Schallreuter, K., et al.: J. Invest. Derm., 104, 953 (1995); Zhang, W., et al.: Neuropharmacology, 47, 438 (2004)

Applications Benzyl-alpha,alpha-d2 Alcohol (CAS# 21175-64-4) is a useful isotopically labeled research compound.

Applications N,N-Dimethyldodecylamine-d6 is the isotope labelled analog of N,N-Dimethyldodecylamine. N,N-Dimethyldodecylamine is used as a reagent in the synthesis of epoxy quaternary ammonium salt surfactants which exhibit potential antibacterial activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Liu, Y., et al.: J. Disper. Sci. Technol., 35, 1460 (2014)

Applications Diethyl-2,2,2,2',2',2'-d6-amine HCl (CAS# 1219805-68-1) is a useful isotopically labeled research compound.

Applications Labelled N-Nitrosopiperidine (N545370). A carcinogenic nitrosocompound. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bos, J., et al.: Cancer Res., 49, 4682 (1989), Wong, H., et al.: Carcinogenesis, 24, 291 (2003), Gonzalez-Mancebo, S., et al.: Mutat. Res., 558, 45 (2004), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 601 (2005),

Applications 2,3,5-Trimethylphenol-d11 (CAS# 362049-46-5) is a useful isotopically labeled research compound.

Applications Labelled Maleic Anhydride. A heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it is used in synthetic tensides, insecticides, herbicides and fungicides. References Hanafi, W.Z.A. et al.: Plast. Rub. Comp. Proc. Appl., 19, 175 (1993); Noma, K. et al.: Shik. Kyok., 36, 225 (1963); Augustin, M. et al.: Wissen. Zeitsch., 25, 5 (1976); Jiang, Q. et al.: Nongyao, 49, 257 (2010);

Applications Labelled 2-Aminothiazoline-4-carboxylic acid (A630330). Used in the manufacturing of L-tryptophan by enzymic reaction. References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),

Applications 4-Fluoro-1,3-dioxolan-2-one-d3 is the labeled version of 4-Fluoro-1,3-dioxolan-2-one (F591523)

Applications n-Hexyl Sec-Hexyl Phthalate-d4, is the labeled analogue of n-Hexyl Sec-Hexyl Phthalate (H297200), a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties. References Wang, Zh., et al.: Guocheng Gongcheng Xuebao, 5 (6), 670 (2005);

Applications N,N-Diisopropylamine-d14 is used in the synthesis of trideuterated propantheline bromide;Also, it is an intermediate used in the synthesis of Disopyramide-d14 Tosylate Salt (D493452), which is an anti-arrhythmic (class IA). Sodium channel blocker. References Buckley, P. H., et al.: J. Label. Compd. Radiopharm., 15, 657-664 (1978); Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986)

Applications 1,4-Butane-d8-dithiol (CAS# 1219805-46-5) is a useful isotopically labeled research compound.

Applications 1-Adamantan-d15-amine is a labeled NMDA-receptor antagonist. Antiviral; antiparkinsonian. References Vernier, V.G., et al; Toxicol. Appl. Pharmacol., 15, 642 (1969); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 12, 1 (1983)

Stability Hygroscopic Applications Tris(2-ethylhexyl) Phosphate-d51 is labelled Tris(2-ethylhexyl) Phosphate (T884650) which is used as a phosphorous flame retardant. Tris(2-ethylhexyl) Phosphate (T884650) is also used as a plasticizer in the preparation of a new potentiometric membrane sensor. References Ballesteros-Gomez, A. et al.: Anal. Chem., 85, 9572 {2013); Gholivand, M. et al.: Adv. Sci. Eng. Med., 5, 73 (2013);

Applications Hydrocinnamic-alpha,alpha-d2 Acid (CAS# 19136-97-1) is a useful isotopically labeled research compound.

Applications L-Phenyl-d5-alanine-N-FMOC (CAS# 225918-67-2) is a useful isotopically labeled research compound.

Applications 1,3-Dichlorobenzene (D4, 98%) (cas# 2199-70-4) is a useful research chemical.

Applications N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N,4-dimethyl-1-naphthalenemethanamine-d3 is an isotope labelled impurity of Terbinafine (T107500), an orally active, antimycotic allylamine and a specific inhibitor of squalene epoxidase. References Petranyi, G., et al.: Science, 224, 1239 (1984); Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985); Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999);

Applications Isotope labelled D-Fructose (F792500), a monosaccharide that naturally occurs in large number of fruits and plants. References Shum, M., et al.: Am. J. Physiol., 304, 197 (2013); Zeng, S.S., et al.: J. Pharma. Biomed. Anal., 76, 87 (2013);

Applications 1,4-Diethylbenzene-d14 (CAS# 1219803-64-1) is a useful isotopically labeled research compound.

Applications Labelled Disulfiram. It is used as rubber accelerator; vulcanizer; seed disinfectant; fungicide; alcohol deterrent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Child, C., et al.: Acta Pharmacol. Toxicol., 8, 305 (1952), Nash, N.G., et al.: Anal. Profiles Drug Subs., 4, 168 (1975),

Applications Ethyl Isobutyrylacetate-d6 (cas# 1216475-83-0) is a compound useful in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Bromoacetic-2-13C Acid is the isotope labelled analog of Bromoacetic Acid (B679075); a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970)

Applications Bis(2-Chloroethyl)Ether (D8, 98%) (cas# 93952-02-4) is a useful research chemical.

Applications Ethyl N-n-Butyl-d9-carbamate (CAS# 1276197-24-0) is a useful isotopically labeled research compound.

Applications Ethyl (5-Ethyl-2-pyridinyl)-1,1-d2-acetate (cas# 1189654-25-8) is a compound useful in organic synthesis.

Applications 1,2,4-Trimethylbenzene-d12 (CAS# 350818-61-0) is a useful isotopically labeled research compound.

Applications Labelled Hydrochlorothiazide (H714560). Hydrochlorothiazide is a carbonic anhydrase inhibitor as a diuretic. References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961), Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981),

Applications Isotope Labelled 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References LaMontagne, M.P. et al.: J. Med. Chem., 17, 519 (1974); Yoshizaki, S. et al.: Chem. Pharm. Bull., 37, 3430 (1989);

Applications Hexanoic-5,5-d2 Acid (CAS# 55320-68-8) is a useful isotopically labeled research compound.

Applications γ-Valerolactone-d3 is the isotope labelled analog of γ-Valerolactone. γ-Valerolactone is a naturally occurring chemical found in fruits and is frequently used as a food additive. It can be converted to liquid alkenes which can be used as transportation fuels. References Horvath, I.T., et al.: Green Chem., 10, 238 (2008); Bond, J.Q., et al.: Science, 327, 1110 (2010)

Stability Hygroscopic Applications Labelled dimethyl phosphorothiolate derivatives used as insecticides. References Suzuki, F., et al.: Jpn. Tokkyo Koho (1976), JP 51009007 B

Applications 5-[4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-chloro-4-fluorobenzoic Acid-d3 is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.

Applications Isotope labelled analog of α-D-Galactose 1-Phosphate, the phosphate conjugate of α-D-Galactose (G155260), a natural aldohexose which is ubiquitous in bacteria, plants, and animals, including human brains. References Sang, J.L., et al.: J. Bacteriol., 190, 7932 (2008);

Stability Hygroscopic Applications Methyl-d3 β-D-Glucuronide Sodium Salt is a compound useful in organic synthesis.

Applications n-Tricosane-d48 (CAS# 203784-75-2) is a useful isotopically labeled research compound.

Stability Volatile Applications rac 1,2-Diaminopropane-d3 is labelled rac 1,2-Diaminopropane which was used as model precursor in the electron induced deposition of amorphous carbon nitride films. It was also used to synthesize cage peroxide, 1,6-diaza-3,4,8,9-tetraoxa-11-methylbicyclo[4.4.2]dodecane. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wnuk, J., et al.: J. Phys. Chem., 113, 12345 (2009); Edward, J., et al.: Can. J. Chem., 77, 1057 (1999)

Applications Diisopropylcyanamide-D7 is an intermediate used in the synthesis of Disopyramide-d14 Tosylate Salt (D493452), which is an anti-arrhyrhmic (class IA). Sodium channel blocker; References Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986),

Applications Formamidine-13C Acetate (cas# 1215714-80-9) is a compound useful in organic synthesis.

Applications 3-Aminopropionamide-2,2,3,3-d4 HCl (CAS# 1276197-35-3) is a useful isotopically labeled research compound.

Applications 2-(Acetylamino)butanoic Acid-d5 is an intermediate of Isotope labelled L-2-Aminobutyric Acid (A602930) Receptor antagonist. References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995),

Applications Acridine (D9, 98%) (cas# 34749-75-2) is a useful research chemical. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Myristic Acid (D27, 98%) (cas# 60658-41-5) is a useful research chemical.

Applications Chemical building block used in the synthesis of more complex structures.

Applications (4E)-Octenedinitrile-1,8-13C2 (cas# 1185245-34-4) is a compound useful in organic synthesis.

Applications Uracil-15N2 can be used as a stable-isotopic standard to measure of post-replicative DNA metabolic and damage in brains of rodents. This compound can also be used for isotope tracing to determine the mechanism and stem-cell activity of 5-carboxycytosine decarboxylation. References Patel, J.P., et.al., Chem. Res. Toxicol., 28, 2352-2363, (2015); Schiesser, S., et.al., Angew. Chem. Int. Ed., 51,6516-6520, (2012);

Applications 1,4-Naphthoquinone-d6 (CAS# 26473-08-5) is a useful isotopically labeled research compound.

Applications A labelled metabolite of Temozolomide, an antineoplastic.

Applications Monocrotaline-d4 is labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),

Applications The toxicity of halogenated benzoic acids was found to be directly related to the compound's hydrophobicity. Toxicity and quantitative structure-activity relationships of benzoic acids to Pseudokirchneriella subcapitata. This is the labelled analog. References Moore, D., et al.: Environ. Toxicol. Chem., 16, 794 (1997), Zhao, Y., et al.: Sci. Total Environ., 216, 205 (1998), Fiorentino, A., et al.: J. Agric.Food Chem., 51, 1005 (2003),

Applications Chlorobenzene-3,4,5-d3 (CAS# 59164-11-3) is a useful isotopically labeled research compound.

Applications 1,2-Dichloroethylene (1,2-D2, 98%) Cis/Trans Mix (cas# 15075-90-8) is a useful research chemical. Chemical Name: 1,2-Dichloroethylene (1,2-D2, 98%) Cis/Trans Mix (cas# 15075-90-8) is a useful research chemical.