Deuterated Compounds

Applications Ethyl-1,1-d2-methylamine (CAS# 223459-63-0) is a useful isotopically labeled research compound.

Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N-(methyl-d3)amine (cas# 1189957-44-5) is a compound useful in organic synthesis.

Applications Benzyl 2-(2-Hydroxy-3-morpholinopropyl)hydrazinecarboxylate-d5 is an intermediate for the synthesis of 2-NP-AMOZ-d5 (N894952), which is a labelled derivatized of AMOZ (A634600), a metabolite of Nitrofuran. References Vroomen, L., et al.: Toxicol. Appl. Pharmacol., 95, 53 (1988), Delatour, T., et al.: J. Agric. Food Chem., 51, 6371 (2003), Stadler, R., et al.: Analyst, 129, 276 (2004),

Applications 1,3-Dibromo-5-fluorobenzene-d3 (CAS# 1219805-87-4) is a useful isotopically labeled research compound.

Applications Nitroethane-d5 (CAS# 57817-88-6) is a useful isotopically labeled research compound.

Applications 5-Hydroxy-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one-d3 is an intermediate for the synthesis of Alternariol Monomethyl Ether-d3 (A575771), labelled methyl este analog fo Alternariol. An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009)

Applications The microwace spectra of Dichloroacetic Acid-d1 consists of many weak absorption lines. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Van Zoeren, E., et al.: J. Mol. Struct., 97, 315-322 (1983);

Applications 2,2-Difluoroethylamine-d2 Hydrochloride is an intermediate used in the synthesis of Flupyradifurone-d5 (F598616), which is the labeled form of Flupyradifurone (F598615), can be used as an insecticide. References Anon, IP.com J., 12, 19 (2011)

Applications Trixylyl Phosphate-d10 is a deuterated form of Trixylyl Phosphate (T891900), which is used commercially as hydraulic fluids, flame retardants, and plasticizers. Trixylyl Phosphate inhibits the human ether-a-go-go-related gene (hERG) channel, which is a voltage-gated potassium (K+) channel involved in the repolarization of the cardiac action potential. References Chigwada, G., et al.: Polym. Degrad. Stab. 89, 85 (2005); Xia, M., et al.: Toxicol Appl Pharmacol 252, 250 (2011)

Applications Triphenylamine-d15 (CAS# 880462-20-4) is a useful isotopically labeled research compound.

Please enquire for more information about Esomeprazole-D6 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Nonanoic-6,6,7,7-d4 Acid (CAS# 1219795-27-3) is the labelled version of n-Nonanoic Acid (N649385(P)), which is commonly used in conjunction with glyphosate, a non-selective herbicide, for a quick burn-down effect in the control of weeds in turfgrass. It is also used in the preparation of plasticizers and lacquers. References Pline, W., et al.: Weed Technol., 14, 667 (2000); Frade, J., et al.: Anal. Bioanal. Chem., 395, 2167 (2009);

Applications A labelled ethylene oxide-DNA adduct. Ethylene oxide (EtO) is classified as a known human carcinogen. The formation of EtO-DNA adducts is considered as an important early event in the EtO carcinogenic process. References Walker, V., et al.: Cancer Res., 52, 4320 (1992), Wu, K., et al.: Chem. Res. Toxicol., 12, 722 (1999), van Sittert, N., et al.: Mutat. Res., 447, 27 (2000),

Stability Hygroscopic Applications Isotope labelled analogue of Guanosine (G837900), a constituent of nucleic acids. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Miles, et al.: Science, 142, 1458 (1963), Bugg, et al.: Biochem. Biophys. Res. Commun., 3, 436 (1968),

Applications 2,4-Dichlorobenzoic-d3 Acid (CAS# 1398065-99-0) is a useful isotopically labeled research compound.

Applications Ethynyl-2-13C-benzene, is the labeled analogue of Ethynylbenzene (E932150), which is an aromatic hydrocarbon, is important in the petrochemical industry as an intermediate in the production of styrene, which in turn is used for making polystyrene, a common plastic material. References Xiang, J., et al.: Tetrahedron Lett, 37, 5269 (1996);

Applications 1-Dodecane-d25-thiol (CAS# 869563-00-8) is a useful isotopically labeled research compound.

Applications 2-Fluoroaniline-4,6-d2,ND2 (CAS# 1219804-77-9) is a useful isotopically labeled research compound.

Please enquire for more information about Tiopronin-13C, d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 6-Methyl-5-hepten-2-one-1,1,1,3,3-d5 is an intermediate used in the synthesis of Geraniol-D5 (G367003), which is a deuterium labelled analog of Geraniol, which is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation. References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);

Applications p-Tolyl-d7 Isocyanate (CAS# 1219798-59-0) is a useful isotopically labeled research compound.

Applications A labelled antibacterial agent. References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),

Applications Heptanoic-7,7,7-d3 Acid (CAS# 156779-04-3) is a useful isotopically labeled research compound.

Please enquire for more information about 2-(Methyl-13C)-5-nitro(imidazole-2-13C-1,3-15N2)-1-ethanol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications n-Undecyl-1,1,2,2-d4 Alcohol (CAS# 1219803-47-0) is a useful isotopically labeled research compound.

Applications Phenol-2,4,6-d3,OD (CAS# 80441-87-8) is a useful isotopically labeled research compound.

Applications 2,3-Dichlorobenzamidyl Guanidine-13C2 (cas# 1185047-08-8) is a compound useful in organic synthesis.

Applications 4-Hydroxybenzophenone-d4 is an isotopic analog of 4-Hydroxybenzophenone (H829305), a metabolite of benzophenone (B204980). References Stocklinski, A. et al. Life Sciences 26, 365(1980)

Applications 2-(Ethyl-d3) Isonicotinamide is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent. References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),

Applications Griseofulvin-d3 is the labeled analogue of Griseofulvin (G787500), an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.Environmental contaminants; Food contaminants References Oxford, et al.: Biochem. J., 33, 240 (1939); Townley, E.R., et al.: Anal. Profiles Drug Subs., 8, 219 (1979)

Applications Dihydro-3-(3-pyridoyl)-2-(3H)-furanone-d4 is an intermediate in the synthesis of 1-(3-Pyridyl-d4)-1,4-butanediol (P992504). 1-(3-Pyridyl-d4)-1,4-butanediol is the labeled analogue of 1-(3-Pyridyl)-1,4-butanediol (P992500), a metabloite of NNK (M325750), a carcinogen that readily produces cancer in rats and hamsters. References Koenigs, L., et al.: Drug Metab. Dispos., 25, 1407 (1997); Gu, J., et al.: Toxicol. Appl. Pharmacol., 165, 158 (2000); Jalas, J., et al.: Chem. Res. Toxicol., 18, 95(2005); Zhu, L., et al.: Drug Metab. Dispos., 34, 1672(2006)

Applications (±)-Tetrahydro-2-furoic-d7 Acid (CAS# 1219798-42-1) is a useful isotopically labeled research compound.

Applications (±)-(1-Bromoethyl-2,2,2-d3)benzene (CAS# 23088-42-8) is a useful isotopically labeled research compound.

Applications Talaporfin-13C4-15N is labelled Talaporfin which is a photosensitizer used in photodynamic therapy. References Yoshinori, N., et al.: Photochem. Photobio., 85, 714 (2009); Gomer, C., et al.: Cancer Res., 56, 2355 (1996)

Applications Decanoic-2,2-d2 Acid (CAS# 62716-49-8) is a useful isotopically labeled research compound.

Applications Phenylboronic Acid-13C6 is the isotope labelled 13C6 analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods. References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)

Phenol-d6 is a chemical compound that can be used for wastewater treatment. It is a high molecular weight compound that is soluble in water and does not dissolve in organic solvents. Phenol-d6 is used to remove chloride from wastewater, which results from the reaction of chlorine with organic compounds. The functional groups on phenol-d6 react with the chloride ions, forming insoluble hydrochloric acid, which precipitates from the solution. Phenol-d6 has been shown to bind to muscle proteins and has been used as a model for studying muscle reactions. Phenol-d6 also reacts with activated intermediates, such as nitrite and nitrate, in order to form stable products that are easier to analyze. Phenol-d6 also has vibrational properties and can be ionized by electron capture or mass spectroscopy.

Applications N'-[(2-Chloro-5-thiazolyl)methyl]-N-nitro-carbamimidothioic Acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1(C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops. References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications Isotope labelled Quinoline (Q700380), which is a starting material that may be transformed by bacteria and fungi to produce intermediates useful for the synthesis of drugs. Used in the synthesis of tertiary alcohol modulators of RORγ (1) which appears to have various biological functions. Also derivatives of quinoline have been seen to promote anticancer, antibacterial and antiviral activity, however quinoline itself is often seen as an environmental contaminant (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Kummer, D. et al.: Bioorg. Med. Chem. Lett. 2017 Feb 21.2. Ramirez-Prada, J. et al.: Eur J Med Chem. 2017 Mar 16;131:237-254.3. Mestankova, H. et al.: Water Res. 2016 Apr 15;93:110-20

p-Cresol-2,3,5,6-d4 is a metabolite of p-cresol. It is produced by the intestinal microflora of humans and animals. This compound has been detected in urine samples of patients with liver disease and in the feces of healthy human volunteers. p-Cresol-2,3,5,6-d4 is an aromatic amino acid that can be synthesized from toluene or by hydroxyation of an aromatic amino acid by escherichia coli. The enzyme responsible for this reaction is called phenylalanine hydroxylase.

Applications 1,1-Dimethylethyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate-d4 is an isotope labelled intermediate in the synthesis of labelled Flupentixol. References Panteleev, J., et al.: Synlett., 26, 953 (2015); Liang, Y.K., et al.: Euro. J. Med. Chem., 84, 505 (2014);

Stability Hygroscopic, Light Sensitive, Temperature Sensitive Applications 3-Deoxyglucosone-13C6, is the labeled anologue of 3-Deoxyglucosone (D239150), an intermediate in the Maillard reaction of proteins with glucose, which is metabolised to 3-Deoxyfructose. An intermediate in the formation of pyrraline, which might contribute to a pathological effect, such as carcinogenesis. References Kato, H. et al.: Agric. Biol. Chem., 51, 683 (1987), Hayase, F. et al.: J. Biol. Chem., 264, 3758 (1989), Kato, H. et al.: Biochimica et Biophysica Acta, 1035, 71 (1990)

Applications Intermediate in the preparation of labelled α-Carboline derivatives

Applications 1,3-Propane-d6-diamine, Dihydrochloride is used in the study of trimethylsilylated di and polyamine and their isotopically labelled analogs. References Smith, R. G., et al.: J. Org. Chem., 43, 2178 (1978)

Applications Isotope labelled Isopropyl DL-Mandelate is used in nonporous silica/alumina amorphous material. Pregabalin (P704800) impurity. References Wang, Z. et al.:; ACS Catal., 3, 1573 (2013);

Applications Cyanamide-13C (cas# 21420-35-9) is a compound useful in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Isotope labelled Isonipecotic Acid Methyl Ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds. References Kim, E.-K. et al.: Yak. Hoechi, 48, 182 (2004); Tanitame, A. et al.: Bioorg. Med. Chem. Lett., 14, 2857 (2004);

Applications N-Methyl Lacosamide-d3 is the labeled analogue of N-Methyl Lacosamide (M315210), a methly analogue of Lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant. References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997); Barton, M., et al.: Epilepsy Res., 47, 217 (2001); Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006); Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007)

Applications 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide-d4 is labelled 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure. References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011);

Applications L-Alanine-d7 (CAS# 74280-71-0) is a useful isotopically labeled research compound.

Applications 3,5-Dimethylphenol-2,4,6-d3,OD (CAS# 1219803-59-4) is a useful isotopically labeled research compound.

Applications Nandrolone Octanoate-d15 is the isotope analog of Nandrolone Octanoate. Nandrolone Octanoate is a metabolite of nandrolone (N315000), which is an anabolic steroid. References Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990), Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008),

Applications 2-Bromoethyl-4-nitrophenyl Ether-d4 (cas# 1190017-10-7) is a compound useful in organic synthesis.

Applications D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in infant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule. This is the labeled analog. References Van Leeuwen, S. et al.: J. Agri. Food Chem., 60, 12553 (2012); Geoghegan, K. et al.: Prot. Express. Purif., 87, 27 (2013);

Applications Used as an insecticide. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);

Applications D-Cellobiose-13C12 is the isotope labelled analogue of D-Cellobiose (C255000), a disaccharide consisting of two glucose in a beta 1-4 linkage. References Yang, S.Q.. et al.: Carbo. Poly., 92, 784 (2013);

Applications Labelled Sulfamonomethoxine. Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia. References Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995)

Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0. References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),

Applications Iodoethane-1-d1 (CAS# 3652-81-1) is a useful isotopically labeled research compound.

Stability Hygroscopic Applications Tiglylcarnitine-d3 is labelled Tiglylcarnitine (T793780), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Tiglylcarnitine can be diagnostic for a number of ß-oxidation defects. References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications Labelled Aldicarb (A514650). Aldicar is used as an insecticide. Used in Pesticide detection. References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),

Applications 2-(2-Aminoethoxy)anisole-d3 (cas# 1189881-28-4) is a compound useful in organic synthesis.

Applications 2,4-Dihydroxybenzophenone-d5 is deuterium labelled of 2,4-Dihydroxybenzophenone (D451780), which is a metabolite of Benzophenone (B204980). Benzophenone can be used to synthesize antihistamines, hypnotics and insecticides. References Li, M.H., et al.: Toxicol. Environ. Chem., 94, 566 (2012); Leon, Z.. et al.: Anal. Bioanal. Chem., 398, 831 (2010); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)

Applications 4'-Chloroacetophenone-2',3',5',6'-d4 (CAS# 284474-50-6) is a useful isotopically labeled research compound.

Applications Anthracene-d10 is an isotope labelled analogue of Anthracene (A678400), an polycyclic aromatic hydrocarbon found readily as an component in coal tar. Anthracene is also used in the preparation of various dyes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications n-Hexyl 4-Methyl-2-pentyl Phthalate, is the labeled analogue of n-Hexyl 4-Methyl-2-pentyl Phthalate (H297165), a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties. References Wang, Zh., et al.: Guocheng Gongcheng Xuebao, 5 (6), 670 (2005);