Deuterated Compounds

Applications Methyl 2-Hydroxybenzoate-3,4,5,6-d4 (CAS# 1219802-12-6) is a useful isotopically labeled research compound.

Stability Very Hygroscopic Applications Labelled Sodium Trifluoroacetate, a compound used as an intermediate for various pharmaceutical, agricultural and chemical applications.

Applications 3-Benzyloxy-α-(N-butyryl-d3)-aminopropionitrile (cas# 1216615-94-9) is a compound useful in organic synthesis.

Applications Rabeprazole-D4 Sulfide is an intermediate in the synthesis of Rabeprazole-d4 (R070492). Rabeprazole-D4 Sulfide is an isotope-labeled analogue of Rabeprazole Sulfide (Rabeprazole EP Impurity B), which is a metabolite of Rabeprazole (R070500). References Morii, M., and Takeguchi, N.: J. Biol. Chem., 268, 21553 (1993); Yasuda, S., et al.: Int. J. Clin. Pharmacol. Ther., 32, 466 (1994); Cloud, M.L., et al.: Dig. Dis. Sci., 43, 993 (1998)

Applications Benzophenone-13C was useful for studying the behaviour of cumulene molecules when absorbed in faujasite zeolite pores. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Shibata, S., et al.: Bull. Chem. Soc. Japan, 93, 663 (2020)

Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist. References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);

Applications 2,4-Difluorotoluene-3,5,6-d3 (CAS# 1219798-79-4) is a useful isotopically labeled research compound.

Applications 1-Octanol-d17, is the labeled analogue of 1-Octanol (O237900), which is an fatty acid alcohol that is used industrially to form various synthetic intermediate and pharmaceuticals. References Nagaraja, N., et al.: J. Entomol. Res., 37, 29 (2013); Luang, S., et al.: J. Biol. Chem., 288, 10111 (2013);

Applications Cyclohexanecarboxylic-1-d1 Acid (CAS# 933-37-9) is a useful isotopically labeled research compound.

Applications Sodium Propionate-d5 (CAS# 202529-18-8) is a useful isotopically labeled research compound.

1a-Hydroxy vitamin D2 is a synthetic analog of vitamin D. It has been shown to have anti-cancer effects in vitro and in vivo by inducing apoptosis in prostate cancer cells. 1a-Hydroxy vitamin D2 may also be useful for the treatment of obesity, metabolic syndrome, and type 2 diabetes mellitus. The drug may be an effective treatment for chronic kidney disease patients with low levels of the enzyme matrix metalloproteinase (MMP), as it inhibits MMP activity. This drug binds to calcium ions and alters cellular adhesion, which could lead to cardiac arrhythmias.

Applications Octylamine-d17 is the isotope labelled analog of Octylamine. Octylamine is used as a reactant in the synthesis of 2H-indazoles and 1H-indazolones which are used as myeloperoxidase(MPO) inhibitor. E0 References Roth, A., et al.: Bioorg. Med. Chem., 22, 6422 (2014);

Please enquire for more information about 5-Hydroxy methyl tolterodine D14 formate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 4-Fluorobenzyl-d6 Chloride (CAS# 1219804-13-3) is a useful isotopically labeled research compound.

Applications Diphenyl p-Hydroxyphenyl Phosphate-d10 is the deuterated form of Diphenyl p-Hydroxyphenyl Phosphate (D492418), which is a phosphorus flame retardant additive. References Kojima, H., et al.: Toxicology Letters, 245, 31-39. (2016);

Applications Labelled 2-Furfurylthiol Acetate (F864600). 2-Furfurylthiol Acetate is a sulfur-substituted furan derivative used as flavouring agent. 2-Furfurylthiol Acetate is a precursor to furfurylmercaptan which is very prone to oxidation to the disulfide. We will provide a detailed procedure for the preparation of the thiol from the thioacetate with spectral data upon request. References Engel, K., et al.: J. Agric. Food Chem., 39, 2249 (1991), Jones, M., et al.: J. Exp. Bot., 55, 1903 (2004), Gershater, M., et al.: J. Biol. Chem., 282, 21460 (2007),

Applications Labelled Bromoacetic Acid. Bromoacetic Acid is a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970);

Applications Pentamidine-d4 2HCl (pentane-1,1,5,5-d4) (CAS# 1276197-32-0) is a useful isotopically labeled research compound.

Applications 16-COOH Mitragynine - D3 is the labeled 16-COOH Mitragynine(C724820) which is a derivative of Mitragynine(M373550) which is a neurochemical, having both stimulant and opiate-like effects depending on the dosage. Currently, Mitragynine is being investigated for its ability to treat hard drug addiction. References Kikura-Hanajiri, R., et al.: For. Toxicol., 27, 67 (2009); Bjoernstad, K., et al.: Clin. Toxicol., 47, 566 (2009); Parthasarathy, S., et al.: Anal. Bioanal. Chem., 397, 2023 (2010);

Applications Labelled Farnesyl Pyrophosphate. Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras. References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),

Applications DL-4-Hydroxyphenylalanine-3,3-d2 (CAS# 35693-18-6) is a useful isotopically labeled research compound.

Applications β-Cyclodextrin Deuterated is an isotope analog of β-Cyclodextrin (C987830), which is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-Cyclodextrin is commonly used to produce HPLC columns allowing chiral enantiomers separation. References Motoyama, A. et al.: J. Pharmac. Biomed. Anal., 28, 97 (2002); Nakamura, N. et al. Biotechnol. Bioeng., 19, 87 (1977); Riddle, L. A. et al.: J. Chrom. Sci., 45, 330 (2007);

Applications Cyanoacetic Acid-13C2 is an intermediate for the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat. References Maes, L., et al.: J. Parasitol., 74, 931 (1988)

Applications Labelled Mecoprop (M203052). Herbicide. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gagne, F., et al.: Environ. Res., 103, 238 (2007), LaChapelle, A., et al.: Reprod. Toxicol., 23, 20 (2007),

Please enquire for more information about N-Dodecyl-D25-Beta-D-Maltoside including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications (+)-Echimidine N-Oxide-D3 is a labelled analogue of (+)-Echimidine N-Oxide (E325585), a hepatotoxic pyrolizidine alkaloid that is present in honey, pollen, and comfrey tea leaves. References Cao, Y., et al.: J. Food Comp. Anal., 29, 106 (2013); Hirono, I., et al.: J. Nat. Cancer Inst., 63, 469 (1979); Oberlies, N., et al.: Pub. Health Nut., 7, 919 (2004)

Applications Intermediate for the synthesis of Eprosartan-d3.

Please enquire for more information about Hydroxy tolbutamide-d9 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 1-Cyclohexyl-1-(4-benzyloxycyclohexyl)-2-(2-pyridinyl)ethanol-d11_x000D_(Mixture of Diastereomers) (cas# 1189891-05-1) is a compound useful in organic synthesis.

Applications An intermediate in the production of labelled fluorothymidine derivatives References Roberts, G., et al.: Biochem. Pharmacol., 46, 2209 (1993), Hatano, A., et al.: Bioorg. Med. Chem., 16, 3866 (2008),

Applications rac 3-Hydroxybutyric Acid-d2 Sodium Salt is the labeled analogue of rac 3-Hydroxybutyric Acid Sodium Salt (H833020), an optically active 3-hydroxybutyric acids are key intermediates of the biosynthesis and metabolism of fatty acids and exist widely in biological systems. References Freeman, J., et al.: Pediatrics, 102, 1358 (1998), Thio, L., et al.: Neurology, 54, 325 (2000), Rho, J., et al.: Epilepsia, 43, 358 (2002)

Please enquire for more information about 7,8-dihydroxy-7,8-dihydrovitamin D3 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Adipic Acid-D8 is a labelled analogue of Adipic acid (A291590), a chemical used in the synthesis of nylon. References Kim, Y. et al.: Ind. Eng. Chem. Res., 51, 15801 (2012)

Applications N-(4-Nitrobenzoyl)-D-serine Quinine Salt is an intermediate used in the synthesis of D-Serine-2,3,3-d3 (S270977), which is derived from 2-Chlorobenzyl Chloride (C364225), which is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity. References Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015); Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)

Applications Isopropyl Diphenyl Phosphate-d10 is a labelled analogue of Isopropyl Diphenyl Phosphate (I824470) which is a chemical reagent used in the synthesis of H-phosphonate synthesis of oligonucleotides. Also used in the preparation of flame retardants. References Butt, C. et al.: Env. Sci. Tech., 48, 10432 (2014); Powles, N. et al.: Prg. Biomol. Chem., 10, 5940 (2012);

Applications Dodecylphosphocholine (D38, 98%) (cas# 130890-78-7) is a useful research chemical.

Applications Benzyl-alpha,alpha-d2-amine (CAS# 15185-02-1) is a useful isotopically labeled research compound.

Applications Daminozide-d4 is labelled Daminozide which is a plant growth regulator. Used as a standard for Pesticide detection, and cannabis testing. References Moriya, M., et al.: Mutation Res. Genetic Toxicol. Testing, 116, 185 (1983); Rose, N., et al.: J. Med. Chem., 55, 6639 (2012); Narayanan, V., et al.: Analusis, 21, 107 (1993)

Applications 2-Nitroaniline-3,4,5,6-d4 (CAS# 204244-80-4) is a useful isotopically labeled research compound.

Applications 2,4,6-Trimethyl-5-nitrobenzene-d11 (cas# 1126138-12-2) is a compound useful in organic synthesis.

Applications 1,4-Butane-2,2,3,3-d4-diamine 2HCl (CAS# 88972-24-1) is a useful isotopically labeled research compound.

Stability Hygroscopic Applications Labelled Phosphocholine Chloride, a specific promoter of heparin and serum β-lipoprotein interaction. Phosphocholine Chloride protected the membranes of platelets, erythrocytes, and lysosomes against the labilizing action of various known membrane labilizers. References Mookerjea, S. et al.: Biochem. Res. Biophys. Res. Comm., 53, 580 (1973); Caputi, A.P. et al.: Boll. Chim. Farmac., 117, 553 (1978):

Applications Labelled Endosulfan Sulfate, a pesticide used in the control and protection of plant and vegetation. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Weston, D. et al.: Env. Sci. Tech., 38, 2752 (2004); Antonious, G. et al.: Env. Tox. Chem., 16, 644 (1997);

Applications 2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of Lapatinib-d7 Dihydrochloride (L175807), which is a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic;Also, it is used in the preparation of 4-Aminoquinazolines as EGFR and HER-2 inhibitors. References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005); Tung, R.: PCT Int. Appl. (2008), WO 2008024439 A2 20080228

Applications Isotope labelled Formamide is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to “flow”. References Chomczynski, P.: Nuc. Acids Res., 20, 3791 (1992); Ma, X. & Yu, J.: Acta Polym. Sinica 2, No vol. given, 240 (2004); Rodriguez-Gonzalez, F., et al.: Polymer, 44, 1517 (2003); Shi, Q., et al.: Polym. Degrad. Stabil., 96, 175 (2011)

Applications n-Hexylbenzene-2,3,4,5,6-d5 (CAS# 1219799-07-1) is a useful isotopically labeled research compound.

Applications n-Nonanoic-9,9,9-d3 acid is labelled n-Nonanoic Acid (N649385) which is commonly used in conjunction with glyphosate, a non-selective herbicide, for a quick burn-down effect in the control of weeds in turfgrass. It is also used in the preparation of plasticizers and lacquers. References Pline, W., et al.: Weed Technol., 14, 667 (2000); Frade, J., et al.: Anal. Bioanal. Chem., 395, 2167 (2009)

Applications Formetanate-d6, Hydrochloride (cas# 1185240-24-7) is a compound useful in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications D-Tyrosine-d2 is deuterium labelled D-Tyrosine (T899970). D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces. References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011)

Applications Verapamil-d3 Hydrochloride is the labeled analogue of Verapamil Hydrochloride (V125000), which is a calcium channel blocker, antihypertensive, antianginal, and antiarrhythmic (class IV). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981); Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)

Applications 4-Bromotoluene-2,3,5,6-D4 is used in the synthesis of some deuteriated benzene derivatives like isotopically labelled ZD4054 used to support the development of drug metabolism and pharmokinetics program. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bergin, J. A., et al.: Journal of Label. Compds Radiopharm., 50, 431 (2007); Renaud, R. N., et al.: Canadian J. Chem., 39, 21 (1961)

Applications Isotope labelled Molinate (M486477), which is a herbicide that is used to control broad-leaved and grassy plants in rice and other crops (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References 1. Nacher-Mestre, J. et al.: J. Agri. Food. Chem. 2014 Mar 12;62(10):2165-742. Sugrue, E. et al.: Appl. Environ. Microbiol. 2015 Apr;81(7):2612-24.

Applications 5-Ethyl-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole-d5 is an isotope labelled impurity of Eletriptan (E505000), a serotonin 5-HTIB/ID receptor agonist and an antimigraine agent. References Madasu, S. B., et al.: Beilstein. J. Org. Chem., 8, 1400 (2012); Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998), Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999), Goadsby, P.J., et al.: Neurology, 54, 156 (2000)

Applications (±)-2-Ethylhexyl-d17 Acetate (CAS# 1219802-70-6) is a useful isotopically labeled research compound.

Applications Cuprous Cyanide-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications 2-[[[[1-(Methyl-d3)ethyl-1,2,2,2-d4]amino]sulfonyl]amino]-benzoic Acid Methyl Ester is an intermediate in the synthesis of Bentazon-d7 (B120583). Bentazon-d7 is deuterium labelled Bentazon (B120580), which is a herbicide. References Ghirardello, D., et al.: Environ. Sci. Technol., 44, 9010 (2010); Frihauf, J., et al.: Weed Technol., 24, 262 (2010); Rotroff, D., et al.: Toxicol. Sci., 117, 348 (2010)

Applications (R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-(4-trifluoromethoxybenzyl-d2-oxy)propyl-3,3-d2 Benzoate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug. References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Applications Labelled 2-acetylthioethanesulfonic acid. Mesna (M225750) impurity.

Applications m-Toluidine-d9 (CAS# 352431-22-2) is a useful isotopically labeled research compound.