Deuterated Compounds

Applications 5-Bromo Pentane-1,1,1,2,2,3,3,4,4-d9 is a isotope labeled building block.

Stability Hygroscopic Applications Trigonelline-d3 HCl is deuterium labelled Trigonelline HCl. Trigonelline HCl has utility in developing site-specific system that delivers drugs to the brain. It has also been suggested as a potential anti-Alzheimer disease agent. References Bodor, N., et al.: J. Med. Chem 26, 313 (1983); Makowska, J., et al.: J. Chromatogr. B 968, 101 (2014)

Applications n-Butyl-d9-benzene (CAS# 65087-59-4) is a useful isotopically labeled research compound.

Applications Bromoethane-1,2,2-d3 (CAS# 23705-69-3) is a useful isotopically labeled research compound.

Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),

Applications Benzyl-d7-amine HCl (CAS# 352431-27-7) is a useful isotopically labeled research compound.

Please enquire for more information about 3-Hydroxy Benzopyrene-d11 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications A labelled intermediate of Irbesartan (I751000). References Gillis, J., et al.: Drugs, 54, 885 (1997), Chando, T., et al.: Drug Metab. Disps., 26, 408 (1998), Hines, J., et al.: Eur. J. Pharmacol., 384, 81 (1999)

Applications N-Desmethyl Nefopam-D5 is deuterium labelled analogue of N-Desmethyl Nefopam (D422355), which is the main metabolite of Nefopam (N389418), which is a non-opioid non-steroidal centrally acting analgesic. References Chawla, J., et al.: Ther. Drug Monit., 25, 203 (2003); Aymard, G., et al.: Pharmacol. Toxicol., 92, 279 (2003); Yoon, J., et al.: Korean J. Anesthesiol., 69, 161 (2016); Petrault, M., et al.: Fundam. Clin. Pharmacol., 31, 194 (2017);

Applications 1-Bromohexane-1,1-d2 (CAS# 78904-38-8) is a useful isotopically labeled research compound.

Applications A labelled form of Pirimicarb (P508768) which is a pesticide which is useful in cannabis testing kits as a component of pesticide mixes (P698240). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tsuchiyama, T.; et al.: Journal of Chromatography A, 1524, 233 (2017).

Applications 4-Hydroxyphenylacetic-d6 acid is deuterium labelled 4-hydroxyphenylacetic acid (H949060), which is a compound found in olive oil. References Shu, Y., et al.: Guangdong Huagong, 37, 108 (2010); Papadopoulos, G., et al.: J Am Oil Chem Soc, 68, 669 (1991),

Applications (S)-Carbidopa Methyl-d3 Ester N-cyclohexylidene is the labeled analogue of (S)-Carbidopa Methyl Ester N-cyclohexylidene (C176015), an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase. References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963)

Applications Labelled Iprodione. Fungicide. References Lacroix, L., et al.: Phytiatr.-Phytopharm., 23, 165 (1974), Brenneman, T.B., et al.: Plant Dis., 71, 546 (1987),

Applications Methyl Salicylate-13C6 is an intermediate for the synthesis of Olsalazine-13C12 Sodium Salt (O586002), which is labelled Olsalazine (O586000). Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis. References Willoughby, C.P., Gut, 23. 1081 (1982), Scand, J., et al.: Gastroenterol, 20, 607 (1985), Wadworth, A.N., et al.: Drugs, 41, 647 (1991)

Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5

Applications 1-Bromopropane-2,2-d2 (CAS# 40422-15-9) is a useful isotopically labeled research compound.

Applications 1,2,4-Trimethyl 13C6-benzene is a labelled aromatic standard. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Diethyl 3,7-Bis(formyloxy)-25-methyl-cholestane-26,27-dioic Acid Ester-d3 is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid. References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)

Applications 2,4-Diaminotoluene (D416780). Aromatic amines likely to have high carcinogenic potency. QSARs of aromatic amines. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Franke, R., et al.: Carcinogenesis, 22, 1561 (2001), Benigni, R., et al.: Chem. Rev., 105, 1767 (2005), Benigni, R., et al.: Environ. Mol. Mutagen., 50, 152 (2009),

Applications Diethyl-d10-amine HBr (CAS# 1219803-53-8) is a useful isotopically labeled research compound.

Applications A labelled metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer. References Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);

Applications 4-[[6-Chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile-d8 is an intermediate from the synthesis of Etravirine-d8 (E937003). Etravirine-d8 is a novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection. References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008); Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008)

Applications A deuterated intermediate in the synthesis of Carisoprodol.

Applications A labelled metabolite of Carbon Disulfide. References Johnson, D., et al.: Chem. Res. Toxicol., 9, 910 (1996), Omae, K., et al.: Occup. Environ. Med., 55, 468 (1998),

Applications 4-Fluorobenzyl-2,3,5,6-d4 Chloride (CAS# 1219804-10-0) is a useful isotopically labeled research compound.

Applications 1-Ethoxyethanimine-D3 Hydrochloride is an intermediate in the synthesis of Secnidazole-d3 (S225003), which is a labelled Secnidazole (S225000). Analog of Metronidazole. Antiamebic. Antiprotozoal (Trichomonas). References Cosar, C., et al.: Arzneim.-Forsch., 16, 23 (1966), Videau, D., et al.: Br. J. Vener. Dis., 54, 77 (1978), Symonds, J., et al.: J. Antimicrob. Chemother., 5, 484 (1979),

Applications 2-(3,4-Dihydroxyphenyl)ethyl-1,1-d2-amine HCl (CAS# 83008-33-7) is a useful isotopically labeled research compound.

Applications n-Pentyl-5,5,5-d3 Alcohol (CAS# 64118-19-0) is a useful isotopically labeled research compound.

Applications Butyric-3,3-d2 Acid (CAS# 64833-96-1) is a useful isotopically labeled research compound.

Applications Adamantane-d16 is used in the fast catalytic hydroxylation of hydrocarbons with ruthenium porphyrins. Unlabeled adamantane derivatives have been used to treat influenza, as well as serve as NMDA receptor channel blockers for a wide range of pharmaceutical application. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wang, C. et al.: Inorg. Chem. 45, 4769 (2012); Thomas. A. et al.: J. Neurosci., 25, 3312 (2005); Deyde, V. et al.: Exp. Rev. Mol. Diag., 9, 493 (2009);

Applications n-Decyl-d21-trimethylammonium Bromide (CAS# 1515861-67-2) is a useful isotopically labeled research compound.

Applications Ethyl-beta,beta,beta-d3-benzene (CAS# 2618-00-0) is a useful isotopically labeled research compound.

Applications n-Tridecyl-d27 Alcohol (CAS# 203633-18-5) is a useful isotopically labeled research compound.

Chlorobenzene-4-d1 is a deuterium labeled chlorobenzene that has been used in the determination of quadrupole coupling constants. The isotopologue is useful for measuring the anisotropic constant of the quadrupole coupling, which is determined by the relative orientation between the two quadrupoles. This isotopologue has also been used to measure the constant of a quadrupole with anisotropic constants.

Applications Pyridine-2,6-d2 (CAS# 17265-96-2) is a useful isotopically labeled research compound.

Stability Hygroscopic Applications N,N'-Diphenylguanidine-d10 is the labeled version of 1,3-Diphenylguanidine (CAS 102-06-7), which is a useful intermediate. N,N'-Diphenylguanidine-d10 is also a rubber vulcanizing acclerator.

Applications n-Butylamine-d11 DCl (CAS# 347841-81-0) is a useful isotopically labeled research compound. Chemical Name: n-Butylamine-d11 DCl (CAS# 347841-81-0) is a useful isotopically labeled research compound.

Applications Labelled Quipazine maleate (Q797500). Quipazine maleate is a non-selective serotonin receptor agonist. Quipazine increases renin release by a peripheral hemodynamic mechanism. References Elliott, P.J., et al.: Neuropharmacol., 29, 949 (1990), Hashimoto, K., et al.: Eur. J. Pharmacol., 180, 273 (1990),

Applications Adipic Acid-13C6 is labelled Adipic Acid (A291590) which is primarily used in the synthesis of nylon. It has been used as a reagent in the solid-state polymerization of nylon analogs. References Kim, Y. et al.: Ind. Eng. Chem. Res., 51, 15801 (2012)

Applications labelled Wittig reagent. References Tsuchida, K., et al.: J. Med. Chem., 49, 80 (2006),

Applications Bis(m-cresyl) p-Cresyl Phosphate-d7 is Bis(m-cresyl) p-Cresyl Phosphate (B419225), an isomer of Tricresyl phosphate (TCP) which is used as an anti-wear additive in aircraft turbine engine oil. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References De Nola, G., et al.: J. Chrmoat. A, 1200, 211 (2008)

Fmoc-[15N]Val-OH is an epidermal growth factor receptor (EGFR) ligand that can be used to identify phosphorylation sites on EGFR. Fmoc-[15N]Val-OH binds to the tyrosine kinase domain of the EGFR and is phosphorylated by the intracellular protein tyrosine kinases, which leads to receptor activation. This compound has been shown to have a high affinity for human epidermoid carcinoma cells and can be used in cancer research as a potent and selective ligand. Fmoc-[15N]Val-OH is also known as a growth factor and has been shown to stimulate a number of cellular responses such as cell proliferation, migration, differentiation, and adhesion.

Applications Mepanipyrim Phenyl-d5 is deuterium labelled Mepanipyrim (M223600).Mepanipyrim (M223600) is an anilinopyrimidine fungicide which have been used in the management of fungal diseases in strawberries. References Tetada, M., et al.: Toxicol. Appl. Pharmacol., 154, 1 (1999); Hauke, K., et al.: Commun. Agri. Appl. Biol. Sci., 69, 743 (2004);

Applications Dimethyl Heptanedioate-2,2,6,6-d4 (CAS# 120811-82-7) is a useful isotopically labeled research compound.

1-Hydroxy-25-Fluorovitamin D3 (1HFVD) is a fluorinated form of vitamin D3. It is used to treat severe rickets, which is the most common cause of bone deformities in children. 1HFVD is absorbed by intestinal cells and transported to the liver where it binds to cytosolic receptor protein. It then enters the bloodstream and binds to vitamin D receptors in bone cells, stimulating the uptake and retention of calcium. 1HFVD does not require labeling because it does not contain any radioactive isotopes, unlike other forms of vitamin D.

Applications Labelled TEPA (T776600). Used as insect chemosterilant; in dyeing. Antineoplastic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gaines, et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969), Huitema, A., et al.: Br. J. Clin. Pharmacol., 51, 61 (2001), Jinno, H., et al.: Drug Metab. Dispos., 31, 398 (2003),

Applications Cyclopropane-2,2,3,3-d4-carboxylic Acid (CAS# 89924-82-3) is a useful isotopically labeled research compound.

Applications Ledipasvir-d6 is labelled Ledipasvir (L320100) which is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion. References Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)

Applications Isotope labelled O,O-Diethyl Dithiophosphate-d10 is used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Millard, C., et al.: J. Neurochem., 64, 1909 (1995), Nicolet, Y., et al.: J. Biol. Chem., 278, 41141 (2003), Casida, J., et al.: Chem. Res. Toxicol., 17, 983 (2004),

20% by weight in water. 98 atom % 13C

Applications 9-cis-Retinyl Stearate-d5, is the labeled analogue of 9-cis-Retinyl Stearate (R275600), a fatty acid ester of Retinol isomer, found mainly in the retina. References Bridges, C.D.B., et al.: Methods Enzymol., 81, 463 (1982),

Applications Testosterone Heptanoate-6,6,7,7,7-d5 (CAS# 1263095-31-3) is a useful isotopically labeled research compound.

Applications Isotope labelled Methiocarb Sulfoxide acts as a pesticide which is used in the protection of crops from insects and fungus. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wong, J. et al.: J. Agri,. Food. Chem., 58, 5897 (2010); Ghini, S. et al.: Arch. Env. Cont. Toxicol., 47, 479 (2004);

Applications L-Valine (1-13c, 99%) (cas# 81201-85-6) is a useful research chemical.

Applications A labelled metabolite of ethanol in humans and a potential biomarker of acute alcohol intake. References Jones, A., et al.: Forensic Sci. Int., 45, 217 (1990), Schmitt, G., et al.: J. Anal. Toxicol., 19, 91 (1995), Dahl, H., et al.: J. Anal. Toxicol., 26, 201 (2002), Stephanson, N., et al.: Ther. Drug Monit., 24, 645 (2002), Helander, A., et al.: Clin. Chem., 50, 936 (2004),

Applications 4-Hydroxybenzhydrazide-d4 Major is labelled 4-Hydroxybenzhydrazide which works as an indicator in the determination of carbohydrates. Tissue (liver) bounded 4-Hydroxybenzhydrazide, the acid-hydrolyzable side chain of Nifuroxazide (N458500) can be used as a marker to monitor it’s use as an antibiotic in chicken. References Lever, M., et al.: Anal. Biochem., 139, 205 (1984); Rocco, M., et al.: Anal. Biochem., 377, 251 (2008); Gao, F., et al.: J. Sci. Food Agr., 93, 2172 (2013)

Applications Methyl Methacrylate-d5 (CAS# 55935-46-1) is a useful isotopically labeled research compound.

Applications bis(2-Chloroethoxy)-d8-methane (cas# 93966-78-0) is a useful research chemical.

Applications 2,6-Dimethyl-d6-nitrobenzene (CAS# 285138-83-2) is a useful isotopically labeled research compound.

Applications Phosacetim-d8 is labelled Phosacetim (P353605), a toxic organophosphate compound which acts as an acetylcholinesterase inhibitor and is used as a rodenticide. References Rennison, B.: Pest. Sci., 8, 405 (1977); Ming, S., et al.: J. Anal. Toxicol., 12, 287 (1988)

Applications N-Acetyl-S-phenyl-d5-DL-cysteine is the deuterium labelled form of N-Acetyl-S-phenyl-DL-cysteine, which is used as a reactant in the preparation of potent HIV-1 protease inhibitors that use D-amino acids as P2/P3 ligands. References Jungheim, L., et al.: J. Med. Chem., 39, 96 (1996);

1,25-Dihydroxyvitamin D3-26,23-lactone is an analog of vitamin D3. It is a nucleophilic agent that can form covalent bonds with the side chain of amino acids in proteins. This analog has been shown to inhibit protein synthesis and induce apoptosis in prostate cancer cells by allylation and cleavage reactions. 1,25-Dihydroxyvitamin D3-26,23-lactone also inhibits cholesterol synthesis and collagen production. Thus, it may be used as a therapeutic agent for the treatment of prostate cancer.

Diethylstilbestrol-d8 is a synthetic estrogen that is used as an analytical standard for the detection of 17β-estradiol and estrone. Diethylstilbestrol-d8 has been used to monitor the synthesis of estrogens in human tissues and to measure the effects of estrogen on target cells. It has been shown that this compound binds to the estrogen receptor, which mediates its effects in a similar manner as natural estrogens. Diethylstilbestrol-d8 is also used to determine if the estrogen receptors are present in a sample. This can be done by measuring the response of cells to diethylstilbestrol-d8 or by measuring its binding to any receptor sites in a sample. Diethylstilbestrol-d8 has also been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

Applications Octadecanoic-17,17,18,18,18-d5 Acid (CAS# 211443-83-3) is a useful isotopically labeled research compound.

Applications n-Propyl-1,1-d2 Alcohol (CAS# 40422-04-6) is a useful isotopically labeled research compound.