Deuterated Compounds

Applications O-Benzyl-S-(methyl-d3)-3-thioacetaminophen is a useful synthetic intermediate for organic reactions.

Applications 1-Bromopropane-1,1-d2 (CAS# 40422-05-7) is a useful isotopically labeled research compound.

Applications Sodium 2-Methylpropionate-1-13C (CAS# 71105-51-6) is a useful isotopically labeled research compound.

Applications Methylcyclohexane-d11 (ring-d11) (CAS# 352431-19-7) is a useful isotopically labeled research compound.

Applications Abiraterone Ethyl Ether-d5 is the labeled analogue of Abiraterone Ethyl Ether (A108525), an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer. References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)

Applications A labelled form of Spiromesifen (S683505), which is a useful insecticide and miticide in plant breeding. Also useful in cannabis testing kits as a component of pesticide mixes (P698240). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Amino-4,6-dichloropyrimidine-13C2 (cas# 1346605-11-5) is a compound useful in organic synthesis.

Applications cis-8,11,14-Eicosatrienoic Acid Ethyl Ester-d5 is the isotope labelled analog of cis-8,11,14-Eicosatrienoic Acid Ethyl Ester (E477920); the ethyl ester derivative of cis-8,11,14-Eicosatrienoic Acid (E477930) which is a fatty acid with selective tumoricidal activity. References Das, U., et al.: Cancer Lett., 56, 235 (1991); Rudra, P., et al.: Anticancer Res., 21, 29 (2001); Menendez, J., et al.: Breast Cancer Res. Treat., 72, 203 (2002)

Applications Octanoic-8,8,8-d3 Acid (CAS# 156779-05-4) is a useful isotopically labeled research compound.

Halobetasol propionate-d3 is a biocompatible polymer that binds to the effector proteins of the inflammatory response. It is used in the treatment of inflammatory bowel disease, psoriasis, and other skin diseases. Halobetasol propionate-d3 has been shown to be effective against plaque and cutaneous lesions in patients with psoriasis. This drug also inhibits the production of proinflammatory cytokines (IL-1β, IL-6, IL-8) and chemokines (MCP-1) by monocytes. The drug has been shown to be effective against autoimmune diseases due to its ability to inhibit TNFα production from macrophages. Halobetasol propionate-d3 is compatible with blood group A, B, and AB.

Applications Glyceryl Trihexadecanoate-13C2 [1,3-Di(hexadecanoate-1-13C)] (CAS# 339080-65-8) is a useful isotopically labeled research compound.

Applications o-Anisidine is a highly toxic environmental pollutant and digestive system carcinogen. It is also a toxin that has been identified to be present in cigarettes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Coggins, C.R.E. et al.: Inhal. Toxicol., 23, 41 (2011); Dracinska, H. et al.: Neuroendorinol. Lett., 27, 9 (2006); Naiman, K. et al.: Neuroendocrinol. Lett., 31, 36 (2010);

22-Fluorovitamin D3 is a synthetic analog of vitamin D3, which is derived from chemical synthesis involving fluorination at the C-22 position. This modification results in a compound that mimics the structure and activity of naturally occurring vitamin D3 but with altered pharmacokinetics and metabolic stability. The fluorine atom, due to its size and electronegativity, influences the binding affinity and activity of the compound at vitamin D receptors. The primary mode of action of 22-Fluorovitamin D3 involves binding to the vitamin D receptor (VDR), similar to native vitamin D3. This binding initiates a cascade of genomic events leading to the regulation of various genes involved in calcium and phosphate homeostasis, as well as immune and cellular differentiation processes. The use of 22-Fluorovitamin D3 is predominantly in scientific research settings. Researchers utilize it to study the metabolism and biological effects of vitamin D, along with its role in diseases. Its altered stability makes it a valuable tool for probing the mechanisms of vitamin D-related metabolic pathways in both in vitro and in vivo models, providing insights into its potential therapeutic applications.

Please enquire for more information about 9-Ethyl-d5-adenine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 3-Chlorobenzoic-d4 Acid (CAS# 2098655-72-0) is a useful isotopically labeled research compound. The compound can be used to prepare isotopically enriched analogs for treating and preventing thrombosis. References Pandey, A., et.al., PCT Int. Appl., 51,(2017);

Applications A labelled acetylene glycol derivative. It is used in water-based coatings and has both antifoaming and surfactant properties. It is highly toxic and have been found in acrylic adhesives used for food packaging multilayers manufacturing. References Schwartz, J. et al.: J. Coat. Tecnhol., 67, 21 (1995); Chinoy, N.F. et al.: Polym. Paint Colour J., 175, 438 (1985);

Applications Dodecane-d26, is the labeled analogue of Dodecane (D494625), which is used in the synthesis of triblock polymers that deliver nanoparticles to the oil/water interface and degrade non-tocxc non-aqueous liquids. References Saleh, N. et al.: Nano. Lett., 2489, 5 (2005); Scarso, A. et al.: J. Am. Chem. Soc., 126, 13512 (2004);

Applications Octahydro-1H-pyrrolo[3,4-b]pyridine-d2 Di-trifluoroacetate is an intermediate in the synthesis ofhybrid antibacterial agents that exhibits inhibitory activities towards DNA Polymerase-Topoisomerase. References Zhi, C.X., et al.: J. Med. Chem., 49, 1455 (2006);

Applications 2,3-Butane-1,1,1,4,4,4-d6-diol (CAS# 344750-80-7) is a useful isotopically labeled research compound.

Applications Carbamazepine-D10 is used to study occurrence of emerging trace organic chemicals in wastewater effluents in Saudi Arabia. References Alidina, M., et al.: Sci. Total Environ., 478, 152 (2014);

Applications 3-(Trimethylsilyl)propionic Acid-d4 Sodium Salt (cas# 24493-21-8) is a compound useful in organic synthesis. References Tynkkynen, T. et al.; Anal. Chim. Acta 648, 105 (2009)

Applications A labelled metabolite of Di-n-pentyl phthalate (DPP), used mainly as a plasticizer in nitrocellulose. References Schmid, P., et al.: Xenobiotica, 1985, 15, 251 (1985), Nativelle, C., et al.: Food Chem. Toxicol., 37, 905 (1999), Howdeshell, K., et al.: Toxicol. Sci., 105, 153 (2008),

Applications Acetophenone-13C6 is an intermediate in synthesizing Ibuprofen-13C6 (I140003), a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)

Applications Indole-2,4,5,6,7-d5 is the intermediate in the synthesis of Indole-d6 (I577322), which is a labelled Indole (I577320). Can be used in perfumes and in the synthesis of tryptophan. References Kawano, T. et al.: Gen. Hypo. 60, 664 (2003);

Applications N-Nitro-S-methylisothiourea-13C is an intermediate used in the synthesis of Clothianidin-d3, 13C1 (C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops. References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications Chlorobenzene-4-d1 (CAS# 13122-34-4) is a useful isotopically labeled research compound.

Applications N,N-Dimethylacetamide (D9, 99%) (cas# 16727-10-9) is a useful research chemical.

Applications Labelled Propafenone (P757500) impurity. References Kitagawa, S., et al.: Biol. Pharm. Bull., 29, 1 (2006), Boccard, J., et al.: Eur. J. Pharm. Sci., 36, 254 (2009)

Applications Sulfoxaflor-d3 is the isotope analog of Sulfoxaflor. Sulfoxaflor, is a new insecticide which acts as an insect neurotoxin, and is the only member of class of chemicals called the sulfoximines which act on the central nervous system of insects with much lower toxicity to mammals. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anon, IP.com J., 12, 19 (2011)

Applications Anisole-2,3,4,5,6-d5 (CAS# 50629-14-6) is a useful isotopically labeled research compound.

Applications Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.

Applications 1-(4-Amino-3,5-dichlorophenyl)-2-((4-hydroxycyclohexyl-D10)amino)ethanone is an intermediate in the synthesis of Clencyclohexerol-d10 (C572502), which is a labelled analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals. References Maistro, S., et al.: Lancet, 346, 180 (1995); Vanoosthuyze, K., et al.: J. Agric. Food Chem., 45, 3129 (1997); Fiori, M., et al.: Anal. Chim. Acta, 529, 207 (2005); Salquebre, G., et al.: J. Anal. Toxicol., 31, 114 (2007);

Applications 1,5-Diaminonaphthalene (D416415). Aromatic amines likely to have high carcinogenic potency. QSARs of aromatic amines. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Franke, R., et al.: Carcinogenesis, 22, 1561 (2001), Benigni, R., et al.: Chem. Rev., 105, 1767 (2005), Benigni, R., et al.: Environ. Mol. Mutagen., 50, 152 (2009),

Applications 1,3-Propane-2,2-d2-diamine 2HCl (CAS# 352438-79-0) is a useful isotopically labeled research compound.

Applications 1-Bromoundecane-d23 (CAS# 349553-92-0) is a useful isotopically labeled research compound.

Applications (2,4-Dichlorophenoxy-d3)acetic-d2 Acid (CAS# 352438-69-8) is a useful isotopically labeled research compound.

Please enquire for more information about (2S,5S)-5-Hydroxy-1,2-piperidinedicarboxylic acid2-methyl 1-benzylester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Isotope labelled analogue of D-Allose (A548006) is a rare naturally occurring monosaccharide, known to exert anti-proliferative effects on cancer cells. References Jeong, R.U., et al.: Anal. Bioanal. Chem., 401, 689 (2011); Yamada, K., et al.: Nut. Res., 32, 116 (2012);

Applications rac-threo-Methyl-13C, d3-phenidate Hydrochloride is the labeled analog of rac-threo-Methylphenidate Hydrochloride (M325671), which has shown that the pharmacological activity resides predominantly in the d-threo enantiomer. References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961); Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981); Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993); Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993)

Applications Isotope labelled D-Fructose (F792500), a monosaccharide that naturally occurs in large number of fruits and plants. References Shum, M., et al.: Am. J. Physiol., 304, 197 (2013); Zeng, S.S., et al.: J. Pharma. Biomed. Anal., 76, 87 (2013);

Applications 8-Bromo-7-ethyl-3,7-dihydro-3-methyl-1H-purine-2,6-dione-d5, is the labeled analogue of (B684895), which is a substituted derivative of Xanthine (X499950). References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)

Applications 4-n-Pentyl-d11-phenol (CAS# 1219805-30-7) is a useful isotopically labeled research compound.

Applications Methyl 5-Hydroxy-2-benzimidazolecarbamate-d3, is a labeled analogue of Methyl 5-Hydroxy-2-benzimidazolecarbamate (M312585), which is a derivative of Carbendazim (C175900). References Zeng, Z., et al.: J. Agric. Food Chem., 44, 3374 (1996), Lewis, D., et al.: Xenobiotica, 28, 235 (1998), Hodgson, E., et al.: J. Biochem. Mol. Toxicol., 21, 182 (2007),

Applications (3,4-Dinitrophenyl)(phenyl-d5)methanone is an intermediate for the synthesis of Mebendazole-d8 (M200502), which is labelled Mebendazole (M200500). Anthelmintic (Nematodes). References Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 16, 291 (1987)

Please enquire for more information about 4-Methoxy-d3-benzoicacid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications DL-2-aminobutyric Acid-D5 is an intermediate used in the synthesis of Methyl Ergonovine-d5 Maleate Salt (M304602), which is a labeled metabolite of Methysergide. Semisynthetic ergot alkaloid. Oxytocic. References Mueller, L., et al.: Headache, 37, 437 (1997), de Groot, A.N., et al.: Drugs, 56, 523 (1998)

Applications Quinaldic-d6 Acid (CAS# 1219802-18-2) is a useful isotopically labeled research compound.

Applications A labelled metabolite of the antihypertensive agent, Labetalol (L096500). Ractopamine impurity. References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),

23,23-Difluoro-25-Hydroxyvitamin D3 is a metabolite of 25-hydroxyvitamin D3, which is a biologically active form of vitamin D. 23,23-Difluoro-25-Hydroxyvitamin D3 has been shown to have suppressive effects on intestinal calcium transport and mineralization. This metabolite can be used as an alternative to 1,25-dihydroxyvitamin D3 in the treatment of rickets.

Applications 1,2,4,5-Benzenetetracarboxylic Acid-d6 (CAS# 344298-79-9) is a useful isotopically labeled research compound.

Applications 2-(Formylamino)-3-hydroxy-2-propenoic-13C2 Acid Ethyl Ester (cas# 1391062-48-8) is a compound useful in organic synthesis.

Stability Volatile Applications Assignments of far-IR (FIR) laser lines have been found for optically pumped Methanol-13C. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Moraes, J.C.S., et. al.: J. Mol. Spec., 177, 302 (1996)

Stability Hygroscopic Applications Labelled Homarine (H458500). Quaternary ammonium base occurring in tissues of marine animals. References Stein, W., et al.: J. Biol. Chem., 211, 915 (1954), Bystedt, J., et al.: J. Sci. Food Agric., 10, 301 (1959),

Applications 6-Amino-3-methyluracil-d3 (cas# 1246820-43-8) is a compound useful in organic synthesis. References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983)

Applications Tri-p-tolylamine-d21 (CAS# 201944-90-3) is a useful isotopically labeled research compound.

Applications 2-Phenyl-d5-ethyl Isothiocyanate (CAS# 912627-98-6) is a useful isotopically labeled research compound.

Applications Isotope labelled 1-Bromobutane (B681830) is used in the synthesis of specifically-deuterated procaine and tetracaine. References Boulanger, Y., et al.: J. Labelled Comp. Radiopharm., 18, 1197 (1981),

Applications 6-Nitrodopamine-d4 is the labeled analogue of 6-Nitrodopamine(N493722), a reagent used in the detection of cancer biomarker prostate specific antigen (PSA). References Li, H., et. al.: Biosensors Bioelectronics, 26, 3044 (2011)

Applications 1,3-Diaminopropane-d6 is the isotope labelled analog of 1,3-Diaminopropane. 1,3-Diaminopropane is a common chemical reagent, used in the synthesis of 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors applied in the treatment of Alzheimer’s disease. Also used in the synthesis of thrombosis inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Spilovska, K. et al.: Molecules, 18, 2397 (2013); Smith, S. et al.: Blood, 120, 5103 (2012);

Stability Volatile Applications 1-Bromobutane-d3 is used in the synthesis of specifically-deuterated procaine and tetracaine. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Boulanger, Y., et al.: J. Labelled Comp. Radiopharm., 18, 1197 (1981),

Applications An intermediate of Rosuvastatin (R700502). Rosuvastatin is a selective, competitive HMG-CoA reductase inhibitor. References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006),

Applications 2,​4,​6-​Trifluorobenzenemethanamine-d4,15N Deuterium Chloride is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications Bromocyclopropane-d5 is labelled bromocyclopropane (B682760) which is used as a reagent to synthesize substituted (carboxycyclopropyl)glycines as potent and selective group II metabotropic glutamate receptor antagonists. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ornstein, P., et al.: J. Med. Chem., 41, 358 (1998)