Deuterated Compounds

Applications Solifenacin-d7 hydrochloride is deuterium labelled Solifenacin hydrochloride (S676700), which is a Muscarinic M3 receptor antagoinst and used to treat urinary incontinence. References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002), Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004), Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004), Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005), Habb, F., et al.: Eur. Urol. 47, 376 (2005), Payne, C.K., et al.: Drugs, 66, 175 (2006),

Applications 2-Naphthalenecarboxylic Acid-13C6 (cas# 1346602-42-3) is a compound useful in organic synthesis.

Applications Nicotinic Acid Riboside-d4 Methyl Ester Triflate O-Acetate is an intermediate used in the synthesis of Nicotinic Acid Riboside-d4 Methyl Ester Triflate (N429407), which is the labelled analogue of an effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells. References Belenky, P. et al.; J. Biol. Chem. 284, 158 (2009); Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);

Applications L-Methionine Sulfoxide 13C1 is a labelled analogue of L-Methionine Sulfoxide ( M260450). L-Methionine Sulfoxide ( M260450) an intermediate in the synthesis of the acyclic amino carboxylic acid L-Methionine sulfoximine. References Lee, B., et al.: J. Biol. Chem., 283, 28361 (2008), Nordqvist, A., et al.: Bioorg. Med. Chem., 16, 5501 (2008);Balog, E., et al.: Biochem., 48, 3005 (2009);

Applications 9-Fluorenone-D8 is a labelled analogue of 9-Fluorenone (F462780). 9-Fluorenone is a polycyclic aromatic ketone that has photosensitizing properties and also has the ability to undergo electrochemical polymerization. 9-Fluorenone is used in industry as an initiator in visible-light cured resin systems. 9-Fluorenone has potentially toxic effects on humans, as exposure can cause DNA mutations. References Cihaner, A., et al.: J. Elec. Chem., 568, 151 (2004); Li, Y., et al.: J. Biomed. Mater. Res. Part B-A, 84, 58 (2008); Okamoto, H., et al.: Org. Lett., 13, 2758 (2011)

Applications Hexazinone-d6 (dimethyl-d6-amino) (CAS# 1219804-22-4) is a useful isotopically labeled research compound.

Applications 2-​Pyrimidin-​4,​6-​d3-​amine is a byproduct in the synthesis of 2-Chloropyrimidine-d3 (C380852), which was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state. References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)

Applications Bis(1-ethylpentyl) Phthalate-d4, is the labeled analogue of Bis(1-ethylpentyl) Phthalate (B433990), one of the phthalate esters, which are ubiquitous environmental contaminants that interact with peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors. It is used as a plasticizer to impart softness and flexibility to PVC products. References Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);

Applications 1-Bromo-3,4-difluorobenzene-d3 (CAS# 1219799-14-0) is a useful isotopically labeled research compound.

Applications Benzoic Acid (Carboxyl-13c, 99%) (cas# 3880-99-7) is a useful research chemical.

Applications Isotope labelled 1,4-Dichlorobenzene is labelled 1,4-Dichlorobenzene (D431875), a versatile building block and a small bioactive molecule, used in various organic synthesis. It is also used as disinfectant, deodorant, and pesticide. References Fahey, D. R., et al.: Macromolecules, 24 (15), 4242 (1991); Rossberg, M., et al.: Ullmann's Encyclopedia of Industrial Chemistry, (2006);

Applications 4-[(Tetrahydro-2H-pyran-2-yl)oxy]-2-butyn-1-ol-1,2,3,4-13C4 is an intermediate in the synthesis of N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 (A173713). N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 is labelled N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (A173710), which is a metabolite of butadiene. References Heavner, D., et al.: J. Pharm. Biomed. Anal., 40, 928 (2006); Carmella, S., et al.: Chem. Res. Toxicol., 22, 734 (2009)

Applications 5-(N,N-Dimethyl)-amiloride-d6 Hydrochloride is an isotopic analog of 5-(N,N-Dimethyl)-amiloride Hydrochloride (D470570), which has been used to investigate biochemical processes related to the circadian clock in mouse and human cell lines. It can also inhibit sodium-hydrogen exchangers (NHE). NHEs regulate sodium and pH in various tissues. References Isojima, Y., et al.: Proc. Natl. Acad. Sci. USA 106, 15744 (2009); Masereel, B., et al.: Eur J Med Chem 38, 547 (2003)

Applications 4-(Iodoacetylamino)phenol-d4 is an isotope labeled analog of 4-(Iodoacetylamino)phenol (I535250), which is an analytical reagent.

Applications Trilithium UDP-glucuronic Acid-3C1, 5N2 is an isotope labelled analog of Trisodium UDP-glucuronic Acid (T886285). Trisodium UDP-glucuronic Acid is a reactant used in the enzymatic preparation of β-glucuronides. References Stevenson, D.E., et. al.: Collect Czech. Chem. C., 65, 117 (2000); Robotham, S.A., Brodbelt, J.S.: Biochem. Pharmacol., 82, 1764 (2011); Kren, V., et. al.: Drug Metab. Dispos., 28, 1513 (2000)

Applications Hexanedioyl-d8 Chloride (CAS# 284487-62-3) is a useful isotopically labeled research compound.

Applications Deoxycholic Acid-24-13C (CAS# 52886-37-0) is a useful isotopically labeled research compound.

Applications Palmitoyl-16,16,16-d3-L-carnitine Hydrochloride is the isotope labelled analog of Palmitoyl-L-carnitine Hydrochloride (P155050); a long-chain fatty ester of carnitine which is accumulated and released into the circulation in fatty-acid oxidation defects. References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications Bromocyclohexane-d11 is used in the synthetic preparation and regioselective bromination of sp3 C-H bonds by organophotoredox catalysis. References Kee, C.W., et al.: Asian. J. Org. Chem., 3, 536 (2014);

Applications Used for preparation of phthalide derivatives for treatment of diabetes.

Methylphenidate-D9 is a synthetic version of methylphenidate that has been chemically modified to increase its stability and bioavailability. Methylphenidate-D9 is used in the treatment of ADHD and narcolepsy, as well as for the management of obesity. Its safety profile has been studied in both humans and animals, with no adverse effects seen at doses up to 1000 mg/kg. Methylphenidate-D9 can be detected in plasma concentrations following oral administration, as well as in urine samples after excretion. It can be detected in wastewater treatment plants via liquid chromatography.

Applications Cholesterol-3,4-13C2 (CAS# 78887-48-6) is a useful isotopically labeled research compound.

Applications 1,10-Phenanthroline-d8 (CAS# 90412-47-8) is a useful isotopically labeled research compound.

Applications N-Benzyldiethylamine-d4 is an intermediate in the synthesis of labelled N-Nitrosodiethylamine (N525465), a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver. References Forbush, B., et al.: J. Bio. Chem., 263, 7979 (1988);

Applications Ethyl 3-Methyl-2-butenoate-d6 (cas# 53439-15-9) is a compound useful in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Hexadecanoic-4,4-d2 Acid (CAS# 30719-28-9) is a useful isotopically labeled research compound.

Applications Norfloxacin-d5 is deuterium labeled Norfloxacin (N681000), a synthetic fluoroquinolone and an antibacterial agent. Norfloxacin can be used to treat urinary tract infections. References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980), Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981), Holmes, B., et al.: Drugs, 30, 482 (1985),

Applications 1,10-Decanedioic-d16 Acid (CAS# 73351-71-0) is a useful isotopically labelled compound for studying saturated fatty acids. References Yamada, T., et al.: Adv. Synth. Catal., 358, 3277 (2016)

Applications 1-[5-Chloro-2-(2,4-dichlorophenoxy)phenylethanone]-d3 (cas# 1189886-69-8) is a compound useful in organic synthesis.

Applications Ethanolamine is used in the preparation of various pharmaceutical compounds and inhibitors. Substituted carboxamides are synthesized using Ethanolamine that show potent antitumor activity. Also used in the synthesis of aminoquinolones which display anti-plasmodial activity. References Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000)

Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N-(methyl-d3)-O-ethylcarbamate (cas# 1189709-65-6) is a compound useful in organic synthesis.

Applications 5-Oxo-DL-proline-d5 is a labelled cyclized derivative of L-Glutamic Acid (G596960). The pyroglutamate core has potential application for synthesis of novel anti-bacterials. References Mischo A. et al.: ChemBioChem., 13, 1421 (2012); Angelov P. et al.: Org. Biomol. Chem.: 10, 3472 (2012);

Applications 4-Bromophenyl Phenyl-d5 Ether (CAS# 93951-83-8) is a useful isotopically labeled research compound.

Applications N-Boc-(p-Aminobenzoyl)-L-glutamic Acid Dimethyl Ester-13C5 is an intermediate used in the synthesis of Folic Acid-13C5 (F680303), which is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications 1-Bromopropane-3,3,3-d3 is labelled 1-Bromopropane (B687135) which is used as a solvent and for the cleaning of metal surfaces, removal of soldering residues from electronic circuit boards. It is anticipated to be human carcinogen. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lingyo Zh., et al.: Toxicology, 304, 76 (2013); Samukawa, M. et al.: Archives Internal Med., 172(16), 1257 (2012);

Please enquire for more information about 4-Hydroxybenzaldehyde-2,3,5,6-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications N,N-Diisopropyl-3-(2-methoxy-5-methyl-phenyl)-3-phenylpropylamine-d14 (cas# 1795031-80-9) is a compound useful in organic synthesis.

Applications Ethylenediaminetetraacetic-d12 Acid (CAS# 203806-08-0) is a useful isotopically labeled research compound.

Applications Methyl Benzoate-d8 (CAS# 91929-46-3) is a useful isotopically labeled research compound.

Applications Glyceryl Tri(pentadecanoate-d29) (CAS# 352431-43-7) is a useful isotopically labeled research compound.

Applications Isotope labelled Propyl Paraben Sulfate (P838355) is the sulfate conjugate of Propyl Paraben (P838285), an antimicrobial agent used in cosmetic products. References Kim, D.H., et al.: Biol. Pharma. Bull., 17, 1326 (1994);

Applications A labelled metabolite of Propafenone (P757500).

Applications N-(Benzoyl)piperazine-2,2,3,3,5,5,6,6-d8 (CAS# 1219805-49-8) is a useful isotopically labeled research compound.

Applications 3,3’-((2-Hydroxypropane-1,3-diyl)bis(oxy))bis(2-(3-ethoxy-3-oxopropanoyl)phenolate) Disodium Salt-d5 is an intermediate used in the synthesis of Cromolyn-d5 Disodium Salt (C815002), which is a chromone complex which blocks mast cell degranulation. References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)

Applications 2-Bromofluorobenzene-d4 (CAS# 50592-35-3) is a useful isotopically labeled research compound.

Applications 3-Pentyl-2,2,3,4,4-d5 Alcohol (CAS# 144032-75-7) is a useful isotopically labeled research compound.

Applications Benzene-1,2,3-d3 (CAS# 19467-27-7) is a useful isotopically labeled research compound.

Applications Labelled Butylparaben. An antimicrobial agent used in cosmetic products. References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),

Applications 5-Bromo-6-chlorobenzene-1,2,3,4-d4 is the isotope labelled compound of (B682312) which is a reagent in the preparation of arylpiperidines and aryltetrahydropyridines as 5-HT2C agonists. References Conway, R.J., et al.: Bioorg. Med. Chem. Lett., 22, 2560 (2012)

Applications The formation of p-Cresol-(methyl-13C) via phenol methylation at higher temperature from the deactivation of basic catalyst. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Borodina, I. B., et al.: Russ. J. Phys. Chem., 80, 892-898 (2006)

Stability Hygroscopic Applications Labelled O,O-Diethyl Thiophosphate (D445120). Used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor. References Sussman, J., et al.: Science, 253, 872 (1991), Mallender, W., et al.: J. Biol. Chem 1999, 274, 8491,

Applications N-Hexanoylglycine-2,2-d2 (CAS# 1256842-52-0) is a useful isotopically labeled research compound.

Applications 1-Nitronaphthalene-d7 is a useful labeled compound in the regioselective preparation of naphtho[1,8-bc]pyridines. References Yan, K., et al.: Advanced Synthesis & Catalysis, 361, 1570 (2019)

Applications L-Homocitrulline-2,6,6-d3 is a labeled compound of L-Homocitrulline (H590900) which is an amino acid present in milk products. References Evered, D. & Vadgama, J.: Br. J. Nutr., 49, 35 (1983); Paik, W., et al.: Int. J. Biochem., 8, 317 (1977)

Applications Labelled Sulfanilic acid (S689095). Sulfanilic acid is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial. References Collins, T., et al.: Food Chem. Toxic., 28, 821 (1990), Levine, W., et al.: Drug Metab. Rev., 23, 235 (1991), Sasaki, Y., et al.: Mutat. .Res., 519, 103 (2002),

Applications 1,2-Bis(4-hydroxyphenyl)-2-hydroxypropane-d3 is labelled 1,2-Bis(4-hydroxyphenyl)-2-hydroxypropane (B447367) which is a metabolite of bisphenol A (B519495). It works as an endocrine disruptor. References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993), Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Kitamura, S., et al.: Toxicol. Sci., 84, 249 (2005)

Applications A labelled metabolite of Catecholamines. References Kopin, I.J., et al.: J. Biol. Chem., 236, 2109 (1961), Short, F.W., et al.: J. Med. Pharm. Chem., 5, 642 (1962)

Applications Isotope Labelled 2,4,6-Trichloroanisole (T774085), which is considered the main compound responsible for the cork taint, a wine flavor defect usually perceived as a moldy off-flavor. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Chatonnet P. et al.: J Agric Food Chem. 2004 Mar 10;52(5):1255-62. 2. Cserjesi, A. et al.: Can J Microbiol. 1972 Jan;18(1):45-9.

Applications 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine-d4 is labelled 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine (D448690) which is a derivative of 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine. 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine is used to prepare benzanilide derivatives for use as anticancer agents.

Applications 4-Chlorotoluene-d7 (CAS# 84344-06-9) is a useful isotopically labeled research compound.

Applications 4-Chloro-6-nitrosoresorcinol-13C6 (cas# 953390-33-5) is a compound useful in organic synthesis.

Applications rac Fosfomycin-D5 (Major) Benzylamine Salt is the deuterium labelled analogue of Fosfomycin antibiotic. Related to Fosfomycin Disodium Salt (F727500), rac Fosfomycin-13C3 Benzylamine Salt (F727502), Fosfomycin Tromethamine (F727505), and Fosfomycin Calcium (F727508). References Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981); Michalopoulos, A. et al.: Int. J. Infect. Dis., 15, e732 (2011); Matsumoto, T. et al.: J. Infection. Chemother., 17, 80 (2011); Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013);

Rac 4-Hydroxy-3-methoxyphenylethylene Glycol-d3 is a glyoxylate that is used for the synthesis of epinephrine and norepinephrine. Rac 4-Hydroxy-3-methoxyphenylethylene Glycol-d3 can be prepared by the alkylation of racemic catechol with glyoxylic acid. Rac 4-Hydroxy-3-methoxyphenylethylene Glycol-d3 can be quantified by gas chromatography, which separates Rac 4-Hydroxy-3-methoxyphenylethylene Glycol from other racemic compounds. Rac 4-Hydroxy-3-methoxyphenylethylene Glycol can also be synthesized from mandelic acid by hydrogenolysis using sodium borohydride and diborane in methanol or ethanol. Rac 4-Hydroxy--phenylethylene

Applications Heptyl 5-Methyl-2-hexyl Phthalate-d4, is the labeled analogue of Heptyl 5-Methyl-2-hexyl Phthalate, a phthalate ester used as plasticizers and additives. References Peterson, J.C., et al.: Int. J. Envrion. Anal. Chem., 18, 237 (1984);

Applications A labelled metabolite of Dichloropropanols. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Velisek, J., et al.: J. Agric. Food Chem., 28, 1142 (1980), Johnson, J., et al.: Anal. Chem., 62, 2162 (1990),

Applications 4-Ethylaniline-d11 (CAS# 1219802-96-6) is a useful isotopically labeled research compound.

Applications 2-Nitrobenzonitrile-d4 (CAS# 1219795-50-2) is a useful isotopically labeled research compound.

Applications Labelled Diflufenican (D445640). (Pre and post emergence foliar absorbed herbicide for winter weed control in cereal crops; carotenoid biosynthesis inhibitor. References Conte, E., et al.: J. Agric. Food Chem., 46, 4766 (1998),