Deuterated Compounds

Applications 4-Hydroxypiperidine-D4 is an isotope labelled form of 4-Hydroxypiperidine (H950845), a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists. References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999);

Applications 1,2-Cyclohexane-d10-diamine (cis/trans mixture) (CAS# 2120097-66-5) is a useful isotopically labeled research compound.

Applications Isopropanol (2-13c, 99%) (cas# 21388-65-8) is a useful research chemical.

Applications Labelled analog of a restricted use pesticide. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bradford, D., et al.: Environ. Sci. Technol., 44, 4609 (2010), Trtic-Petrovic, T., et al.: Anal. Bioanal. Chem., 397, 2233 (2010), Stewart, C., et al.: Weed Biol. Man., 10, 40 (2010),

Applications 2-Chloro-N,N-diethylethylamine-d10 Hydrochloride is the isotope labelled analog of 2-Chloro-N,N-diethylethylamine Hydrochloride. 2-Chloro-N,N-diethylethylamine Hydrochloride used in the preparation of nonsteroidal antiestrogens. As well, it is used in the synthesis of novel cyanopyridine derivatives used in the design of antibacterial drugs. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Jones, C. et al.: J. Med. Chem., 27, 1057 (1984); Bogdanowicz, A. et al.: J. Hetero. Chem., 50, 544 (2013);

Applications n-Hexadecyl-d33-amine (CAS# 1191245-82-5) is a useful isotopically labeled research compound.

Applications Isotope labelled 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, the novel raw material for deodorants application and is widely used as a cosmetic emollient. 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol reliably inhibits the odor-causing bacteria, yeast and fungi on the skin. References Nagao, S.: Frag. J., 34, 39 (2006); Lawan, K. et al.: J. Health Sci., 23, 1 (2009); Leschke, M.: SOFW J., 136, 10 (2010);

Applications Sodium Hexadecanoate-16,16,16-d3 (CAS# 347841-37-6) is a useful isotopically labeled research compound.

Applications 2,2'-Binaphthyl-d14 (CAS# 210487-05-1) is a useful isotopically labeled research compound.

Applications 8,9-Dihydro-2-methyl-9-(4-methylphenyl)-8-oxo-7H-purine-6-carboxamide-d7 is a compound useful in organic synthesis.

Applications 1-Bromo-3,5-difluorobenzene-d3 (CAS# 1219798-73-8) is a useful isotopically labeled research compound.

Applications Methyl-[4-(dimethylsulfonylamino)phenylethyl]-[4-(dimethylsulfonylaminophenoxyethyl-d4)amine (cas# 1397192-78-7) is a compound useful in organic synthesis.

Applications Bromoethane-2-d1 (CAS# 23705-67-1) is a useful isotopically labeled research compound.

Applications 3,5-Dichlorobenzoic-d3 Acid (CAS# 1219803-99-2) is a useful isotopically labeled research compound.

Applications Tri(n-octyl-1,1-d2)amine (CAS# 1219798-90-9) is a useful isotopically labeled research compound.

Applications 2-(Benzoyloxy)ethyl-d4 Benzoate is an intermediate in the synthesis of Acyclovir-d4 (A192402), an orally active acyclic labelled nucleoside with inhibitory activity towards several herpes viruses. Antiviral. References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)

Please enquire for more information about Clobetasone 17-Butyrate-d7 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Isotope labelled N-Iodoacetyltyramine (I685880) is used in iodine-125 labelling of various molecules for chemical analysis. References Lin, C. et al.: Anal. Biochem., 179, 389 (1989);

Applications A labelled impurity of the anti-viral Lamivudine (L172500). References Dwyer, O.: Synlett, 11, 1163 (1995);

Applications Naphthalene-d8, is the labeled analogue of Naphthalene, a polycyclic aromatic hydrocarbons as micropollutants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Di Toro, D., et al.: Environ. Toxicol. Chem., 19, 1971 (2000), Vines, C., et al.: Aquat. Toxicol., 51, 225 (2000), Incardona, J., et al.: Toxicol. Appl. Pharmacol., 196, 191 (2004), Junghans, M., et al.: Aquat. Toxicol., 76, 93 (2006),

Please enquire for more information about Linoleic acid-13C18 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 3,5-Dimethyl-d6-cyclohexanone-3,4,4,5-d4 (mixture of isomers) (CAS# 1219804-55-3) is a useful isotopically labeled research compound.

Stability Hygroscopic Applications Labelled nucleotide. References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010), Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010),

Applications An intermediate in the production of labelled Enrofloxacin. References Chao, Q., et al.: J. Med. Chem., 52, 7808 (2009), Bebbington, D., et al.: Bioorg. Med. Chem. Lett., 19, 3586 (2009),

Applications n-Hexyl 4-Hydroxybenzoate-2,3,5,6-d4 is the isotope labelled analog of n-Hexyl 4-Hydroxybenzoate; a phenolic acid alkyl ester/paraben that shows antimicrobial activity and antioxidant properties. References Merkl, R., et al.: Czech J. Food Sci., 28, 275 (2010)

Applications Potassium Dodecanoate-2,2-d2 (CAS# 82867-25-2) is a useful isotopically labeled research compound.

Adefovir-D4 is a prodrug that is metabolized by the liver to its active form, adefovir. Adefovir-D4 is used as a treatment for chronic hepatitis B virus (HBV) infection. It may be used in combination with pegylated interferon alfa-2a and ribavirin. Adefovir-D4 has been shown to inhibit the growth of renal epithelial cells and reduce the production of nephrotoxins. The pharmacokinetic profile of this drug has been studied in detail and it is known that it binds to proteins after intravenous administration, which causes an increase in its plasma concentration. This drug also has a chromatographic profile, which can be useful for measuring plasma concentrations in patients with renal impairment.

Applications Phenyltrimethyl-d9-ammonium Methane-d3-sulfonate is an intermediate in the synthesis of Oxycodone-d3 (O870603), a labelled Oxycodone (O870600), a controlled substance (opiate). Analgesic (narcotic). References Mendelson, J., et al.: Clin. Pharmacol. Ther., 60, 105 (1996); Fudala, P., et al.: N. Engl. J. Med., 349, 949 (2003); Alho, H., et al.: Drug Alcohol Depend., 88, 75 (2007)

Applications 4-Chlorobenzamide-2,3,5,6-d4 (CAS# 1219794-65-6) is a useful isotopically labeled research compound.

Sex pheromone inhibitor IPD1 is an antibody that inhibits the production of sex pheromones by Streptococcus faecalis. It is used to diagnose and treat allergic diseases, such as atopic dermatitis or bronchial asthma. This antibody binds to a protein called polypide, which is involved in the synthesis of sex pheromones, and inhibits its activity. It has been shown to inhibit the production of sex pheromones by Streptococcus faecalis when analyzed using an SDS-polyacrylamide gel electrophoresis method. Sex pheromone inhibitor IPD1 also binds to antibodies against streptococcus, acari, and other bacteria.

Applications Isotope Labelled Adipodinitrile is used in the preparation of alkyl/arylthiazolines in the efficient synthesis of bacillamide A. Also used in the preparation of arylketones via insertion of nitriles. References Fache, F. et al.: Synth. Comm., 42, 2098 (2012); Hsieh, J. et al.: Org. Lett., 14, 1282 (2012);

Applications Propio-d5-phenone (CAS# 342610-99-5) is a useful isotopically labeled research compound.

Applications L-(+)-Lactic Acid-13C3 Sodium Salt is the isotope labelled analog of L-(+)-Lactic Acid Sodium Salt. Sodium Salt of Lactic Acid (L113500). L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids. References Borsook, et al.: J. Biol. Chem., 102, 449 (1933); Brin, M., et al.: Ann. N.Y. Acad. Sci., 119, 851 (1965);

Applications Tryptamine-d5 is an isotope labelled form of Tryptamine (T894600). Tryptamine is a monoamine alkaloid found in plants. Tryptamine is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics. References Nichols, D. E., et al.: Curr. Top. Behav. Neurosci., 36, 1 (2018); Espinoza, S., et al.: Top. Med. Chem., 23, 175 (2017)

Applications Cyclopropyl Methyl Ketone-d8 (CAS# 1219799-33-3) is a useful isotopically labeled research compound.

Applications α,α-Dimethyl-1H-indole-2-acetonitrile-13C315N is an isotope labelled intermediate in the synthesis of serotonin-3 receptor antagonists. References Kato, M., et al.: Chem. Pharma. Bull., 42, 2556 (1994);

Applications Dibenzylamine-d10 is the isotope labelled analog of Dibenzylamine (D417505); a chemical contaminant in L-(+)-β-hydroxybutyrate that exhibits direct anticonvulsant actions in vivo. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Rho, J.M., et al.: Epilepsia, 43, 358 (2002)

Applications p-Xylene-alpha,alpha,alpha-d3 (CAS# 26204-18-2) is a useful isotopically labeled research compound.

Applications Isotope labelled 24 Bisphenol S (B519620) is a material used in thermal printing. 24 Bisphenol S is also used in the development of black leuco dyes. References Shima, H. et al.: J. Imag. Sci. Technol., 54, 020502 (2010)

Applications Hydrazinecarboxamide-13C Monohydrochloride is an intermediate used in the synthesis of 1-Amino Hydantoin-13C3 (A611092), which is a metabolite of Nitrofuran. Environmental contaminants; Food contaminants; Heat processing contaminants References Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006), Chu, P., et al.: J. Agric. Food Chem., 55, 2129 (2007),

Applications Ethyl 4-Isocyanatobenzoate-2,3,5,6-d4 (CAS# 1219802-91-1) is a useful isotopically labeled research compound.

Applications Labelled 2-Bromo-5-picoline (B685570). Used for preparation of [[(triazolylmethyl)pyridyl]phenyl]tetrazoles and related compounds as cardiovascular agents. References Behforouz, M., et al.: J. Med. Chem., 46, 5773 (2003), Behforouz, M., et al.: Bioorg. Med. Chem., 15, 495 (2007),

Applications Tri-iso-propyl-d21-phosphine Carbon Disulfide Complex (CAS# 1219798-41-0) is a useful isotopically labeled research compound.

Applications Bis(2,3-dibromopropyl) Phosphate-d10 is the isotope labelled analog of Bis(2,3-dibromopropyl) Phosphate. Bis(2,3-dibromopropyl) Phosphate is a derivative of Tris(2,3-dibromopropyl) Phosphate, a widely used flame retardant in plastic and textiles. References Elliott, W.C., et al.: Life. Sci., 7, 1107 (1983);

Applications 1,1-Dichloroethane (2,2,2-D3, 98%) (cas# 56912-77-7) is a useful research chemical.

Applications Phosphoric Acid-D4 Trifluoroboroane Deuterium Oxide is an intermediate in the synthesis of 3-Hydroxy Benzopyrene-d11 (H829402), which is a abelled metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer. References DiBiasio, K., et al.: Drug Metab. Dispos.,19, 227 (1991), Beach, J., et al.: J. Anal. Toxicol., 24, 670 (2000), Borman, S., et al.: Toxicol. Appl. Pharmacol., 167, 191 (2000), Tsai-Turton, M., et al.: Biol. Reprod., 77, 442 (2007),

Applications n-Propyl-d7-benzene (CAS# 65087-58-3) is a useful isotopically labeled research compound.

Applications 1-Naphthoic Acid-d7 (cas# 634179-80-9) is a compound useful in organic synthesis.

Applications 1-Nitropyrene-d9 is a labelled isotope of 1-Nitropyrene (N519950), which is the most abundant nitropolycylcic aromatic hydrocarbon found in exhaust from diesel engines with potent carcinogenic and mutagenic properties. It is also an intermediate in synthesizing 1-Aminopyrene-d9 (A629287), which is derived from Pyrene-d10 (P849002), which is labelled Pyrene. Occurs in coal tar. Also obtained by the destructive hydrogenation of hard coal. References Arce, R., et al.: J. Phys. Chem. A., 112, 10294 (2008); Winterstein, et al.: Z. Physiol. Chem., 230, 162 (1934);

Applications Benzoic Acid-13C6 (cas# 125945-98-4) is a compound useful in organic synthesis.

Applications MCPA Ethyl Ester-D3 is the deuterated form of MCPA Ethyl Ester (M199705), which is a derivative of MCPA, an herbicide. References Elliott, B., et al.: Mutagenesis, 20, 3 (2005), Pfleeger, T., et al.; Environmental Toxicology and Chemistry 30, 455 (2010)

Applications 2,5-Bis(Trifluoromethyl)nitrobenzene-13C6 is an intermediate in the synthesis of Dutasteride-13C6 (D735002), which is a labeled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia. References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),

Applications Pyrrolidine-2,2,5,5-d4 Hydrochloride is the salt, labeled analogue of Pyrrolidine (P997950), a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs). References Li, X. et al.: Mini-Rev. Med. Chem., 10, 794 (2010); Gragutan, I. et al.: Beil. J. Org. Chem., 7, 699 (2011)

Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.

Applications Labelled Sarmentine (S141600). Sarmentine is used for controlling plant pests. References Alecio, A., et al.: J. Na.t Prod., 61, 637 (1998), Duh, C., et al.: J. Nat. Prod., 53, 1575 (1990), Yang, Y., et al.: J. Agric. Food Chem., 50, 3765 (2002), Tsai, I., et al.: Planta Med., 71, 535 (2005),

Applications 4-tert-Butylaniline-d15 (CAS# 1219794-71-4) is a useful isotopically labeled research compound.

Applications n-Butyl-1,1,2,2-d4 Alcohol (CAS# 118104-91-9) is a useful isotopically labeled research compound.

Applications Isotope labelled N-Nitrosodiphenylamine (N525775), which is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211

Applications Vilazodone N-Oxide-d4 is the isotope labelled analog of Vilazodone N-Oxide (V265020); a metabolite of Vilazodone (V265000) which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Also an antidepressant. References Bartoszyk, G., et al.: Eur. J. Pharmacol., 322, 147 (1997); Heinrich, T., et al.: J. Med. Chem., 47, 4684 (2004)

Applications Amisometradine-d3, is a labeled analogue of Amisometradine (A633600), which is an oral diuretic. References Papesch, V., et al.: J. Org. Chem., 16, 1879 (1951); Moskalyk, R., et al.: J. Pharma. Sci., 64, 1406 (1975)

Leucocrystal violet-d6 is a dye that has been used for decades as a fluorescent marker for chromatographic analysis. It is commonly used as an indicator to determine the purity of acetonitrile in analytical methods. Leucocrystal violet-d6 is prepared by dissolving the dye in acetonitrile and adding it to a test sample. The solvent is then evaporated and the dye will be left behind. Leucocrystal violet-d6 has a strong absorption band at approximately 605 nm, which can be detected using a spectrometer. The major limitation of this method is that it cannot be used to analyze samples containing water or organic solvents such as methanol or ethanol.

Applications Ethane-d5-thiol (CAS# 61260-03-5) is a useful isotopically labeled research compound.

Applications Farnesyl Pyrophosphate Triammonium Salt-13C3 is labelled Farnesyl Pyrophosphate Triammonium Salt (F102470) which is an isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras. References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),