Biochemicals and Reagents

PKI (5-24) is a synthetic peptide specifically designed as a protein kinase inhibitor. Derived from a segment of the endogenous PKA inhibitor protein, this peptide is utilized to inhibit the activity of cyclic AMP-dependent protein kinase (PKA). The sequence corresponds to amino acids 5-24 of the native protein, retaining its potent inhibitory activity. PKI (5-24) functions by binding to the catalytic subunit of PKA, thus preventing the phosphorylation of downstream targets. In research settings, PKI (5-24) is applied to study PKA signaling pathways, ascertain the role of PKA in various cellular processes, and elucidate the impacts of PKA inhibition in different physiological contexts. It is particularly valuable in investigations into signal transduction, cell metabolism, and neurobiology, providing insights into mechanisms underlying disorders such as cancer and cardiovascular diseases. As an established tool in molecular biology and biochemistry, PKI (5-24) enables targeted modulation of kinase activity, thereby facilitating precise investigation of cellular signaling pathways.

The PDF antibody is a highly specialized molecule drug used in the field of Life Sciences. It is an activated antibody that acts as an anticoagulant, inhibiting the clotting process. This unique antibody has the ability to neutralize various molecules involved in blood coagulation, such as insulin, albumin, and fibrinogen. The PDF antibody is a monoclonal antibody, meaning it is derived from a single clone of cells and exhibits high specificity for its target. In human serum, this antibody has shown remarkable efficacy in inhibiting protein kinase activity, making it a valuable tool for research and therapeutic applications in the field of Life Sciences.

This antibody reacts with heavy (gamma) chains on sheep IgG and light chains on all sheep immunoglobulins.

Affinity purified Rabbit polyclonal DPRP1 antibody

Peptide H-FESSAAKLKRKYWWKNLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-FESSAAKLKRKYWWKNLK^-OH include the following: Purification and characterization of botulinum neurotoxin FA from a genetically modified Clostridium botulinum strain S Pellett, WH Tepp, M Bradshaw, SR Kalb, JK Dykes - Msphere, 2016 - Am Soc Microbiolhttps://journals.asm.org/doi/abs/10.1128/msphere.00100-15 Quantification of botulinum neurotoxin serotypes A and B from serum using mass spectrometry BA Parks, JD Shearer, J Baudys , SR Kalb - Analytical , 2011 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ac201910q

Purified Polyclonal HIC2 antibody

Mouse monoclonal Rotavirus VP6 antibody

A Cholesterol Ester Transfer Protein (CETP) light tryptic peptide standard responsible for use in protein identification and quantitation studies. CETP is an enzyme which moves cholesterol esters from high density lipoproteins (HDL) to apolioprotein B-containing particles. This action lowers the amount of HDL which may increase the risk of the disease atherosclerosis.

Mouse monoclonal SSR1 antibody

Rabbit polyclonal PLXDC2 antibody

Pneumolysin antibody is a polyclonal antibody that is used in Life Sciences research. It specifically targets pneumolysin, a protein produced by Streptococcus pneumoniae, which is responsible for causing pneumonia and other respiratory infections. This antibody has been shown to neutralize the activity of pneumolysin, preventing its damaging effects on host cells. Pneumolysin antibody can be used in various applications such as immunohistochemistry, ELISA, and Western blotting to study the role of pneumolysin in disease progression and to develop new therapeutic strategies. With its high specificity and affinity for pneumolysin, this antibody is a valuable tool for researchers in the field of infectious diseases.

TC SL C5 is a monoclonal antibody that binds to the extracellular domain of human growth hormone receptor and inhibits its activity. The antibody is useful as a research tool in cell biology, pharmacology, and ligand-receptor interactions. TC SL C5 has been shown to inhibit the activation of human platelets by thrombin, which is mediated by the binding of thrombin to its receptor on platelets. TC SL C5 also inhibits the ionic current in rat brain cells, which may be due to its ability to bind to potassium channels.

Cutamesine is a sigma-1 agonist that was shown to upregulate the transcription of neurotrophic factors in vitro. It has been shown to increase levels of dopamine and acetylcholine, as well as reducing locomotor activity in rodents. Cutamesine also inhibits the mitochondrial membrane potential, which can help prevent neurodegenerative diseases such as Parkinson's Disease. In addition, cutamesine has been shown to have anti-inflammatory properties and may be an effective treatment for infectious diseases. Low-dose cutamesine was found to have no effect on cognition or memory in mice, making it a promising therapeutic option for older adults with cognitive impairment.

Human TGF-B1(Transforming Growth Factor Beta 1) ELISA Kit

A synthetic peptide for use as a blocking control in assays to test for specificity of IDH3A antibody, catalog no. 70R-3928

Anti-Human B7-H3 Monoclonal Antibody

Topoisomerase I inhibitor

It is used in heat-exchange media, metal polishes, and thinners for lacquers/varnishes. Also used to make para-cresol, carvacrol, and synthetic resins. It is also used as a component of commercial terpene solvent mixtures. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

A synthetic peptide for use as a blocking control in assays to test for specificity of GSTM5 antibody, catalog no. 70R-2852