Biochemicals and Reagents

H-KRQISIATFTVQAAA-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KRQISIATFTVQAAA-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KRQISIATFTVQAAA-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KRQISIATFTVQAAA-OH at the technical inquiry form on this page

Human sequence expressed in E. coli Cells; purity >97% by SDS-PAGE and HPLC.

TBC1D10A antibody was raised in rabbit using the C terminal of TBC1D10A as the immunogen

A synthetic peptide for use as a blocking control in assays to test for specificity of SERPINA3 antibody, catalog no. 70R-5915

AD01 is a derivative of the FK506 binding protein-like (FKBPL), and exerts potent anti-angiogenic activity in vitro and in vivo to control tumour growth.Recent studies have shown that AD-01 inhibits Rac-1 activity, and up-regulates RhoA and the actin binding proteins, profilin and vinculin.In this way, the anti-angiogenic proteins, FKBPL, and AD-01, offer a promising and alternative approach for targeting both CD44 positive tumours and vasculature networks. Recent clinical studies have shown that AD01 and other FKBPL-based peptides may offer an alternative for targeting treatment-resistant breast cancer stem cells.

The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. Also known as the nucleocapsid protein, it is an abundant RNA-binding protein critical for viral genome packaging. These factors make nucleoprotein a good target for developing new antiviral drugs. In addition, the identification of epitopes within the nucleoprotein sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. Nucleoprotein (261-275) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.

Peptide H-VPYGSFKHV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-VPYGSFKHV-OH include the following: The Final N-Terminal Trimming of SPC HLA - J Immunol, 2002 - Citeseerhttps://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=3fcdbf53fcf0fea74f35206a45a0835c6d9d0946 Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells S Morel, F Levy, O Burlet-Schiltz, F Brasseur - Immunity, 2000 - cell.comhttps://www.cell.com/immunity/pdf/S1074-7613(00)80163-6.pdf The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides R Geiss-Friedlander , N Parmentier, U Möller - Journal of biological , 2009 - ASBMBhttps://www.jbc.org/article/S0021-9258(20)38389-7/abstract 264 MASS SPECTROMETRY: MODIFIED PROTEINS AND GLYCOCONJUGATES [11] O BURLET-SCHILTZ - : Modified Proteins and , 2005 - books.google.comhttps://books.google.com/books?hl=en&lr=&id=jFpnZTmZmngC&oi=fnd&pg=PA264&dq=(%22H-VPYGSFKHV-OH%22+OR+%22NH2-Val-Pro-Tyr-Gly-Ser-Phe-Lys-His-Val-OH%22+OR+%22VPYGSFKHV%22)+AND+peptide&ots=tXWYLrsQ6-&sig=z1dz1Gd_AFhQBSOt9RzCSxeq7Fw The use of mass spectrometry to identify antigens from proteasome processing O Burlet-Schiltz, S Claverol, JE Gairin - Methods in Enzymology, 2005 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0076687905050111 A recyclable assay to analyze the NH2-terminal trimming of antigenic peptide precursors L Burri, C Servis, L Chapatte, F Levy - Protein expression and purification, 2002 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1046592802005077 Preclinical development of dipeptidyl peptidase IV inhibitor alogliptin: a brief overview KVL Parsa , M Pal - Expert Opinion on Drug Discovery, 2011 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1517/17460441.2011.588695 Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity J Dannull, DT Lesher, R Holzknecht - Blood, The Journal , 2007 - ashpublications.orghttps://ashpublications.org/blood/article-abstract/110/13/4341/103257 Advances in understanding the expression and function of dipeptidyl peptidase 8 and 9 H Zhang , Y Chen, FM Keane, MD Gorrell - Molecular Cancer Research, 2013 - AACRhttps://aacrjournals.org/mcr/article-abstract/11/12/1487/89283 The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9 E Pilla, M Kilisch, C Lenz , H Urlaub - Journal of Biological , 2013 - ASBMBhttps://www.jbc.org/article/S0021-9258(20)48610-7/abstract Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections CF Towne, IA York , J Neijssen , ML Karow - The Journal of , 2008 - journals.aai.orghttps://journals.aai.org/jimmunol/article/180/3/1704/75825 New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors C Cui, X Tian , L Wei, Y Wang, K Wang - Frontiers in , 2022 - frontiersin.orghttps://www.frontiersin.org/articles/10.3389/fphar.2022.1002871/full

A synthetic peptide for use as a blocking control in assays to test for specificity of CLDN18 antibody, catalog no. 70R-6931

Please enquire for more information about Arachidonic acid-d5 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Peptide H-VGLPISQR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-VGLPISQR^-OH include the following: Quantification of ricin, RCA and comparison of enzymatic activity in 18 Ricinus communis cultivars by isotope dilution mass spectrometry SM Prezioso, AJ Carter, YM Williamson, SC McGrath - Toxicon, 2015 - researchgate.nethttps://www.researchgate.net/profile/David-Schieltz/publication/270595184_Quantification_of_Ricin_RCA_and_Comparison_of_Enzymatic_Activity_in_18_Ricinus_Communis_Cultivars_by_Isotope_Dilution_Mass_Spectrometry/links/54bcedaf0cf253b50e2d85ff/Quantification-of-Ricin-RCA-and-Comparison-of-Enzymatic-Activity-in-18-Ricinus-Communis-Cultivars-by-Isotope-Dilution-Mass-Spectrometry.pdf Quantification of ricin, RCA and comparison of enzymatic activity in 18 Ricinus communis cultivars by isotope dilution mass spectrometry DM Schieltz, LG McWilliams, Z Kuklenyik, SM Prezioso - Toxicon, 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0041010115000069

2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol is a research tool that can be used to study the effects of Ion channels on cells. It can also be used as a pharmacological reagent for the study of receptor binding and protein interactions. 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol has a CAS No. 848814-27-7 and is soluble in DMSO. This product is available in high purity and it does not contain any detectable impurities.

Sheep polyclonal Prednisolone antibody

Mouse monoclonal Cytokeratin 10 antibody

A synthetic peptide for use as a blocking control in assays to test for specificity of ARGFX antibody, catalog no. 20R-1259

Mirodenafil dihydrochloride is a potent phosphodiesterase-5 (PDE5) inhibitor, which is a synthetic compound with a primarily chemical origin. Its mode of action involves the inhibition of the enzyme PDE5, which predominantly resides in the smooth muscle cells lining blood vessels. By inhibiting PDE5, Mirodenafil dihydrochloride effectively increases the levels of cyclic guanosine monophosphate (cGMP), leading to the relaxation of smooth muscle tissues and vasodilation. This mechanism of action makes Mirodenafil dihydrochloride particularly effective in the treatment of erectile dysfunction (ED). By enhancing blood flow to specific areas of the body, primarily the corpus cavernosum of the penis, it facilitates the achievement and maintenance of an erection in response to sexual stimulation. The compound’s selectivity for PDE5 over other phosphodiesterases minimizes potential side effects and enhances its therapeutic efficacy. As such, Mirodenafil dihydrochloride serves as a valuable tool in clinical settings for managing erectile dysfunction, providing an alternative for patients who may not respond to or tolerate other PDE5 inhibitors.

Applications Lincomycin N-Oxide is an analog of Lincomycin (L466230). Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial. This compound is a contaminant of emerging concern (CECs). References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962);Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964);Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994)

Biotin-SARS-CoV-2 Spike RBD 371-394 peptide is the biotinylated version of SARS-CoV-2 Spike RBD 371-394 peptide. SARS-CoV-2 Spike RBD 371-394 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). Biotin-SARS-CoV-2 Spike RBD 371-394 peptide is useful for vaccine development and for structure-activity relationship studies SARS-CoV-2 Spike (S) glycoprotein Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells. With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane. SARS-CoV-2 Spike RBD: The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.