Biochemicals and Reagents

Arginase antibody was raised in rabbit using arginase isolated from bovine liver as the immunogen.

A synthetic peptide for use as a blocking control in assays to test for specificity of CHCHD6 antibody, catalog no. 70R-10068

SP6 antibody was raised in rabbit using the C terminal of SP6 as the immunogen

Characterized disease state sera are critical components in the development and manufacture of diagnostic tests. However, sourcing of these sera is complicated, time-consuming, and sometimes suitable material is not available at all. Our Toxoplasma Gondii IgM Hybrid Human Monoclonal Antibody is concentrated and spiked into an IgG depleted and delipidised human serum matrix which ensures that the final product is as close as possible to the natural disease state IgM positive human plasma. As part of the selection process for each antibody multiple clones were analysed by commercially available IgM assays and the clones with the most reactivity were selected for commercialization. Testing in both ELISA and bead-based applications shows the products behave in an almost identical manner as the natural source. Toxoplasma Gondii is a microscopic, single-celled parasite that can infect a variety of warm-blooded animals, including humans. This parasite is responsible for the disease called toxoplasmosis. Toxoplasma gondii is a member of the phylum Apicomplexa, which also includes other important parasitic organisms. The life cycle of Toxoplasma gondii involves both sexual and asexual stages. Cats, both domestic and wild, are the definitive hosts where sexual reproduction occurs. The asexual stages can occur in any warm-blooded animal, including humans. The primary modes of transmission to humans include ingestion of oocysts shed in the feces of infected cats, consumption of undercooked or raw meat containing tissue cysts. Transmission can also occur through organ transplantation and blood transfusions. In healthy individuals, toxoplasmosis may cause mild flu-like symptoms or go unnoticed. However, for individuals with weakened immune systems (such as those with HIV/AIDS, organ transplant recipients, or individuals undergoing certain medical treatments), the infection can cause more severe complications. Congenital toxoplasmosis can result in serious birth defects if a pregnant woman becomes infected.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Rabbit polyclonal AP2M1 antibody

Antibody Pair to ApoA-V antibody was raised in Mouse using a purified recombinant fragment of human Apoa5 expressed in E. coli as the immunogen.

MRPL3 antibody was raised in Rabbit using Human MRPL3 as the immunogen

Rabbit polyclonal p62 DOK antibody

Bis-Mal-Lysine-PEG4-acid

Fentanyl Conjugate for use in immunoassays

CFTR modulator

Peptide H-FSPDDSAGASALLR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-FSPDDSAGASALLR-OH include the following: Thyroglobulin and thyroid cancer WS Phipps, AN Hoofnagle , MY Roth, CM Shuford - Cancer Biomarkers, 2022 - Elsevierhttps://www.sciencedirect.com/science/article/pii/B9780128243022000060 Clinical peptide and protein quantification by mass spectrometry (MS) SKG Grebe, RJ Singh - TrAC Trends in Analytical Chemistry, 2016 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0165993615301813 Quantitation of Thyroglobulin in Serum Using SISCAPA and Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) JG van der Gugten , M Razavi, DT Holmes - Clinical Applications of Mass , 2022 - Springerhttps://link.springer.com/protocol/10.1007/978-1-0716-2565-1_42 A distributable LC-MS/MS method for the measurement of serum thyroglobulin J Shi, WS Phipps, BY Owusu, CM Henderson - Journal of Mass , 2022 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S2667145X22000396 Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies:(IMA, LC-MS/MS and RIA) I Petrovic, J LoPresti, S Fatemi - The Journal of , 2024 - academic.oup.comhttps://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae286/7659925 B-187 Evaluation of Clinical Utility of LC-MS/MS Method for Thyroglobulin Measurement in Comparison with Immunoradiometric Assay and Chemiluminescence E Yoon, S Kim, H Oh, H Park, S Kim, S Lee - Clinical Chemistry, 2023 - academic.oup.comhttps://academic.oup.com/clinchem/article-abstract/69/Supplement_1/hvad097.518/7283590 Serum thyroglobulin evaluation on LC-MS/MS and immunoassay in TgAb-positive patients with papillary thyroid carcinoma E Nishihara, Y Hobo, A Miyauchi, Y Ito - European Thyroid , 2022 - etj.bioscientifica.comhttps://etj.bioscientifica.com/view/journals/etj/11/1/ETJ-21-0041.xml First Steps Toward Harmonization of LC-MS/MS Thyroglobulin Assays To the Editor DI TgIA, B Coulter - Clinical Chemistry, 2016 - researchgate.nethttps://www.researchgate.net/profile/Stefan-Grebe/publication/282425553_First_Steps_toward_Harmonization_of_LC-MSMS_Thyroglobulin_Assays/links/5645f67108ae9f9c13e7295b/First-Steps-toward-Harmonization-of-LC-MS-MS-Thyroglobulin-Assays.pdf More sensitivity is always better: measuring sub-clinical levels of serum thyroglobulin on a µLC-MS/MS system CM Shuford, JS Johnson , JW Thompson - Clinical Mass , 2020 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S2376999820300015 Lessons learned: establishing a CLIA-equivalent laboratory for targeted mass spectrometry assays-navigating the transition from research to clinical practice CL Han, CT Lai, AJ Reyes , HC Yang, JY Lu, SR Shih - Clinical Proteomics, 2024 - Springerhttps://link.springer.com/article/10.1186/s12014-024-09455-y Clinical irrelevance of lower titer thyroglobulin autoantibodies in patients with differentiated thyroid carcinoma BL Dekker, ANA van der Horst-Schrivers - European Thyroid , 2022 - etj.bioscientifica.comhttps://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0137.xml Usefulness of a thyroglobulin liquid chromatography-tandem mass spectrometry assay for evaluation of suspected heterophile interference BC Netzel, SKG Grebe - Clinical Chemistry, 2014 - academic.oup.comhttps://academic.oup.com/clinchem/article-abstract/60/7/1016/5621619 First steps toward harmonization of LC-MS/MS thyroglobulin assays BC Netzel, RP Grant, AN Hoofnagle - Clinical , 2016 - academic.oup.comhttps://academic.oup.com/clinchem/article-abstract/62/1/297/5611812 Development of a pregnancy-specific reference material for thyroid biomarkers, vitamin D, and nutritional trace elements in serum ASP Boggs, LE Kilpatrick, CQ Burdette - Clinical Chemistry and , 2021 - degruyter.comhttps://www.degruyter.com/document/doi/10.1515/cclm-2020-0977/html Rapid and accurate quantitation of thyroglobulin biomarkers using the Echo® MS+ system with ZenoTOF 7600 system A Stella, JW McCabe, A Bhalkikar - sciex.comhttps://sciex.com/content/dam/SCIEX/pdf/tech-notes/biopharma/MKT-31267-A_Rapid_peptide_quant_FINAL_KAW_JM_APS_v4_JK.pdf Antibody Characterization for use in Clinical Mass Spectrometry A Moore - 2018 - digital.lib.washington.eduhttps://digital.lib.washington.edu/researchworks/handle/1773/42880 Thyroglobulin measurement in the management of patients with differentiated thyroid cancer A Algeciras-Schimnich - Critical Reviews in Clinical Laboratory , 2018 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/10408363.2018.1450830

H-RQIKIWFQNRRMKWKKGGGC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RQIKIWFQNRRMKWKKGGGC-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RQIKIWFQNRRMKWKKGGGC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RQIKIWFQNRRMKWKKGGGC-OH at the technical inquiry form on this page

Purified Rabbit polyclonal EPHA2/5 antibody (Tyr594)

SF 1126 is a synthetic small-molecule drug, which is derived from a benzotriazine-based scaffold. It functions as a phosphatidylinositol-3-kinase (PI3K) inhibitor with additional inhibition of mTOR, a serine/threonine kinase. This dual action mechanism disrupts critical signaling pathways involved in tumor growth and survival. The compound specifically targets PI3K, a key component of the PI3K/AKT/mTOR signaling pathway, which is often hyperactivated in various cancers. By inhibiting PI3K and mTOR, SF 1126 effectively reduces phosphorylation of downstream effectors, leading to decreased cell proliferation and induced apoptosis in tumor cells. SF 1126's applications primarily include cancer therapy, where it has been investigated for its antitumor properties in preclinical models. This compound holds promise as a therapeutic agent, particularly in malignancies exhibiting dysregulation of the PI3K/AKT/mTOR pathway. Current research explores its potential effectiveness in combination with other anticancer agents to enhance therapeutic outcomes.

H-MTAAPVHGGGGGC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-MTAAPVHGGGGGC-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-MTAAPVHGGGGGC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-MTAAPVHGGGGGC-OH at the technical inquiry form on this page

Rabbit polyclonal CSRP1 antibody (HRP)

Please enquire for more information about Glycolithocholic acid-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Pulcherriminic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

H-SAIANYAQKL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SAIANYAQKL-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SAIANYAQKL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SAIANYAQKL-OH at the technical inquiry form on this page

Region of PAI1 protein corresponding to amino acids MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFV QRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSDGSTVSV PMMAQTNKFN YTEFTTPDGH YYDILELPYH GDTLSMFIAA PYEKEVPLSA LTNILSAQLI SHWKGNMTRL PRLLVLPKFS LETEVDLRKP LENLGMTDMF RQFQADFTSL SDQEPLHVAQ ALQKVKIEVN ESGTVASSST AVIVSARMAP EEIIMDRPFL FVVRHNPTGT VLFMGQVMEP.

AATF antibody was raised in mouse using recombinant Apoptosis Antagonizing Transcription Factor

Affinity purified Rabbit polyclonal IL17 Receptor D antibody

Mouse monoclonal TUBB4 antibody

Purified Polyclonal Kalirin antibody

Peptide H-LQAEAFQAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-LQAEAFQAR-OH include the following: Quantification of total apolipoprotein E and its specific isoforms in cerebrospinal fluid and blood in Alzheimer's disease and other neurodegenerative diseases M Rezeli , H Zetterberg , K Blennow, A Brinkmalm - EuPA Open , 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S2212968515300143 EuPA Open Proteomics M Rezeli , H Zetterberg , K Blennow, A Brinkmalm - cyberleninka.orghttps://cyberleninka.org/article/n/135520.pdf

Rabbit polyclonal Ik31 antibody

Purified Polyclonal MOV10L1 antibody

GOLGB1 antibody was raised using the N terminal of GOLGB1 corresponding to a region with amino acids NKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKE

LIPG antibody was raised in rabbit using the middle region of LIPG as the immunogen

DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Armenian Hamster monoclonal PD1 antibody (FITC)

Purified recombinant CXCL2 protein (Mouse) (His tag)

Purified Polyclonal MT ND1 antibody

This peptide is phosphorylated by Janus kinase 1 (JAK1) and is an ideal substrate for use in kinase assays. The JAK family of kinases is essential for the signalling of a host of immune modulators in tumour, stromal, and immune cells where they are highly expressed. JAK family proteins mediate the signalling of the interferon (IFN), IL-6, and IL-2 families of cytokines.JAK kinases are associated with cytokine receptors. Cytokine binding to these receptors results in activation of JAK kinases and receptor phosphorylation. Phosphorylated cytokine receptors recruit STAT proteins, which are then phosphorylated by the activated JAK kinases. Phosphorylated STAT proteins form homo- and hetero-dimers that translocate into the nucleus and function as transcription factors.This JAK1 substrate peptide contains an N-terminal glycine-residue.

ApoC-I protein is a catalase enzyme that plays a crucial role in various biological processes. It exhibits catalase activity, which helps in the breakdown of hydrogen peroxide into water and oxygen. Additionally, ApoC-I protein has been found to have neutralizing effects on antiphospholipid antibodies, making it a potential therapeutic target for autoimmune disorders. This protein can also be used as a peptide agent for research purposes, as it has been shown to react with specific monoclonal antibodies. Furthermore, ApoC-I protein acts as a growth factor and is involved in regulating cell growth and development. Its glycoprotein nature makes it an essential component in various Life Sciences applications. Streptavidin can be used to detect and bind ApoC-I protein due to its high affinity for biotinylated molecules. With its multifunctional properties, ApoC-I protein is a valuable tool in Proteins and Antigens research.

ATP5B antibody was raised using the N terminal of ATP5B corresponding to a region with amino acids PIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ

Rabbit polyclonal OSBPL2 antibody

Rabbit polyclonal TLP1 antibody

Peptide derived from the Vitamin D-binding protein which binds to circulating vitamin D metabolites produced from UV-B exposure or when it is ingested in the diet. The leucine residue at position 2 is isotopically labelled with carbon-13(6) and nitrogen-15(1).

Rabbit Polyclonal STAT6 antibody

4-Aminophenyl 3,6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside

AU1 tag antibody was raised in goat using AU1 (DTYRYI) conjugated to KLH as the immunogen.

ROCK2 antibody was raised in rabbit using the middle region of ROCK2 as the immunogen

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

AMG 333 is a synthetic, non-selective acetylcholinesterase inhibitor that has been shown to be safe and effective in the treatment of Alzheimer's disease. It selectively blocks the enzyme acetylcholinesterase, which is responsible for breaking down the neurotransmitter acetylcholine. This inhibition allows more acetylcholine to remain active in synapses, resulting in better memory and cognitive function. AMG 333 is highly selective for cholinergic neurons, with minimal activity on other populations such as erythrocytes or skeletal muscle cells. AMG 333 has a pharmacokinetic profile with a half-life of approximately 3 hours and a distribution volume of 0.15 L/kg. Pharmacokinetic studies have found that this drug is rapidly absorbed after oral administration and eliminated primarily by metabolism through the liver and kidneys. !-- END DESCRIPTION -->

A synthetic peptide for use as a blocking control in assays to test for specificity of SRP54 antibody, catalog no. 70R-4849

H-SDAPIGK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SDAPIGK-OH is provided at greater that >98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SDAPIGK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SDAPIGK-OH at the technical inquiry form on this page

H-KAREFPSEQTRANSP-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KAREFPSEQTRANSP-OH is provided at greater that >80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KAREFPSEQTRANSP-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KAREFPSEQTRANSP-OH at the technical inquiry form on this page

MK2 Inhibitor III is a pharmacological agent, specifically a selective inhibitor, that intervenes in the MAPKAPK2 (MK2) signaling pathway. It is derived through chemical synthesis, designed to obstruct the activity of the mitogen-activated protein kinase-activated protein kinase 2 (MK2). This inhibition occurs through competitive binding at the ATP-binding site of MK2, effectively reducing the activity of this kinase involved in the stress response pathway. The primary application of MK2 Inhibitor III lies in its ability to modulate inflammatory processes. By inhibiting MK2, this compound can prevent the phosphorylation of key substrates involved in the production of pro-inflammatory cytokines and other related factors. Consequently, it serves as an invaluable tool in research directed towards understanding and potentially controlling inflammatory diseases. Beyond inflammation, MK2 Inhibitor III is utilized in studies exploring cellular responses to stress, apoptosis, and other pathways where MK2 plays a pivotal role. Its specificity and effectiveness make it a crucial component in dissecting complex biochemical pathways and developing therapeutic interventions targeting chronic inflammatory conditions.

Originally identified in Gila monster lizard (Heloderma suspectum), exendin-4 is an incretin mimetic, an analog of glucagon-like-peptide-1 (GLP-1), it stimulates insulin secretion and modulates gastric emptying to slow the entry of ingested sugars into the bloodstream. Exendin-4 is resistant to cleavage by plasma DPP-IV unlike GLP-1. This gives it a longer half-life and duration of action than GLP-1, as well as greater potency in vivo. Exendin-4 increases insulin sensitivity and improves glucose tolerance and is currently used for the treatment of Type 2 diabetes mellitus in its synthetic form Exenatide.Exendin-4 also promotes the production and proliferation of β-cells leading to regeneration of the pancreas. It is a ligand to the exendin receptor and increases pancreatic acinni cAMP levels. However, the GLP-1 analog was found to have a toxic effect by inducing hypotension due to relaxation of the cardiac smooth muscle.The leucine residues at positions 10, 21, and 26 of this peptide are isotopically labelled with carbon-13 and nitrogen-15, giving this peptide a mass increase of 18.5 compared to the unlabelled peptide.

cAMP antibody was raised in rabbit using succinyl-cAMP-BSA as the immunogen.

The MYD88 antibody is a growth factor that is commonly used in immunoassays. It plays a crucial role in various cellular processes, including the activation of mitogen-activated protein kinases and endonucleases. The MYD88 antibody specifically targets the p38 mitogen-activated protein kinase (MAPK) pathway, which is involved in immune responses and inflammation. By immobilizing and activating this pathway, the MYD88 antibody enhances the polymerase activity and caspase-9 activation, leading to increased cell proliferation and apoptosis. This antibody is available as both polyclonal antibodies and monoclonal antibodies, allowing for versatile applications in research and diagnostics. Additionally, the MYD88 antibody has been shown to interact with nuclear factor kappa-light-chain-enhancer (NF-κB), further contributing to its immunomodulatory properties.

The GKN1 antibody is a highly specialized monoclonal antibody that targets erythropoietin, a growth factor involved in red blood cell production. This antibody specifically binds to the erythropoietin receptor and inhibits its activity, resulting in decreased erythropoietin signaling. By blocking this pathway, the GKN1 antibody can potentially regulate red blood cell production and viscosity levels in the body. In addition to its role in regulating erythropoiesis, the GKN1 antibody has also been shown to have potential therapeutic applications in other areas of life sciences. It has been found to inhibit protein kinase activity and modulate the expression of various cytokines such as TGF-β1 and interleukin-6. Furthermore, this monoclonal antibody has demonstrated efficacy against multidrug-resistant strains of bacteria, including Helicobacter species. The GKN1 antibody is produced using advanced techniques in monoclonal antibody development and purification. It is highly specific and exhibits minimal

E260 is a bicyclic heterocycle that has been shown to be a broad-spectrum antimicrobial agent. It is active against Gram-positive and Gram-negative bacteria, mycobacteria, and fungi. E260 has also been shown to be effective against human pathogens such as HIV and methicillin-resistant Staphylococcus aureus (MRSA). E260 is structurally similar to the natural amino acid histidine and can bind to bacterial ribosomes where it inhibits protein synthesis. This drug has a high binding affinity for proteins that have an N-terminal glycine residue with a side chain of at least five carbon atoms.

Mouse monoclonal NRBP1 antibody

CD34 Monoclonal Antibody

Peptide H-SRLLEFYLAMPFATP-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-SRLLEFYLAMPFATP-OH include the following: Rapid generation of NY-ESO-1-specific CD4+ THELPER1 cells for adoptive T-cell therapy S Kayser, C Bobeta, J Feucht, KE Witte, A Scheu - , 2015 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/2162402X.2014.1002723

Peptide H-A^LPAPIEK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-A^LPAPIEK-OH include the following: High-throughput LC-MS quantitation of cell culture metabolites Z Sun, Q Ji, AR Evans, MJ Lewis, J Mo, P Hu - Biologicals, 2019 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1045105619300788 Comparison of middle-and bottom-up mass spectrometry in forced degradation studies of bevacizumab and infliximab YFK Dyck, D Rehm, K Winkler, V Sandig, W Jabs - of pharmaceutical and , 2023 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0731708523003655 Qian Dong, qian. dong@ nist. gov, 3019752569 Y Liang, X Yan, SP Markey, YA Mirokhin - tsapps.nist.govhttps://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=924777 PAWG pilot study on quantification of SARS-CoV-2 monoclonal antibody-part 1 W Mi, RD Josephs, JE Melanson , X Dai, Y Wang - Metrologia, 2022 - iopscience.iop.orghttps://iopscience.iop.org/article/10.1088/0026-1394/59/1A/08001/meta S1 Table. Complement to Fig 5: H10 antibody unique peptides detected by MS/MS in heavy chain fragment samples F1 to F6. VH EVQLVESGGGLVQPGGSLR - pdfs.semanticscholar.orghttps://pdfs.semanticscholar.org/901d/a00f161ea9e078792d783f9e42e5efec2fb6.pdf Fast analysis of antibody-derived therapeutics by automated multidimensional liquid chromatography-mass spectrometry S Pot, C Gstöttner , K Heinrich, S Hoelterhoff - Analytica Chimica , 2021 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0003267021008412 An automated high-throughput workflow for peptide mapping to monitor post-translational modifications (PTMs) of monoclonal antibodies authors S Millan-Martaca­n, C Jakes , G Oliviero , S Carillo - Thermo Fish , 2018 - lcms.labrulez.comhttps://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_21835_lc_ms_peptide_mapping_ptm_mab_an21835_en_c972b7ab57/an-21835-lc-ms-peptide-mapping-ptm-mab-an21835-en.pdf Negligible In Vitro Recovery of Macromolecules from Microdialysis Using 100 kDa Probes and Dextran in Perfusion Fluid S Dorothee, G Sorensen, LR Olsen, JF Bastlund - Neurochemical , 2024 - Springerhttps://link.springer.com/article/10.1007/s11064-024-04119-7 The NISTmAb tryptic peptide spectral library for monoclonal antibody characterization Q Dong , Y Liang, X Yan, SP Markey, YA Mirokhin - MAbs, 2018 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/19420862.2018.1436921 The Analysis of Post-Translational Modifications in Protein Biotherapeutics Using Hilic-Ms P Collop - 2020 - search.proquest.comhttps://search.proquest.com/openview/ae80b158d0c6180b5f3a215034c6450b/1?pq-origsite=gscholar&cbl=18750&diss=y Development of immunocapture-LC/MS assay for simultaneous ADA isotyping and semiquantitation LZ Chen, D Roos , E Philip - Journal of Immunology Research, 2016 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1155/2016/7682472 Research Article Development of Immunocapture-LC/MS Assay for Simultaneous ADA Isotyping and Semiquantitation LZ Chen, D Roos , E Philip - 2016 - academia.eduhttps://www.academia.edu/download/85046571/pmc4806687.pdf Absolute quantification of the total and antidrug antibody-bound concentrations of recombinant human alpha-glucosidase in human plasma using protein G extraction and KJ Bronsema , R Bischoff , WWMP Pijnappel - Analytical , 2015 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.analchem.5b00169 Investigating surrogate cerebrospinal fluid matrix compositions for use in quantitative LC-MS analysis of therapeutic antibodies in the cerebrospinal fluid JR Fogh, AM Jacobsen, TTTN Nguyen - Analytical and , 2020 - Springerhttps://link.springer.com/article/10.1007/s00216-020-02403-3 Investigation of the correlation between charge and glycosylation of IgG1 variants by liquid chromatography-mass spectrometry JM Yang, J Ai, Y Bao, Z Yuan, Y Qin, YW Xie, D Tao - Analytical , 2014 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0003269713005642 Solid-state mAbs and ADCs subjected to heat-stress stability conditions can be covalently modified with buffer and excipient molecules JF Valliere-Douglass , P Lewis, O Salas-Solano - Journal of , 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0022354915302264 Assessment of naturally occurring covalent and total dimer levels in human IgG1 and IgG2 J Yang, AM Goetze, GC Flynn - Molecular immunology, 2014 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0161589013005610 A close look at human IgG sialylation and subclass distribution after lectin fractionation J Stadlmann , A Weber, M Pabst , H Anderle - , 2009 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/pmic.200800931 Two-Dimensional Mass Spectrometry Analysis of IgG1 Antibodies J Paris , TE Morgan , BP Marzullo - Journal of the , 2021 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jasms.1c00096 Anti-Abeta antibody aducanumab regulates the proteome of senile plaques and closely surrounding tissue in a transgenic mouse model of Alzheimer's disease J Bastrup , KH Hansen, TBG Poulsen - Journal of , 2021 - content.iospress.comhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad200715 Forensic analysis of soman exposure using characteristic fragment ions from protein adducts F Fu, Y Guo, X Lu, P Zhao, S Zou - Human & , 2021 - journals.sagepub.comhttps://journals.sagepub.com/doi/abs/10.1177/09603271211001111 Absolute and multiplex quantification of antibodies in serum using PSAQ™standards and LC-MS/MS D Lebert, G Picard, C Beau-Larvor, L Troncy - Bioanalysis, 2015 - Future Sciencehttps://www.future-science.com/doi/abs/10.4155/bio.15.56 Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins C Jin , B Hantusch , W Hemmer, J Stadlmann - Journal of Allergy and , 2008 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0091674907014480 A validated LC-MS/MS method for the quantification of bevacizumab in rat, cynomolgus monkey, and human serum A Zhou, J Yu, Y Wu, H Xue, D Zhong, X Diao - Journal of Pharmaceutical , 2023 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S073170852300359X

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

TRIB1 antibody was raised in rabbit using the C terminal of TRIB1 as the immunogen

TAP1 antibody was raised using a synthetic peptide corresponding to a region with amino acids LVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL

Rabbit polyclonal NDM1 antibody (biotin)

Dopamine D2/3 agonist

Recombinant human RBP1 protein (His tag)

Rabbit polyclonal XRCC4 antibody

Purified native Human ApoE protein

FCAR antibody was raised in Rabbit using Human FCAR as the immunogen

ELISA Kit for detection of IgM in the research laboratory

Levofloxacin

Mouse monoclonal PRL antibody

A synthetic peptide for use as a blocking control in assays to test for specificity of PTDSR antibody, catalog no. 20R-1217

H-VKNWMTETLLVQNANPDC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VKNWMTETLLVQNANPDC-OH is provided at greater that >80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VKNWMTETLLVQNANPDC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VKNWMTETLLVQNANPDC-OH at the technical inquiry form on this page

Peptide H-QIVQNLR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-QIVQNLR-OH include the following: Proteomics-based approach to detect and identify major allergens in processed peanuts by capillary LC-Q-TOF (MS/MS) H Chassaigne, JV Nørgaard- Journal of Agricultural ..., 2007 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jf063630e

The BMI1 antibody is a highly specialized monoclonal antibody that has been isolated for its cytotoxic properties. It specifically targets the BMI1 protein, which plays a crucial role in cell proliferation and self-renewal. By neutralizing the activity of BMI1, this antibody effectively inhibits the growth and survival of cancer cells. In addition to its cytotoxic effects, the BMI1 antibody also has other important applications in the field of life sciences. It can be used as a research tool to study various cellular processes, such as the regulation of hepcidin or collagen production. Furthermore, it can be utilized in diagnostic assays to detect and quantify specific proteins or antigens. The high specificity and affinity of this monoclonal antibody ensure accurate and reliable results in any experiment or application. Its ability to selectively bind to target proteins enables precise antigen-antibody reactions, minimizing non-specific binding and background noise. Overall, the BMI1 antibody is an invaluable tool for researchers and scientists working in various

Purified recombinant LIPG protein (His tag)

Rabbit polyclonal PDLIM5 antibody

Peptide H-TLDFHDSNVK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-TLDFHDSNVK-OH include the following: Quantification of influenza virus hemagglutinins in complex mixtures using isotope dilution tandem mass spectrometry TL Williams, L Luna, Z Guo, NJ Cox, JL Pirkle - Vaccine, 2008 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0264410X08003022 Simultaneous quantification of hemagglutinin and neuraminidase of influenza virus using isotope dilution mass spectrometry TL Williams, JL Pirkle, JR Barr - Vaccine, 2012 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0264410X11019918 Optimization of digestion parameters for protein quantification J Norrgran, TL Williams, AR Woolfitt, MI Solano - Analytical , 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0003269709003844 Development and fit-for-purpose verification of an LC-MS method for quantitation of hemagglutinin and neuraminidase proteins in influenza virus-like particle J Guo , Y Lu, Y Zhang, S Mugabe, Z Wei - Analytical , 2020 - drive.google.comhttps://drive.google.com/file/d/1Pa-B4ZtvpoaooqaEpEVnMleFNkJfbCRB/view Amino acid analysis of peptides using isobaric-tagged isotope dilution LC-MS/MS AR Woolfitt, MI Solano, TL Williams, JL Pirkle - Analytical , 2009 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ac900367q

4-[8-[(2,6-Diethoxy-4′-fluoro[1,1′-biphenyl]-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl]benzoic acid is a potent and selective inhibitor of the ion channel TRPV1. It blocks the activation of TRPV1 channels by capsaicin, thereby preventing the transmission of pain signals to the brain. 4-[8-[(2,6-Diethoxy-4′-fluoro[1,1′-biphenyl]-4-yl)methyl]-3-oxo-2,8-- diazaspiro[4.5]decan]-2 yl]benzoic acid has been shown to inhibit peptide binding to the receptor GPCR in a ligand displacement assay. This compound also inhibits protein interactions with their partners and is

Fluphenazine decanoate is a peptide that has been used as a research tool to study the activation of ion channels and receptor interactions. Fluphenazine decanoate is an inhibitor of protein-protein interactions, and it can be used in cell biology as a reagent for labeling ligands or receptors. It has also been shown to inhibit binding of the acetylcholine receptor ligand carbachol to its receptor. Fluphenazine decanoate is chemically synthesized and purified by high performance liquid chromatography (HPLC) and characterized by nuclear magnetic resonance (NMR).

Rabbit polyclonal Keratin 7 antibody

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Mouse monoclonal MGRN1 antibody

TIE2 antibody was raised in rabbit using an 18 amino acid peptide from human TIE2 as the immunogen.

Rabbit polyclonal cJun antibody (Ser243)

LFNG antibody was raised using the N terminal of LFNG corresponding to a region with amino acids LSEYFSLLTRARRDAGPPPGAAPRPADGHPRPLAEPLAPRDVFIAVKTTK