Antibiotics

Netilmicin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis by binding to the 30S ribosomal subunit and is used for treating severe bacterial infections.

(E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin is a semisynthetic macrolide antibiotic, which is derived from erythromycin, a natural product obtained from the bacterium *Saccharopolyspora erythraea*. This compound functions as an inhibitor of protein synthesis by binding to the 50S ribosomal subunit of bacteria, thus preventing the growth and proliferation of susceptible bacterial strains. The alteration in its chemical structure, notably the methylation at the 6-O position, enhances its stability and improves its pharmacokinetic profile compared to the parent compound, erythromycin. The primary use of (E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin is in the treatment of Gram-positive bacterial infections and some Gram-negative bacterial infections, providing an effective therapeutic option for conditions such as respiratory tract infections, skin infections, and certain sexually transmitted infections. Its role in clinical settings is significant due to its broad-spectrum activity and its ability to be used as an alternative for patients who are allergic to penicillin-based antibiotics.

Amphotericin B is a macrocycle antibiotic first isolated from Streptomyces nodosus. Its antifungal activity is exerted by interacting with the fungal membrane, mainly ergosterol, and inducing pore formation. The increase in membrane permeability causes loss of ions and cell death. The C-2’ hydroxyl residue of the mycosamine carbohydrate moiety in the structure seems to have a major role in binding to ergosterol. It is used in cell culture to prevent growth of microbial contaminants, such as yeast and fungi. It is recommended by the WHO and CDC as an antifungal component for VTM at a concentration of 250ug/ml.

β-lactam antibiotic of penicillin subclass, which inhibits bacterial cell wall synthesis by targeting the proteoglycan synthesis. Cloxacillin has a narrow spectrum of action and is effective against Gram-positive organisms. Cloxacillin is resistant to the action of β-lactamase and therefore preferentially used for treatment of Staphylococcal infections.

Broad spectrum, long-acting and lipid soluble tetracycline antibody

Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant

26-Oxofusidic acid is a derivative of fusidic acid, which is a potent antibacterial compound originally isolated from the fungus Fusidium coccineum. This compound exhibits a unique mode of action by inhibiting bacterial protein synthesis through interference with the elongation factor G (EF-G), a critical component in the translocation step of translation. By targeting this specific aspect of bacterial metabolism, 26-Oxofusidic acid effectively disrupts the growth of gram-positive bacteria, making it an invaluable tool in combating resistant bacterial strains. In terms of its applications, 26-Oxofusidic acid is primarily utilized in clinical settings to treat infections caused by Staphylococcus aureus, including methicillin-resistant strains (MRSA). Its efficacy extends to other gram-positive pathogens, providing an alternative when common antibiotics fail due to resistance issues. The compound's distinctive mechanism also presents opportunities for its use in research settings, particularly in studies aimed at understanding bacterial resistance mechanisms and developing novel antibacterial strategies. Overall, 26-Oxofusidic acid stands as a critical asset in both therapeutic and experimental microbiology contexts.

Erythromycin, is used as a macrolide antibiotic protein synthesis inhibitor. It is widely used in cell culture applications. Depending upon the strain of bacteria, erythromycin has been used between 50 and 200 mg/L to control bacterial growth. Erythromycin resistance can be induced in bacteria. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.