Antibiotics

Gramicidin S hydrochloride is a cyclic peptide antibiotic, which is a derivative of the naturally occurring antibiotic gramicidin S. It is sourced from Bacillus brevis, a type of soil bacterium. This peptide operates through a unique mode of action, whereby it disrupts bacterial cell membranes. By integrating into the lipid bilayer, it increases membrane permeability, leading to leakage of essential ions and molecules, and ultimately causing cell death. Gramicidin S hydrochloride is primarily used in scientific research to study antibiotic mechanisms and membrane biology, given its potent ability to affect membrane integrity. Additionally, it holds potential for applications in developing novel antimicrobial agents, particularly in exploring resistance mechanisms and testing efficacy of new compounds. Its role in research is essential for advancing our understanding of peptide-based antimicrobial strategies, making it an invaluable tool in the fields of microbiology and pharmacology.

Myriocin is a potent fungal metabolite that is an inhibitor of sphingolipid biosynthesis. It is originally sourced from the ascomycete fungus *Isaria* sinclairii. Myriocin functions by specifically inhibiting serine palmitoyltransferase, the key enzyme in the de novo sphingolipid biosynthesis pathway, effectively reducing the production of ceramides and sphingomyelins. This mechanism of action makes Myriocin a significant tool in the study of sphingolipid metabolism and signaling pathways. In terms of applications, Myriocin is valuable in biochemical and pharmacological research, particularly in studies involving sphingolipid-associated cellular processes and disorders. It has shown promise in the modulation of immune responses and the investigation of diseases such as multiple sclerosis and diabetes, where sphingolipid metabolism plays a crucial role. Additionally, Myriocin serves as a lead compound for the development of therapeutic agents targeting sphingolipid-related pathways. Its utility in experimental settings underlines its importance in advancing our understanding of lipid-mediated cellular mechanisms.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Phenothiazine (ENT 38) is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Stability Hygroscopic Applications 25-Deacetyl-23-acetyl Rifampicin is a structural isomer, and impurity, of Rifampicin (R508000), a semisynthetic antibiotic. Antibacerial (tuberculostatic). References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),