Antibiotics

Dihydrostreptomycin sesquisulfate is an aminoglycoside antibiotic, which is derived from the bacterium Streptomyces griseus. Its mode of action involves binding to the 30S subunit of the bacterial ribosome, leading to the disruption of protein synthesis. This binding interferes with the initiation complex formation, causing misreading of mRNA and ultimately inhibiting bacterial growth. The primary use of dihydrostreptomycin sesquisulfate is in the treatment of infections caused by Gram-negative bacteria. It has been employed in veterinary medicine to address respiratory and gastrointestinal infections in livestock. However, due to its ototoxic and nephrotoxic potential, its use in humans has been largely discontinued in favor of less toxic alternatives. This antibiotic is particularly effective against Mycobacterium tuberculosis and other mycobacteria, offering a robust option in combating bacterial diseases. Researchers should note the importance of proper dosing to mitigate resistance development and toxicity risks. Understanding the specific interactions at the ribosomal level can guide the strategic development of novel antibiotics with reduced side effects and enhanced efficacy.

Faropenem sodium hemipentahydrate is a penem-class beta-lactam antibiotic with action on bacterial cell wall synthesis and is used for treating respiratory, skin, and urinary tract infections.

Vidarabine is a nucleoside antibiotic from Streptomyces with antiviral properties, effective against herpes and other DNA viruses.

Inhibits respiration in mitochondria. Also inhibits ATP synthase This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Hymeglusin is an HMG-CoA synthase 1 inhibitor with pro-apoptotic and anti-leukemic activity. Hymeglusin decreases the expression level of BCL2 in HL-60 and KG-1 cells.

A sulfanilide anti-bacterial agent used to treat various skin diseases

MLEB-22043 is a synthetic siderophore-monocyclic β-lactam conjugate which enters bacteria through TonB-dependent transport proteins utilizing its siderophore component, subsequently exerting antibacterial activity via its β-lactam portion. This compound acts as a broad-spectrum antibiotic, exhibiting significant inhibitory activity against pathogens such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.

Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative bacteria.