Antibiotics

Nafcillin sodium monohydrate is a beta-lactam antibiotic, which is derived from the penicillin class of antimicrobials. It is specifically a semi-synthetic penicillin and is commonly sourced through chemical synthesis to enhance its stability and spectrum of activity. Nafcillin primarily exerts its bactericidal effects by inhibiting bacterial cell wall synthesis. It achieves this through its strong affinity for penicillin-binding proteins (PBPs), which are essential for maintaining the bacterial cell wall structure. By disrupting the formation of peptidoglycan cross-links, nafcillin effectively weakens the bacterial cell wall, leading to cell lysis and death, especially in gram-positive bacteria such as Staphylococcus aureus, including methicillin-sensitive strains (MSSA). Nafcillin sodium monohydrate is predominantly used in clinical settings to treat serious infections like endocarditis, osteomyelitis, and septicemia caused by susceptible organisms. Its stability against penicillinase makes it a preferred choice for treating infections that are resistant to other beta-lactams. This antibiotic is typically administered via intravenous or intramuscular routes to ensure optimal bioavailability and therapeutic efficacy in targeting systemic infections.

Ciprofloxacin, inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Netilmicin sulfate (Netromycin) is an aminoglycoside antibiotic.

A semisynthetic penicillin with wide spectrum of antimicrobial activity, particularly pseudomonas strains. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.