Antibiotics

A protein synthesis inhibitor. Causes apoptosis of PC12 Cells This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Reagent used in the preparation of Cephalosporin antibiotics. References Choi, K., et al.: J. Antibiotics, 50, 279 (1997), Bharathi, C., et al.: J. Pharm. Biomed. Anal., 43, 733 (2007),

MsbA-IN-6: potent antibiotic, hinders MsbA in gram-negative bacteria, kills E. coli, effective on drug-resistant strains.

Antibiotic of penicillin class; inhibits bacterial cell wall biogenesis

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Sulopenem is a thiopenem antibiotic with action on bacterial cell wall synthesis and is used for treating uncomplicated urinary tract infections.

Nitrocycline is a broad-spectrum antibiotic, which is a synthetic derivative of tetracycline with enhanced antibacterial properties. As a chemically synthesized compound, nitrocycline has been engineered to overcome resistance mechanisms common in bacterial pathogens. Its mode of action involves the inhibition of protein synthesis, achieved by binding to the 30S ribosomal subunit, effectively preventing the addition of new amino acids to nascent peptide chains. This binding action interrupts bacterial growth and replication, providing robust activity against both Gram-positive and Gram-negative bacteria. Nitrocycline is primarily utilized in clinical settings to combat resistant bacterial infections that are unresponsive to traditional antibiotics. Its applications extend to severe infections such as those caused by multi-drug resistant strains of Staphylococcus aureus and enterococci. Additionally, it has been found effective in treating respiratory, urinary tract, and skin infections. The synthetic nature of nitrocycline allows for modifications to its structure, enabling the enhancement of its pharmacokinetic properties and spectrum of activity. This positions nitrocycline as a promising candidate in the ongoing effort to address the escalating challenge of antibiotic resistance globally.

Leptomycin B is a bacterial secondary metabolite, which is derived from the bacterium Streptomyces sp. This compound is a potent nuclear export inhibitor with a mechanism of action that targets and inhibits the export receptor CRM1 (Chromosomal Maintenance 1), also known as Exportin 1. By binding irreversibly to CRM1, Leptomycin B prevents the nuclear export of proteins and RNA, disrupting the nuclear-cytoplasmic transport essential for cell function. As an inhibitor of nuclear export, Leptomycin B has crucial applications in research settings, particularly in the study of cellular processes and diseases involving nucleocytoplasmic transport. It is frequently used to explore cancer biology, cell cycle regulation, and viral infections, providing insights into the role of nuclear export in these contexts. Additionally, Leptomycin B’s ability to modulate nuclear transport pathways makes it a valuable tool for dissecting the molecular underpinnings of various cellular mechanisms, offering potential leads for therapeutic interventions.