Heterocycles with Nitrogen (N)

Please enquire for more information about 2-Chloro-N-[2-(cyclopropylamino)-4-methyl-3-pyridinyl]-3-pyridinecarboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Ethoxy-5-(trifluoroMethyl)pyridine-3-boronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Methylpyrimidin-2-ol is a photophysical, hydroxy group, and hydroxyl group. It has been shown to have an inhibitory effect on DNA methylation by glycosidic bond with the sugar moiety of the nucleotide. 5-Methylpyrimidin-2-ol reacts with the base moiety of the nucleotide to form an analog that inhibits RNA synthesis and is competitive against pyrimidine nucleosides. 5-Methylpyrimidin-2-ol also has a hydrogen bonding property that can react with other molecules such as proteins or sugars to form hydrogen bonds. This reaction rate is increased by fluorescence resonance energy transfer (FRET).

Please enquire for more information about 2H-Pyrido[2,3-d][1,3]oxazin-2-one,7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-,Hydrochloride(1:1) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylsulfonylpyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Methoxy-3-methylpyridine-5-boronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-Carboxy-1-(4-fluorobenzyl)pyridinium bromide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Furo[2,3-c]pyridin-5-ylmethanol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Etoricoxib is a cyclooxygenase-2 (COX-2) inhibitor, which is a type of nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the enzyme COX-2 that is involved in the production of certain hormones called prostaglandins. These hormones are involved in the inflammation (swelling and heat) associated with conditions such as arthritis. By blocking the action of the COX-2 enzyme, etoricoxib reduces the production of prostaglandins and thus, reduces the inflammation and pain. It has been observed that Etoricoxib shows a higher selectivity for COX-2 over COX-1 in diverse studies, with a COX-1/COX-2 IC50 ratio of 344 for in vitro assays, and it is involved in the modulation of NF-ΚB/COX-2/PGE2 signaling.

Applications N-Acetylpiperazine-d4 is labelled N-Acetylpiperazine-d4 which was used to prepare (aryl)sulfanyltriazoles with HIV-1 non-nucleoside reverse transcriptase inhibiting activities. It was also used to synthesize diphenylpyrazolecarboxamides as heat shock protein chaperone inhibitors and anticancer agents. References Wang, Z., et al.: Bioorg. Med. Chem. Lett., 16, 4174 (2006); Brough, P., et al.: J. Med. Chem, 51, 196 (2008)