Amides

1H-Imidazole-2-carbothioic acidamide is a synthetic compound that belongs to the imidazole derivatives. It has bactericidal activity and is used as an agricultural fungicide. This molecule contains a hydroxy group, an alicyclic section, nitrogen atoms, and two stereoisomers.

2H-Pyrazole-3-carbothioic acid amide (2HPCA) is a new chemical entity that inhibits the replication of several viruses, including human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and vesicular stomatitis virus (VSV). It has been shown to be active against HCT116 cells in cell culture. 2HPCA has been developed as an innovative antiviral agent with potential use for the treatment of cancer. It binds to nucleophilic sites on viral DNA polymerase and inhibits viral replication. 2HPCA is currently being tested for its effect on other cancers, such as colorectal cancer and pancreatic cancer.

4-Acetylbenzenesulfonamide is an organic compound that has been used in the synthesis of many other compounds. It is a substrate for human liver alcohol and glucuronide enzymes, which are responsible for its pharmacokinetic properties. The affinity of 4-acetylbenzenesulfonamide to ciprofloxacin, a fluoroquinolone antibiotic, has also been studied extensively. 4-Acetylbenzenesulfonamide has been found to have antibacterial activity against Staphylococcus aureus and Escherichia coli. It also has shown anticancer activity in colon cancer cells by arresting the cell cycle at G2/M phase.

Fluorescein-6-iodoacetamide is a fluorescent probe that binds to Lysine residues of human immunoglobulins. It is used in the analytical method for measuring protein synthesis, which is based on the incorporation of fluorescein-6-iodoacetamide into proteins by enzymatic hydrolysis. Fluorescein-6-iodoacetamide has also been used as a marker for cellular metabolism and energy production. This compound reacts with disulfide bonds to form fluorescent products, which can be detected using low light and fluorescence spectroscopy.

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N-Ethyl-2-(piperidin-3-yloxy)acetamide is a fluorinated solvent that is used as a replacement for the more toxic solvent perchloroethylene. It is used in the electronics industry, metal finishing, and as an ingredient in paints and waxes. N-Ethyl-2-(piperidin-3-yloxy)acetamide has been shown to be environmentally safe because it does not harm the ozone layer and does not contribute to acid rain. This substance also has low toxicity and low volatility. The emissions of this chemical are minimal and not a risk to human health or the environment. The life cycle of this chemical includes its production, use, and disposal. Research on this substance integrates all three stages of its life cycle into one study in order to better understand how they affect each other.

Metoclopramide is a prokinetic drug that acts on the gastrointestinal tract by increasing gastric motility and peristalsis. It is also used to treat nausea and vomiting, especially in patients receiving chemotherapy. N-Desethyl metoclopramide is a metabolite of metoclopramide and has been detected in human urine at high concentrations following administration of the drug. Urinary metabolites may be analysed using high-performance liquid chromatography (HPLC) with UV detection. The metabolites can then be identified by comparison with reference standards or spectrometry. Metoclopramide has been shown to have antiemetic properties in animals and humans, but its mechanism of action remains unknown.

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2-Chloro-4-nitrobenzamide is a drug that belongs to the sulfa drugs. It has been shown to be effective in treating autoimmune diseases, particularly bowel disease and inflammatory bowel disease. 2-Chloro-4-nitrobenzamide inhibits the synthesis of fatty acids by blocking the enzyme acetyl CoA carboxylase, which is involved in the formation of long chain fatty acids. This drug also has immunosuppressive activities, which may be due to its ability to block T cell proliferation. 2-Chloro-4-nitrobenzamide is used as a chemical intermediate for antibiotics such as maduramicin ammonium and salinomycin sodium. It is also used as a dietary supplement or pharmaceutical dosage form for cardiac glycoside drugs such as digoxin.

N-[4-(2-Bromoacetyl)phenyl]methanesulfonamide is a chiral biocatalytic agent, which is synthesized by chemoenzymatic or enzymatic reactions. It has been used in enantioselective synthesis of 4-aminoacetophenone and as an antiarrhythmic agent. This compound is not active against bacterial infections.

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2-Hydroxy-5-[1-hydroxy-2-(3-phenylpropyl)amino]ethylbenzamide (HET0016) is an anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody that binds to the PCSK9 receptor. This binding prevents PCSK9 from binding to LDL receptors, which leads to increased degradation of LDL receptors and reduced uptake of LDL cholesterol. This drug has been shown to reduce cholesterol levels and is being used in clinical trials for the treatment of coronary heart disease. HET0016 also reduces blood pressure in patients with hypertension and can be used as a monotherapy or in combination with other drugs, such as labetalol or metoprolol. It has also been shown to increase glucose tolerance in mice by increasing insulin secretion. There are no known drug interactions or adverse effects associated with HET0016.

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Applications Reproduction of Sindbis virus strains sensitive and resistant to 1-adamantanecarboxamide. References Erice, A., et al.: N. Engl. J. Med., 320, 289 (1989), Andronova, V.L., et al.: Bull. Exper. Bio. Med., 129, 74 (2000).

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(2R)-2-Aminopropanamide is a chemical compound that is classified as an amide. It has been shown to inhibit bacterial growth and induce apoptosis in mammalian cells, but not in bacteria. This drug has a number of hydrogen bonding interactions with the carbonyl group and amide functional groups and can bind to affinity ligands with hydrogen bonding interactions. (2R)-2-Aminopropanamide inhibits the activity of enzymes that are involved in the synthesis of d-alanine, which is a precursor for protein synthesis. It also inhibits the enzyme glutamine synthase, which plays a key role in building up nitrogen reserves in bacteria. The drug binds to DNA by forming hydrogen bonds with the phosphate backbone and intercalates into double-stranded DNA by forming van der Waals interactions with base pairs.

M06217 - Fmoc-D-Cys(Acm)-OH

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M06060 - H-Phe.pNA