Lactones

6'-Dehydromarmin is a natural product, classified as a coumarin derivative, which is primarily sourced from certain plant species, notably within the Rutaceae family. This compound arises through the biochemical transformation of secondary metabolites in plants, typically involving oxidation processes that occur under specific enzymatic conditions. The mode of action of 6'-Dehydromarmin is rooted in its ability to interact with various biological pathways. It exhibits a range of activities, including antifungal and antimicrobial properties, by disrupting cellular processes within pathogens. This disruption often involves interference with cell wall synthesis and enzyme inhibition, contributing to its efficacy as a bioactive molecule. In terms of uses and applications, 6'-Dehydromarmin is of significant interest in the fields of pharmacology and biochemistry due to its potential therapeutic roles. It is studied for its antimicrobial capabilities, offering a natural alternative for combating resistant microbial strains. Additionally, its role as a model compound in studying plant-derived coumarins underscores its value in scientific research, particularly in understanding plant defense mechanisms and secondary metabolism.

Columbianadin is a coumarin derivative, which is a natural compound primarily extracted from plants in the Apiaceae family, such as Angelica species. This natural product possesses a unique molecular structure characterized by the presence of a coumarin skeleton, which is responsible for its diverse biological activities. Columbianadin acts through various biochemical pathways, showing potential inhibitory effects on certain enzymes and modulating inflammatory responses in biological systems. Its mode of action is attributed to its ability to interact at the molecular level, influencing signaling pathways and cellular processes that are crucial in disease progression and immune responses. Given its biological properties, Columbianadin has been studied for its potential applications in pharmacological research. It has shown promise in anti-inflammatory, anti-cancer, and neuroprotective studies, contributing to a greater understanding of therapeutic mechanisms. Though still under investigation, its role in modulating key biological pathways highlights the importance of this compound in drug discovery and development.

4-Phenyl-7,8-dihydroxycoumarin (7,8-Dihydroxy-4-phenylcoumarin) inhibits the activity of Staphylococcus aureus DNA helicase

Herniarin (Ayapanin) is a natural coumarin with antitumor effect.

Imperatorin, a biologically active furanocoumarin from the roots of Angelica dahurica (Umbelliferae), can induce apoptosis in human promyelocytic leukaemia, HL-60 cells,

Applications This compound has estrogenic activity. It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution. References Wolfbeis, O.S. & K. Schaffner: Photochem. Photobiol., 32, 143(1980), Bickoff et al.: J.Am. Chem Soc. 80, 3969 (1958)

Marmin is a natural bioactive compound, which is a type of limonoid. It is primarily sourced from citrus fruits, especially those belonging to the Rutaceae family, such as lemons and oranges. The compound exhibits a range of biological activities due to its multifaceted mode of action. Marmin functions as a calcium antagonist, which contributes to its vasodilatory effects, improving blood circulation and exhibiting potential cardiovascular benefits. Additionally, it shows anti-inflammatory and antioxidant properties, making it relevant in the context of oxidative stress-related conditions. Its action may influence pathways involved in inflammation and cellular damage, thus highlighting its therapeutic potential. The compound’s uses extend to various applications in pharmacological research. Scientists are exploring its potential roles in preventing cardiovascular diseases, reducing inflammatory responses, and managing oxidative stress. The ongoing studies aim to elucidate its efficacy and safety profile, providing insights into possible therapeutic applications. Marmin's bioactivity makes it an intriguing subject for further investigation in both fundamental research and potential clinical settings.

Lactone

Lactone

5-Methoxysuberenone is a chemical constituent of the root bark of Toddalia asiatica (L.) Lam. (T. aculeata Pers.), Rutaceae.

Fraxinol is a natural lignan, which is a small class of polyphenols, derived from the inner bark of the Ash tree (Fraxinus species). Its primary action is believed to involve antioxidant and anti-inflammatory pathways, where it scavenages reactive oxygen species and modulates cytokine production. This activity suggests potential modulation of cellular oxidative stress responses, contributing to its therapeutic interest. The compound is being studied extensively for its potential medicinal applications. These include its use as a supplement in the management of inflammatory conditions and as an adjunct in therapies addressing oxidative stress-related diseases. Additionally, due to its bioactivity, Fraxinol is being explored in various experimental setups to elucidate its full pharmacological spectrum, particularly in relation to its impact on cellular signaling and gene expression modification pathways. These studies aim to uncover new insights into its possible application in clinical settings.

Phellopterin: partial central benzodiazepine receptor agonist, cytotoxic at 40-400 μM on RAW264.7 cells, inhibits VCAM-1, affects monocyte adhesion.

Nodakenin, a coumarin isolated from the roots of Angelica biserrata (Shan et Yuan) Yuan etShan, possesses neuroprotective, antiaggregatory, antibacterial, and memory