Lactones

Scopoletin-2',3'-epoxy-3'-methylbutyl ether is a synthetic derivative of scopoletin, which is a coumarin compound. This ether derivative is primarily obtained from chemical synthesis processes designed to modify the parent compound, scopoletin, which is naturally found in various plants, such as those in the Asteraceae and Rubiaceae families. The mode of action typically involves the modulation of biochemical pathways, primarily through interacting with enzymes or receptors that regulate oxidative stress or inflammation. Scopoletin-2',3'-epoxy-3'-methylbutyl ether is under investigation for its potential uses in pharmacology, particularly in anti-inflammatory and antioxidant therapies. Its structural modifications aim to enhance bioavailability and increase efficacy in biological systems compared to its natural analogs. Researchers are exploring its applications in mitigating chronic inflammatory diseases and conditions involving oxidative stress, which are linked to a wide range of pathologies, including cardiovascular diseases and certain types of cancer.

Applications 7-Hydroxy Coumarin-d5 Sulfate Potassium Salt is the labeled analogue of 7-Hydroxy Coumarin Sulfate Potassium Salt (H924890), a metabolite of 7-hydroxycoumarin (7-HC). Found in hepatocyte, microsome, S9 fraction of human, dog, monkey, rat and mouse liver. References Ekins, S., et al.: Drug Metab. Dispos. 24, 990 (1996); Bock, K., et al.: Biochem. Pharmacol. 66, 691 (2003); Naritomi, Y., et al.: Drug Metab. Dispos. 31, 580 (2003)

Lactone

Cichoriin is a photosensitive compound, it could be used as herbal photosensitizing agent in treating benign breast tumor in rats.

Scoparone is a bioactive natural compound, which is primarily derived from plants in the Rutaceae family, such as Artemisia species. It is a coumarin derivative, known for its therapeutic properties due to its diverse biological activities. The mode of action of scoparone is multifaceted, involving the modulation of various enzymes and signaling pathways. It acts as an inhibitor of cytochrome P450 enzymes and influences pathways involving nitric oxide and reactive oxygen species, contributing to its anti-inflammatory and hepatoprotective effects. Scoparone's uses and applications are extensive in the fields of pharmacology and biochemistry. It is actively researched for its potential in treating liver-related disorders, such as hepatic fibrosis and jaundice, due to its ability to modulate enzyme activity and reduce oxidative stress. Additionally, scoparone exhibits significant anti-inflammatory and antioxidant properties, making it a topic of interest for treating conditions characterized by excessive inflammation. Furthermore, its role as a model compound for studying coumarin derivatives enhances its value in scientific research, expanding its relevance beyond purely therapeutic applications.

Lactone

8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat

7-Geranyloxycoumarin is a naturally occurring coumarin derivative, which is primarily sourced from plant species in the Rutaceae family. It is a bioactive compound known for its presence in various essential oils and its contribution to the properties of these plant extracts. The mode of action of 7-Geranyloxycoumarin involves interactions at the cellular level, including enzyme inhibition and modulation of signal transduction pathways, which can lead to diverse pharmacological effects. This compound has been studied for its multifaceted applications, including anti-inflammatory, antioxidant, and anticancer activities. In scientific research, it is investigated for its potential to modulate biological pathways and its ability to act as a chemical probe in the study of cellular processes. Additionally, 7-Geranyloxycoumarin is of interest in the development of novel therapeutic agents due to its wide range of biological activities. It serves as a noteworthy example of the vast potential held by natural compounds in the advancement of pharmaceutical and biochemical research.

Umbelliferone or 7-hydroxycoumarin is a widespread natural product of the coumarin family. It occurs in many familiar plants from the umbelliferae family. Umbelliferone can be used as a fluorescence indicator for metal ions such as copper and calcium. It acts as a pH indicator in the range 6.5-8.9.

Scopolin is a coumarin glucoside, which is derived from the plant secondary metabolism. It originates predominantly from species within the Solanaceae family, including tobacco and potato plants. Its biosynthesis involves the conversion of scopoline, a precursor molecule, through glucosylation. This process is catalyzed by glucosyltransferases, which facilitate the attachment of a glucose moiety. Scopolin functions primarily as a phytoalexin, engaging in defense mechanisms within plants. It accumulates in response to pathogenic attack or environmental stressors, acting to inhibit the growth of pathogens through antimicrobial properties. Additionally, scopolin participates in lignin biosynthesis, contributing to cell wall fortification, which enhances the structural integrity and resistance of the plant. Research into scopolin has unveiled its role in plant defense signaling pathways and potential applications in agricultural biotechnology. By bolstering plant resilience to diseases and environmental stresses, scopolin can contribute to more sustainable crop production practices. Its implications for enhancing plant viability under stress conditions remain a significant interest in advancing agricultural science.

Lactone