Antifungals

Fosravuconazole is a ravuconazole prodrug. It has antifungal activity.

Penthiopyrad (MTF-753) shows a broad spectrum of antifungal activity and suppresses fungal respiration.

Applications Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride. Alamethicin contains the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib), which strongly induces helical peptide structures. In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Afonin, S., et al.: Chembiochem., 4, 1151 (2003), Henriques, S., et al.: Biochem. J., 399, 1 (2006), Almeida, P., et al.: Biochemistry, 48, 8083 (2009), Heitz, F., et al.: Br. J. Pharmacol., 157, 195 (2009),

Applications 2-[(6-Chloro-4-pyrimidinyl)oxy]-α-(dimethoxymethyl)benzeneacetic Acid Methyl Ester is an impurity of Azoxystrobin (A965150), an strobilurin fungicide. References Liu H.J., et al.: J. Chin. Chem. Soc., 60, 27 (2013);

Exalamide (2-(Hexyloxy)benzamide) is an aromatic amide with antifungal activity used in the study of dermatophytes.

Ipconazole is a fungicide with a mode of action that inhibits ergosterol biosynthesis, disrupting fungal cell membranes. It is used for seed treatment to protect crops like cereals and vegetables from fungal diseases.

Prothioconazole (Proline 480 SC Fungicide) is a chiral triazole fungicide in plant pathogen control.

α-Terpinene is a terpenoid,has acaricidal, antiprotozoal, and antioxidant properties

Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).

Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity.

2,5-Dimethyl-3(2H)-furanone (2,5-Dimethyl-2,3-dihydrofuran-3-one) is a non-genotoxic flavoring substance [1].

Prochloraz: broad-spectrum imidazole fungicide; blocks placental aromatase (IC50=40nM), estrogen/androgen receptors; activates aryl hydrocarbon receptors.

Flumorph (SYP-L190) (SYP-L190) is a carboxylic acid amide fungicide.

Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.