Antifungals

Applications Curvulin is a phototoxin that inhibits microtuble assembly.

Butenafine hydrochloride is an antifungal agent and is used for the treatment of fungal infections. It inhibits the synthesis of ergosterol, a key component of fungal cell membranes.

Piperlonguminine is an alkaloid amide isolated from the Piper species.

Sordarin sodium salt is an antifungal agent, characterized as a semisynthetic derivative produced from the fermentation products of filamentous fungi, specifically belonging to the phylum Ascomycota. This compound exerts its effects by selectively inhibiting fungal protein synthesis. It achieves this by obstructing the function of elongation factor 2 (EF-2), an essential component of fungal ribosomal activity, thereby disrupting the translational elongation step of protein synthesis. The primary uses and applications of Sordarin sodium salt lie in the study of fungal infections and the development of antifungal therapies. Due to its specific mechanism of targeting fungal organisms without affecting human cells, it is a valuable tool in biochemical and pharmacological research. Scientists employ it to elucidate the molecular pathways involved in fungal growth and replication, providing insights that could lead to novel antifungal drug development. Its specificity and mode of action make it an important subject in research directed at combatting resistant strains of fungi, contributing to the broader field of infectious disease management.

Impurity of Micafungin; anti-fungal

Anti-fungal; sterol 14α-demethylase inhibitor

WQ3810 TFA is an orally available fluoroquinolone with antimicrobial activity against Mycobacterium tuberculosis and inhibits the DNA rotamase activity of

NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.

Naftifine N-Oxide is an antifungal agent, which is derived from synthetic chemical processes. Its structure is based on the modification of the known antifungal, naftifine, by introducing an N-oxide functional group, which may enhance certain pharmacokinetic properties. As a synthetic derivative, Naftifine N-Oxide is specifically designed to interfere with the biosynthesis of ergosterol, an essential component of fungal cell membranes. By inhibiting squalene epoxidase, an enzyme crucial to the ergosterol pathway, Naftifine N-Oxide effectively disrupts the development and maintenance of the fungal cell membrane, compromising cell integrity and leading to antifungal activity. The primary applications of Naftifine N-Oxide involve the treatment of various dermatophyte and yeast infections affecting the skin. These conditions include tinea pedis, tinea cruris, and other superficial mycoses where intervention targets fungal growth at the site of infection. It is utilized in topical formulations given its mechanism of action and target site, providing a localized antifungal effect that minimizes systemic exposure. The unique structure and mode of action of Naftifine N-Oxide contribute to its potential use in developing formulations that specifically target fungal pathologies resistant to other antifungal agents.

Applications 1,4-Bis([1,1'-biphenyl]-4-ylphenylmethyl)-1H-imidazole is derived from 5-([1,1’-Biphenyl]-4-ylphenylmethyl)-1H-imidazole (B397925), which is a structural isomer of Bifonazole (B383400) that is an anti-fungal agent used in the treatment of skin diseases. Bifonazole causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells. References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);

Antifungal 1-(4-AMinophenyl)-2(1h)-pyridinone inhibits Candida, Aspergillus, Pseudomonas, and Staphylococcus.

Triadimefon is an azole fungicide used to control powdery mildew.

Antifungal agent 76 has broad-spectrum antifungal activity with a MIC value of 0.25-16 μg/mL.Antifungal agent 76 may act by disrupting fungal cell membranes and can be used to study fungal infections.