Antivirals

Applications A stable labelled selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product. References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153(2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)

Carbovir triphosphate triethylamine is a nucleotide analog, which is a derivative of nucleoside analogs designed for antiviral applications. It is synthesized through chemical modification of guanosine analogs, resulting in its active triphosphate form. This compound functions as a potent antiretroviral agent by mimicking natural nucleotides and interfering with viral DNA synthesis. The active triphosphate impedes the action of viral reverse transcriptase by incorporating itself into the viral DNA chain, causing premature termination and effectively halting viral replication. In scientific research, Carbovir triphosphate triethylamine is primarily explored for its efficacy against HIV-1. Its mechanism of action provides insights into developing therapeutic strategies to manage retroviral infections. The compound’s ability to inhibit viral replication makes it a valuable tool in the study of drug resistance mutations and antiviral drug development. Researchers focus on its pharmacokinetics, metabolic stability, and potential to overcome existing challenges in antiviral therapy. The detailed study of such compounds aids in the advancement of novel treatments and the enhancement of current antiviral regimens.

Applications (+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties. References Ganatra, S.H., et al.: J. Comp. Sys. Biol., 5, 68 (2012); Abaza, M.S. I., et al.: Tumor. Biol., 33, 1951 (2012); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012); Shishido, T., et al.: J. Virol., 86, 9055 (2012);

Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist. References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);

ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.

Impurity Ribavirin EP Impurity C Applications 1,2,4-Triazole-3-carboxylic Acid (Ribavirin EP Impurity C) is a major metabolite of the antiviral agent Ribavirin (R414475). References Miller, J.P. et al.: Ann. N.Y. Acad. Sci., 284, 211 (1977); Catlin, D. et al.: Ribavirin: Broad Spec. Antivir. Ag., 83 (1980); Lin, C.C. et al.: Antimicrob. Ag. Chemother., 50, 2368 (2006);

JNJ-49095397 (RV568) is a p38 MAPK-α and p38 MAPK-γ kinase inhibitor for the study of respiratory syncytial virus infection.

PI4KIII beta inhibitor

SARS-CoV-2 3CLpro-IN-20 is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.43 μM,).SARS-CoV-2 3CLpro-IN-20 has potential antiviral activity.

Zalcitabine (also known as dideoxycytidine or ddC) is a nucleoside analogue reverse transcriptase inhibitor (NRTI) medication used in the treatment of human immunodeficiency virus (HIV) infections. It works by blocking reverse transcriptase, an enzyme essential for replication of the HIV virus, thereby preventing the virus from multiplying and spreading. Zalcitabine is often used in combination with other antiretroviral drugs to effectively treat HIV/AIDS. Zalcitabine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Chaparrinone, a quassinoid derived from the root of Eurycoma harmandiana, exhibits antimalarial and cytotoxic properties, with IC50 values of 0.037 μg/mL

Applications Labelled Pleconaril (P580350). Picornavirus replication inhibitor. Antiviral. References Kearns, G.L., J. Clin. Pharmacol., 39, 613 (1999), Schmidtke, M. et al.: Antiviral Res. 81, 56 (2009)

Applications 2-Fluoro-3-methoxyaniline is a reagent that is used in the structure-activity relationship studies on a series of cyclopentane-containing macrocyclic inhibitors of hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Raboisson, R., et al.: Bioorg. Med. Chem. Lett., 18, 4853 (2008)

Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Applications An impurity of Tenofovir (T018500(P)). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral. References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Applications An intermediate in the synthesis of Ritonavir.

6'-O-Galloylsalidroside has antiviral activity and inhibits HIV.

MBX2329 is a specific inhibitor of HA-mediated viral entry that inhibits H1N1 virus strain high pathogenic avian influenza H5N1 virus strain.

LCC-12 FA is a dimer of metformin, which reduces inflammation in mouse models of bacterial and viral infections and can be used to study metabolic diseases.

DNA polymerase-IN-1 exhibits antiproliferative activity against tumor cells and inhibits Taq DNA polymerase as a DNA polymerase inhibitor.