Antivirals

3'-Azido-3'-deoxy-5-methylcytidine inhibits HIV-1 reverse transcriptase(EC50 = 0.06 μM) and is an effective inhibitor of xenotropic murine leukemia-related

Applications 5,6,7,8-Tetrahydro-1-naphthalenol was used as a reagent in the synthesis of phosphonamidate and phosphonodiamidate prodrugs of adefovir and tenofovir which are used in the treatment of HIV infections. Also used in the synthesis of tetrahydronaphthalene-1-ol derivatives which were found to be promising potent antitumor agents. References Pertusati, F., et al.: Eur. J. Med. Chem., 78, 259 (2014); Dong, Y., et al.: Bioorg. Med. Chem. Lett., 19, 6289 (2009);

Selective and potent inhibitor of sialidases (neuraminidases) in influenza A and B viruses. The compound binds tightly to the viral neuraminidase active site in late stages of viral life-cycle. It inhibits shedding sialic acids from host cell surface glycans, which interact with viral hemagglutinin, and consequently prevents release of new viral particles from the host cell surface.

Sodium Camptothecin: plant-derived, antitumor, inhibits RNA/DNA synthesis, disrupts viral DNA.

Indinavir monohydrate is an antiretroviral medication, which is a synthetic pharmaceutical compound, specifically a protease inhibitor, used in the treatment of HIV infection. It is derived from chemical synthesis processes that follow rigorous standards to produce a pharmacologically active compound. Indinavir functions by selectively inhibiting the HIV-1 protease enzyme, which is crucial for the viral replication cycle. By binding to the active site of the enzyme, indinavir prevents the cleavage of viral polypeptides, leading to the production of immature and non-infectious viral particles. The primary use of indinavir monohydrate is in highly active antiretroviral therapy (HAART) regimens, often in combination with other antiretroviral agents, to effectively reduce viral load and increase CD4 cell counts in patients infected with HIV-1. This contributes to delaying the progression of the disease to AIDS and improving the quality and duration of life in affected individuals. Its application extends to both initial and salvage therapy in the management of HIV, providing a critical component in the arsenal of pharmaceutical interventions against the virus.

Applications Cabotegravir O-β-D-Glucuronide is a metabolite of Cabotegravir (C050100), a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)

IND24 has anti-prion activity and can be used to study neurodegenerative diseases.

BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.

Applications Picornavirus replication inhibitor. Antiviral. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kearns, G.L., J. Clin. Pharmacol., 39, 613 (1999), Schmidtke, M. et al.: Antiviral Res. 81, 56 (2009)

Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product. References Kim, C., et al.: J. Med. Chem., 41, 2451 (1998), Carbain, B., et al.: Chem. Med. Chem., 4, 335 (2009),

Inarigivir ammonium, an antiviral dinucleotide, lowers HBV DNA and activates innate immunity via RIG-I agonism.

Dihydromollugin is a naphthol ester found in Rubia cordifolia that may have anti-tumour, virus-inhibiting and other activities.

Bemnifosbuvir (AT-511) is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.

DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

Antiviral agent 17, EC50 0.015 μM in human assay, effective against murine norovirus, may aid infectious/malignant disease research.

Inhibitor of viral neuraminidase enzyme, effective against influenza A and B viruses. This antiviral compound inhibits neuraminidase-mediated cleavage of host cell sialic acids, which interact with newly synthesised virions from the host cell. This prevents virion budding from the host, resulting in inhibition of virion release and viral infection overall.

Betulone is a triterpenoid. It has a role as a metabolite. It derives from a hydride of a lupane.

Adefovir: acyclic nucleoside phosphonate, reverse transcriptase inhibitor for hepatitis B and herpes treatment.

Impurity Ritonavir EP Impurity E Applications Hydroxy Ritonavir (Ritonavir EP Impurity E) is a metabolite of Ritonavir (R535000), HIV-1 protease inhibitor. It is a COVID19-related research product. References Eagling, V., et al.: Br. J. Clin. Pharmacol., 48, 543 (1999), Eagling, V., et al.: Xenobiotica, 32, 1 (2002), Meaden, E., et al.: J. Antimicrob. Chemother., 50, 583 (2002), Treijtel, N., et al.: Drug Metab. Dispos., 33, 1325 (2005),