Antivirals

Applications Protected Tenofovir (T018500). Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases.  Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM).

Applications An Intermediate in the preparation of Indinavir and also a metabolite of Indinavir. It is a COVID19-related research product. References Askin, D., etal.: Tetrahedron Lett., 35, 673 (1994), Lin, J.H., et al.: Drug Metab. Dispos. 24, 1111 (1996).

Stability Hygroscopic Applications A selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral. It is a COVID19-related research product. References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998), Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999), Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

SARS-CoV-2 nsp13-IN-1 (C1) inhibits nsp13 ssDNA+ATPase (IC50: 6 μM), not ssDNA-ATPase; useful for COVID-19 research.

(R,1R)-Tenofovir amibufenamide ((R,1R)-HS-10234) can be used as a Tenofovir prodrug, which can be taken orally and has antiviral activity.

Applications 2-epi-Darunavir is a stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product. References Rao, R.N., et. al.: J. Sep. Sci., 35, 2671 (2012); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)

D-Ribulose has potential as an anticancer and antiviral compound and is a rare sugar used in the food, agricultural and pharmaceutical industries.

Applications Darunavir intermediate, a potent inhibitor of HIV-1 protease. References Debouck, C., et al.: Drug Dev. Res., 21, 1 (1990), Krohn, A., et al.: J. Med. Chem., 34, 3340 (1991), Sham, H., et al.: Antimicrob. Agents Chemother., 42, 3218 (1998),

Applications Simeprevir, is a hepatitis C virus (NS3/4A) protease inhibitor, used for the cure and treatment of hepatitis C. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lin, T., et al.: Antimicrobial Agents and chemotherapy, 53 (4), 1377 (2009); J. Hepatology, 55 (2), 1377 (2011);

Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi.

Oosporein is a mycotoxin produced by Trichoderma reesei with antimicrobial, antiviral and insecticidal activities and is used in the study of viral infections.

2'-C-beta-Methylguanosine (2'-C-Methylguanosine), with antiviral activity, inhibits dengue virus 2.

Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of

Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral. References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Applications Non-nucleoside Reverse Transcriptase inhibitor. An antiviral agent. References Qin, B., et al.: J. Med. Chem., 53, 4906 (2010), Woolfson, A., et al.: Int. J. Pharm., 388, 136 (2010), Johnson, T., et al.: Eur. J. Pharm. Sci., 39, 203 (2010),

Moroxydine hydrochloride (ABOB hydrochloride) is a synthetic antiviral drug chemically belonging to the series of the heterocyclic biguanidines.

Rimantadine is an anti-viral drug that is used for the prevention of influenza A infection. This drug is an RNA synthesis inhibitor and exerts its effects on the viral replication cycle. Although not fully understood, it is said that the M2 gene may play a role in Rimantadine susceptibility. Rimantadine HCl is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Applications 5’-O-Benzoyl Ribavirin is an impurity of Ribavirin (R414475). Ribavirin impurity E. References Zakharieva., et al.: Bioorganic. Medicinal. Chem., 1994, 4, 2831 (1994), Reichard., et al.: The Lancet, 351, 83 (1998),

Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant

Applications Antiviral agent. Used for the treatment of severe acute respiratory syndrome (SARS). References Weber, G., et al.: Cancer Res., 43, 3466 (1983), Broet, P., et al.: J. Clin. Oncol., 19, 2778 (2001), Galmarini, C., et al.: Leukemia, 15, 875 (2001), Barth, R., et al.: Cancer Res., 64, 6287 (2004), Song, M., et al.: Bioorg. Med. Chem., 12, 489 (2004),

Applications A deuterated acyclic phosphonate nucleotide analogue, reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),