Antivirals

Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.

Yadanziolide A is a natural product isolated from the cultivated dry seeds of Brucea javanica, has strong antiviral activities with IC50 of 5.5 μM against

Applications Labelled Biliverdine is a precursor of Bilirubin. Biliverdine is formed in the body from hemoglobin. The bile of amphibians and of birds contains Biliverdine only. It is also an inhibitor for hepatitis C virus. References Lemberg et al.: Biochem. J., 35, 363 (1941); Gutierrez-Grobe, Y. et al.: Annals. Hepatol., 10, 105 (2011);

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.

Nucleoside analog with antiviral activity against coronaviruses, hepatitis and influenzas viruses. EIDD 1931 inhibited the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the murine hepatitis virus (MHV) replication in vitro at submicromolar concentrations. EIDD 1931 is able to evade the proofreading exonuclease ExoN and presents with high barrier to development of drug resistance.

Anti-viral; thymidine analogue; DNA plymerase inhibitor

Applications Dasabuvir is an antiviral drug used in the treatment of chronic hepatitis C virus (HCV) infection. References Khatri, A., et al.: J. Hepatol., 63, 805 (2015);

Anti-viral; HIV integrase inhibitor

Dalimycin (Oxytetracycline Hydrochloride), from Streptomyces rimosus, blocks tRNA binding, hindering protein synthesis.

Inhibitor of viral protein NS5B

MK-28 is a PERK agonist that reduces toxicity in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells.

Non-nucleoside inhibitor of reverse transcriptase; anti-viral

Stability Hygroscopic Applications Tenofovir (T018500) impurity.

Stability Moisture sensitive Applications Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Mackman, R., et al.: Bioorg. Med. Chem., 15, 5519 (2007), Baudy, R., et al.: J. Med. Chem., 52, 771 (2009),

Ledipasvir D-tartrate is an antiviral compound, which is a direct-acting antiviral agent used in the treatment of hepatitis C virus (HCV) infection. It originates from synthetic sources designed to inhibit the replication of specific viral proteins. Ledipasvir functions by targeting the NS5A protein of the hepatitis C virus, a key component necessary for viral replication. By binding to this protein, Ledipasvir disrupts and inhibits the HCV replication complex, effectively suppressing the viral load in patients. Utilized primarily in the context of chronic hepatitis C treatment, Ledipasvir D-tartrate is typically employed in combination with other antiviral medications, such as sofosbuvir, to enhance therapeutic efficacy. This combination therapy has shown significant success in achieving sustained virologic response in various genotypes of HCV, reducing morbidity and preventing progression to liver-related complications. The use of Ledipasvir D-tartrate in clinical settings underscores its importance in modern antiviral strategies against chronic HCV infection, representing a critical advancement in the management of this pervasive viral disease.

6-Fluoro-3-hydroxypyrazine-2-carboxamide is a potent RNA polymerase inhibitor, active against both RNA viruses in vitro and in vivo. A four-step approach to the synthesis of 6-Fluoro-3-hydroxypyrazine-2-carboxamide was reported in 2014. 6-Fluoro-3-hydroxypyrazine-2-carboxamide is commercialized and has recently been suggested for the treatment of mild cases of COVID-19.

Inhibitor of HIV-1 integrase strand transfer; antiviral

Zapnometinib (ATR-002) is a MEK inhibitor.

RNA polymerase (RdRp) inhibitor

FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).

Rociclovir PM (2-[(2-aminopurin-9-yl)methoxy]propane-1,3-diol) is a compound with antiviral activity

Applications N,9-O-Diacetylneuraminic Acid is a primary receptor determinant of influenza C virus. References Rogers, G., et al.: J. Biol. Chem., 261, 5947 (1986); Herrler, G., et al.: EMBO J., 4, 1503 (1985);

Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.

Impurity Tenofovir Impurity Stability Light Sensitive Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);