Antivirals

Applications A deuterated, potent and selective inhibitor of HIV-1 replication. References Mitsuya, H., et al.: Nature, 325, 773 (1987), Brehm, J., et al.: Biochem., 47, 14020 (2008), Paredes, R., et al.: J. Virol., 83, 2038 (2009), Wan, J., et al.: J. Med. Chem., 52, 1144 (2009), Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009),

ITMN4077 is an antiviral that inhibits Hepatitis C replication in HuH7 cells, with an EC50 of 2.131μM.

Applications Daclatasvir Dihydrochloride is an anti-hepatitis C drug. References Song, B., et. al.: Zhongguo Xinyao Zazhi, 22, 2679 (2013); Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

IM-250 possesses antiviral activity with IC values of 25 nM - 100 nM.

Impurity Tenofovir Disoproxil USP Related Compound A Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A. References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Applications Elenolic Acid is an antiviral agent that inhibits reverse transcriptases, inhibited the growth of chicken embryo fibroblast cells as well as Escherichia coli and Bacillus subtilis strains. References Heinze, J.E., et al.: Antimicrob. Agents Chemother., 8, 421 (1975); Renis, H,E..: Antimicrob. Agents Chemother., 8, 149 (1975)

Balapiravir is an antiviral agent, which is a synthetic derivative based on natural compounds, specifically designed to inhibit the replication of various viral pathogens. The source of Balapiravir integrates bio-based elements with modifications to enhance its therapeutic efficacy. The mode of action of Balapiravir involves its interference with the viral RNA polymerase enzyme, effectively halting the synthesis of viral RNA. This mechanism prevents the proliferation of the virus within the host cells, thereby reducing viral load and ameliorating disease symptoms. Balapiravir finds its applications in the treatment of viral infections such as influenza and certain emerging viral diseases. It is particularly significant in managing outbreaks due to its broad-spectrum activity. Research is ongoing to expand its application to include various other viral strains, enhancing its utility and adaptability across different viral challenges. The focus on Balapiravir underscores its potential as a strategic tool in antiviral therapy, contributing significantly to the clinical management and prevention of viral pathogenicity.

Applications Labelled Nevirapine (N391275), a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral. References Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991), Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993), Guay, L.A., et al.: Lancet, 354, 795 (1999),

Anti-viral; NS5A protein inhibitor

Applications Labelled Dapivirine (D185500). Non-nucleoside Reverse Transcriptase inhibitor. An antiviral agent. References Qin, B., et al.: J. Med. Chem., 53, 4906 (2010), Woolfson, A., et al.: Int. J. Pharm., 388, 136 (2010), Johnson, T., et al.: Eur. J. Pharm. Sci., 39, 203 (2010),

Raltegravir is an antiretroviral agent that is used for the treatment of HIV infections. It inhibits HIV integrase in order to prevent viral genome from being inserted into the human genome. It binds to the active site of the enzyme and prevents it from binding to a target sequence on the viral DNA. This drug is metabolized by glucuronidation. Raltegravir potassium is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Calcitriol Impurities D: Vitamin hormone, promotes cell differentiation, has bone activity, inhibits HIV, and aids in treating AIDS/viral infections.

Ganciclovir is an antiviral agent specifically designed for culture media use. It is a synthetic analogue of 2'-deoxy-guanosine, derived from nucleoside compounds, and operates primarily by inhibiting the replication of viral DNA. Its mode of action involves selective phosphorylation by viral kinases, which converts it into ganciclovir triphosphate, a potent inhibitor of viral DNA polymerase, ultimately preventing viral DNA synthesis. In scientific settings, Ganciclovir is frequently employed in the selective inhibition of viral replication within culture media, allowing for precise studies of cellular or viral interactions without interference from unwanted viral proliferation. Its specificity makes it an invaluable tool for virologists and molecular biologists conducting research in environments where control of viral replication is crucial. The precision in its application assists in obtaining clear, unconfounded results, particularly in studies related to viral pathogenesis and the development of antiviral therapies.

Equisetin is a secondary metabolite, which is produced by the fungus *Fusarium equiseti*. It operates predominantly through the inhibition of protein synthesis and interference with cellular processes within target organisms. Equisetin exhibits potent antibacterial and antifungal activities primarily by interfering with cell wall synthesis in bacteria and disrupting key pathways in fungi. The applications of Equisetin are chiefly in the fields of pharmaceutical research and agricultural science. In pharmaceutical research, it serves as a template for developing new antibiotics due to its unique mode of action and effectiveness against resistant microbial strains. In the realm of agriculture, Equisetin is investigated for its potential as a biocontrol agent to protect crops from pathogenic fungi and bacteria, thereby reducing reliance on synthetic chemical pesticides. The exploration of Equisetin’s structure and activity also provides valuable insights into natural product biosynthesis and potential novel therapeutic pathways.

Applications 3-(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione is an impurity of Zidovudine (A825000). Zidovudine is an antiviral agent used in the clinical treatment of HIV infections. References Radatus, B.K., Org. Process. Res. Dev., 15, 1281 (2011)

Applications Oseltamivir (O701000) impurity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Muller, N., et al.: J. Phys. Chem., 83, 1393 (1979), Katritzky, A., et al.: Chem. Rev., 104, 175 (2004),

Daclatasvir is a direct-acting antiviral agent, which is derived from synthetic chemical sources with a specific mode of action targeting the hepatitis C virus (HCV) replication process. It functions as an inhibitor of the HCV nonstructural protein 5A (NS5A), a vital component necessary for viral RNA replication and virion assembly. By binding to two distinct domains of NS5A, Daclatasvir disrupts its ability to function, thereby effectively halting the replication of the viral genome. This product is primarily used in the treatment of chronic hepatitis C infection in adults. When combined with other antiviral agents, Daclatasvir exhibits significantly enhanced therapeutic efficacy, allowing for a potent suppression of the virus across various genotypes. Its clinical applications are especially noteworthy in patients with complex treatment histories or resistance to other regimens. The introduction of Daclatasvir has marked substantial progress in HCV therapeutic strategies, contributing to increased cure rates and improved patient outcomes. Its development underscores the critical role of targeted antiviral therapies in managing viral infections and showcases the potential of molecular-level interventions in clinical settings.