Antivirals

Fosamprenavir calcium is an antiretroviral medication, which is derived from the prodrug of amprenavir. It is synthesized through chemical processes to enhance oral bioavailability and improve pharmacokinetic properties. Through its mode of action, fosamprenavir is converted in vivo to amprenavir, which acts as an inhibitor of the HIV-1 protease enzyme. By inhibiting this enzyme, it prevents the cleavage of the Gag-Pol polyprotein, disrupting viral replication and processing, ultimately leading to the production of immature, non-infectious viral particles. Fosamprenavir calcium is primarily used in the management and treatment of HIV-1 infection in combination with other antiretroviral agents. It serves a critical role in antiretroviral therapy regimens due to its efficacy in reducing viral load and increasing CD4 cell counts in infected individuals. The utilization of fosamprenavir calcium is crucial in the ongoing efforts to manage HIV, contributing to improved patient outcomes and prolonged survival rates. This protease inhibitor is especially significant for patients requiring potent and reliable treatment options in the fight against HIV/AIDS.

Applications Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product. References Patick, A.K., et al.: Antimicrob. Agents Chemother., 40, 292 (1996), Bardsley-Elliot, G.L., et al.: Drugs, 59, 581 (2000)

Applications Rimantadine-d4 Hydrochloride is an isotope labeled version of Rimantadine Hydrochloride, an antiviral agent. References Hayden, F.G., et al.: Antimicrob. Ag. Chemother., 19, 226 (1981), Zlydnikov, D.M., et al.: Rev. Infect. Dis., 3, 408 (1981),

Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product. References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),

Stability Hygroscopic Applications A metabolite of Lamivudine (L172500). References Burgess, K., et al.: Chem. Rev., 100, 2047 (2000), Gallois-Montbrun, S., et al.: Biochem. Pharmacol., 68, 1749 (2004),

Enpatoran (M5049) hydrochloride is a strong, oral TLR7/8 inhibitor (IC50: 11.1/24.1 nM), inactive against TLR3/4/9, with good pharmacokinetics.

Applications N2-Des(L-valinyl) N2-Acetyl Lopinavir is a metabolite of Lopinavir (L469480); a selective HIV protease inhibitor and antiviral. It is a COVID19-related research product. References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998); Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999); Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

Applications Member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product. References Vacca, J.P., et al.: Proc. Nat. Acad. Sci. USA, 91, 4096 (1994), Dorsey, B. D., et al.: J. Med. Chem., 37, 3443 (195), Balani, S.K., et al.: Drug Metab. Dispos., 23, 266 (1995)

Filociclovir is a novel antiviral agent, which is synthesized from small-molecule pharmaceutical compounds. It functions primarily by inhibiting viral DNA polymerase, thereby halting viral replication within infected host cells. This mechanism of action is particularly effective against certain herpesviruses, as it targets the polymerase enzyme that is critical for viral DNA synthesis and proliferation. Filociclovir's applications are focused on combating viral infections, specifically those caused by herpesviruses, including cytomegalovirus (CMV). It has shown promise in preclinical studies for potentially treating conditions such as CMV retinitis in immunocompromised individuals. Further investigations are ongoing to explore its efficacy and safety profile, aiming to expand its usage for broader antiviral therapeutic applications. The compound's targeted mechanism offers potential advantages in treating difficult-to-manage viral infections, making it a valuable candidate for future drug development and clinical studies within the field of antiviral research.

Anti-viral; NS3/4A protease inhibitor

3'-Fluoro-3'-deoxythymidine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis,which is less susceptible to inflammatory changes than FDG.

Impurity Ritonavir EP Impurity J Applications N-[(1S,2S,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic Acid 5-Thiazolylmethyl Ester (Ritonavir EP Impurity J) is an intermediate in the synthesis of Ritonavir (R535000), a selective HIV protease inhibitor used for the treatment of HIV infections and AIDS. References Hamada, Y., et al.: Bioorg. Med. Chem., 10, 4155 (2002);

Applications Efavirenz penteneyne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent. References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)

β-Anomer shows antiviral properties.

Braco-19 is a telomerase/telomere inhibitor and an inhibitor of HAdV viral replication with antiviral activity that reduces lipid vacuolization in adipocytes, inhibits proliferation and decreases telomerase activity in human glioblastoma cells.

Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.

Impurity Oseltamivir EP Impurity E Stability Hygroscopic Applications Oseltamivir EP Impurity E It is a COVID19-related research product.