Antivirals

Applications 2'-Fluoro-2'-deoxyuridine-5,6-d2 (CAS# 362049-50-1) is a useful isotopically labeled research compound.

Anti-viral; capsid inhibitor

SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.

Applications Daclatasvir, inhibits the HCV protein NS5A, and thus can be used as a drug candidate for the treatment of hepatitis C (HCV). References Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

Applications 2-Hydroxy-2-methylpropanethioamide is an thioamide compound integrated as an constituent in the synthesis of Ritonavir (R535000) and its derivatives.

Peramivir is a neuraminidase inhibitor used to treat influenza by preventing virus release from cells.

Tenofovir diphosphate is an antiviral compound, which is a key active metabolite derived from the prodrugs tenofovir disoproxil fumarate and tenofovir alafenamide, both originating from chemical synthesis. Its mode of action involves inhibiting the activity of HIV-1 reverse transcriptase by competing with the natural substrate, deoxyadenosine 5’-triphosphate, and causing chain termination after incorporation into viral DNA. This mechanism effectively prevents the replication of retroviral DNA, thus halting the progression of the infection. The primary uses and applications of Tenofovir diphosphate focus on the treatment and prevention of human immunodeficiency virus (HIV) infection. It plays a crucial role in antiretroviral therapy regimens due to its potency and high barrier to resistance. Additionally, it is employed in pre-exposure prophylaxis (PrEP) strategies for individuals at high risk of contracting HIV. The inclusion of Tenofovir diphosphate in combination therapies enhances the overall efficacy and durability of the antiviral response in patients, contributing significantly to the management of HIV/AIDS.

CBS1117: influenza A entry inhibitor; blocks HA fusion, IC50=70 nM for H1N1.

Applications A reactant used in the preparation of carbocyclic deoxyguanosine analog with potent and selective anti-hepatitis B virus. References Bisacchi, G. et al.: Bioorg. Med. Chem. Lett., 7, 127 (1997)

Ethacrysta hydrochloride (GNS561 hydrochloride) is a PPT1 inhibitor with antifibrotic properties and may be used in studies of hepatocellular carcinoma.

Applications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),

ABI-1968 has antiviral and antitumor activity and can be used to study immune system diseases.

Stability Hygroscopic Applications Digallic Acid is an intermolecular ester of Gallic acid (G188900), a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities. References Yen, G. et al.: Food Chem., 79, 307 (2002); Chen, C. et al.: Mol. Nutrit. Food Res., 51, 962 (2007); Kratz, J. et al.: Mem. Inst. Oswaldo Cruz, 103, 437 (2008); Osborne, L. et al.: Infect. Immun., 33, 769 (1981)