Antiparasitics

Propamidine acts as a covalent inhibitor of TMPRSS2 and exhibits antibacterial properties. [1]

MBP146-78 is a potent and selective cGMP inhibitor dependent protein kinases.

Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.

Mepartricin, a polyene macrolide, exhibits both antifungal and antiprotozoal activities and is extensively utilized in studies related to benign prostatic hyperplasia.

Diminazene is a trypanocidal agent.

Laetanine, exhibits antiplasmodial activity, a noraporphine alkaloid from Litsea laeta.

Amodiaquine is a synthetic aminoquinoline, used to treat malaria.

PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for DNA and RNA biosynthesis.

Applications An intermediate in the synthesis of the metabolite of Nitazoxanide. References Honma, K., et al.: Chem. Pharm. Bull., 24, 394 (1976),

Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.

Febrifugine dihydrochloride (Propyldazine hydrochloride) is a biochemical with therapeutic activity regarding malaria, cancer, fibrosis and inflammatory

Phytol is a diterpene alcohol with antinociceptive, antioxidant, anti-inflammatory, and antiallergic properties, activating PPARα.

Clorsulon (L631529) is utilized for the treatment of Fasciola hepatica infections in calves and sheep.

Applications 2-((1r,4r)-4-(4-Chlorophenyl)cyclohexyl)-1-oxo-1H-indene-3-carboxylic Acid is the Indene isomer of Atovaquone (A793500)

NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic

FIKK9.1-IN-1 (Compound 1), an antimalarial agent (IC50: 2.68 μg/mL), serves as a FIKK9.1 inhibitor by interacting with the ATP-binding residues within FIKK9.1,

Compound 17k, also known as Antileishmanial agent-30, effectively inhibits Leishmania with an IC50 of 0.2 μM for L. donovani. It exhibits a CC50 of >100 μM and an SI of >500, indicating significant selectivity and potency.

4-(2-Aminoethyl)amino-7-chloroquinoline (N1-(7-Chloroquinolin-4-yl)ethane-1,2-diamine) has potential anthelmintic and antitumor activity for the study of

Piperaquine is a bisquinoline antimalarial compound and a companion compound to artemisinin.

Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.

Dinotefuran (MTI-446), a neonicotinoid insecticide, targets pests by blocking their nervous system.

Nifursemizone (Etafurazone) is an agent with antiprotozoal.

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.

Lapachol (CI75490): antimicrobial, anti-inflammatory, analgesic, antibiotic, inhibits epithelial tumors in Drosophila.

β-Mangostin: a xanthone in Cratoxylum arborescens, fights bacteria, malaria, tuberculosis (MIC 6.25μg/mL), and cancer.

Sulfaquinoxaline sodium salt (SQ-Na) is a veterinary broad-spectrum antimicrobial agent, which can be used to prevent coccidiosis and bacterial infections.

Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.

Antitrypanosomal agent 16 functions as a potent trypanocide, exhibiting an inhibitory concentration 50 (IC50) of 0.04μM against the T.

Stability Hygroscopic Applications Deoxydihydroartemisinin is used in biological studies antimalarial and possible antitumor effects via oxidative stress, modulated by hypoxia, in microendothelial cells. References D’alessandro, S., et al.: Biochem. Pharm., 82, 476 (2011);

SIBA, a synthetic SAH analog, inhibits SAM-dependent transmethylation and blocks HSV-1 replication.

Antimalarial agent 48 (Compound 15a) is a triazine compound with antimalarial activity, showing effectiveness against Plasmodium falciparum K1 and Plasmodium falciparum FCR3 with IC50 values of 280 and 290 nM, respectively. It holds promise for research in the field of anti-infective treatments.

CRK12-IN-2, a potent CRK12 inhibitor, has EC50 of 3.2 nM for T. congolense and 0.08 nM for T. vivax; treats trypanosomiasis in animals.

Resorantel: hydroxybenzanilide cestocide, combats Paramphistomum spp., Thysaniezia spp., Moniezia; researches G. aegypticus and paramphistomiasis in livestock.

Toltrazuril is an anticoccidial agent with action on protozoal parasites by disrupting their intracellular development and is used for treating coccidiosis in livestock and poultry.

1. dl-Maackiain (Demethylpterocarpin) induces apoptosis and growth suppression 2. MAK1 is the second functional gene cloned from Maackiain detoxification.

Impurity Ivermectin EP Impurity K Applications 3,4-Dihydro Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178

Abametapir (BRN 0123183), a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development.

TMF, derived from M. exotica, shows anti-malarial, fungal, mycobacterial, and anti-inflammatory effects, targeting β-catenin for joint protection.

8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it has

PIQ-2 (compound 54) serves as an antiprotozoal agent, displaying potent activity against IP. falciparum 3D7 and B. divergens Rouen, with IC50 values of 9.4 nM and 1.6 nM, respectively.

Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent .

PF 1022A is a cyclooctadepsipeptide, which is a type of cyclic peptide composed of amino acids and hydroxy acids. It is derived from the fermentation products of the fungus *Mycelia sterilia*, a member of the *Rosellinia* genus. Its mode of action involves disrupting glutamate-gated chloride channels in parasitic nematodes, which leads to paralysis and eventual death of the parasite. PF 1022A is primarily used for its anthelmintic properties, making it useful for controlling parasitic worm infections in animals. The compound's ability to selectively target nematodes without significant harm to the host organism makes it a valuable tool in veterinary medicine. It serves as a key component in formulations designed to combat gastrointestinal nematodes in livestock and pets, contributing to enhanced health and productivity in affected animals. Research into PF 1022A continues to explore its full potential and further applications in parasitology.

Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.

Benznidazole is an antiprotozoal agent and is used for the treatment of Chagas disease. It generates free radicals that damage the DNA and other cellular components of the parasite.

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Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).

Antimalarial agent 45 (compound 8I) is an antimalarial with activity against Plasmodium parasites, exhibiting an IC50 of 0.21 μM. It is used in the study of malaria.

Ornidazole (Levo-) (Levornidazole) is the levo-isomer of Ornidazole.

Doramectin is a macrocyclic lactone antiparasitic agent with action on glutamate-gated chloride channels in parasites and is used for treating internal and external parasitic infections in livestock.

TSO-13 is an inhibitor of the major cysteine protease Cruzipain found in Trypanosoma cruzi, with an IC50 of 2.2 μM. In Vero cells, TSO-13 also suppresses T. cruzi, exhibiting an IC50 of 1.9 μM.

Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.

Antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against Leishmania donovani promastigotes (IC 50 = 4.1 μM) and inhibits infection by

Fenbendazole is a benzimidazole anthelmintic with action on microtubule formation in parasites and is used for treating gastrointestinal parasites in animals.

Temephos is an organothiophosphate insecticide and cholinesterase inhibitor for treating water with disease-carrying insects.

Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM.

D-Phenothrin is a synthetic pyrethroid used in vet medicine for pest control and to kill insects, mosquitoes, and lice.

Amoscanate is an antischistosomal agent, which is a synthetic compound with a broad spectrum of activity against parasitic infections. Its mode of action involves the disruption of parasite metabolism and structure, ultimately leading to the elimination of schistosomes. Schistosomes are trematode worms responsible for schistosomiasis, a significant parasitic disease affecting millions of people worldwide. In terms of its applications, Amoscanate is primarily used in the treatment and management of schistosomiasis, where it targets both the adult and larval stages of the parasite. The synthetic origin of Amoscanate allows for precise adjustments in its chemical structure, optimizing efficacy and minimizing adverse effects. Research on its mechanism indicates that Amoscanate interferes with key biological pathways within the parasite, thereby eradicating the infection. While its current use might be focused on helminthic diseases, ongoing studies aim to elucidate additional therapeutic potential. The growing interest in this compound underscores the need for novel therapies in the treatment of neglected tropical diseases.

Levamisole is a synthetic imidazothiazole derivative belonging to the family of anthelmintic drugs. It is a nicotinic acetylcholine receptor (nAChR) agonists that binds to nAChRs on the neuromuscular junctions of parasitic worms, mimicking the action of the neurotransmitter acetylcholine. This excessive stimulation of nAChRs leads to persistent depolarization of muscle cells and spastic paralysis to expel of the worms. Levamisole exhibits broad-spectrum activity against various roundworms, whipworms, hookworms, and threadworms. Levamisole HCl is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Proguanil hydrochloride, a biguanide, metabolizes into cycloguanil, an anti-malaria agent that inhibits plasmodium's DNA and protein synthesis.