Antiparasitics

Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) is a agent that combats protozoan infections. Dimetridazole is a nitroimidazole class drug.

HAT-IN-8 (Compound 38), a blood-brain barrier-permeable inhibitor of Trypanosoma brucei with an EC50 of 0.18 μM, is utilized in the study of Human African

Sulfachloropyrazine sodium(Sulfachloropyrazine) is an antiprotozoal,with antibacterial and anticoccidial effects

Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.

Sulfaquinoxaline (Sulfabenzpyrazine) is an antiprotozoal agent.

Satranidazole is an antimicrobial agent that falls under the category of synthetic nitroimidazoles. It is derived from chemical synthesis and is designed to combat infections caused by specific organisms. The mode of action involves the reduction of the nitro group within the organism, creating reactive intermediates that disrupt DNA synthesis and lead to cell death. This mode of action is notably effective against protozoal infections and anaerobic bacterial infections. Satranidazole's applications primarily include the treatment of parasitic diseases such as amebiasis and giardiasis, and it is particularly effective in addressing anaerobic bacterial infections often encountered in clinical settings. Due to its targeted mechanism, Satranidazole is valuable in treating conditions where conventional antibiotics might be less effective. Its use in therapeutics highlights the importance of precise molecular intervention in the realm of infectious diseases. Researchers and practitioners utilize Satranidazole for its specific activity and efficacy in treating difficult-to-manage infections.

Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).

Impurity Atorvastatin EP Impurity D Applications O-Methyl Atovaquone (Atorvastatin EP Impurity D) is a Atovaquone derivative that shows protozoacidal activity against Plasmodium falciparum. References Danoun, S., et. al.: Heterocycl. Commun., 5, 343 (1999)

Oxibendazole is a benzimidazole anthelmintic with action on microtubule formation in parasitic worms and is used for treating roundworms, strongyles, and pinworms in horses and pets.

(+)-Isopulegol is a monoterpenoid from Mentha canadensis L.

Amitraz (NSC 324552): white monoclinic crystals, mp 86-87°C, water-insoluble, used as acaricide and in canine demodectic mange.

MED6-189, an analog of kalihinol, disrupts the apicoplast functions and vesicular transport in the malignant malaria parasite (P. falciparum, IC50 < 50 nM). The compound specifically targets the apicoplast, which is a non-photosynthetic plastid essential for isoprenoid synthesis, found in most apicomplexan parasites.

ZY-19489: Antimalarial, potential single-dose cure, FDA orphan drug status.

Cysteine protease inhibitor-3 (Compound 15), a cysteine protease inhibitor, exhibits anti-plasmodial activity, effectively inhibiting Pf3D7 (IC50 = 0.74 μM),

Applications Pseurotin A shows antiparasitic and anticancer activity. It exhibits inhibition towards IgE (immunoglobin E) production. References Martinez-Luis, S. et al.: Nat. Prod. Comm., 7, 165 (2012); Bioorg. Med. Chem. Lett., 19, 1457 (2009);

Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.

Sulfadiazine sodium (Sulfadiazin-natrium) is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative.

Applications Aminorex is a metabolite of Levamisole (L331100). Aminorex is an anorectic stimulant drug of the 2-amino-5-aryl oxazoline class. Aminorex has been shown to have locomotor stimulant effects similar to Methamphetamine (M258795). References Poos, G., et al.: J. Med. Chem., 6, 266 (1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),