Antiparasitics

Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease.

UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).

Diethyltoluamide (DEET) is the most general active composition in insect repellents.

Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.

Nifuratel (SAP 113) is a local antiprotozoal and antifungal agent that may also be given orally.

Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence.

TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].

Diloxanide furoate treats mild intestinal Amebiasis and is preferred for asymptomatic cyst carriers.

Applications Farnesal is a reagent in the synthesis of farnesylpyrophosphate analogues which acts as bisubstrate inhibitors of protein farnesyltransferase and has antiparasitics properties. References Duez, S. et al.: Bioorg. Med. Chem., 18, 543 (2010);

Compound 31 (compound 7k) is an orally active inhibitor of Plasmodium falciparum aspartic protease, plasmepsin X (PMX), with antimalarial properties [1].

Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.

Applications 3-Hydroxy Niclosamide is a metabolite of Niclosamide(N395500) which is used as an anthelmintic drug (Cestodes). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),

Anti-malarial quinine analogue; effective against Covid-19 infection in vitro

Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.

Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitor

Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Stability Hygroscopic, Temperature Sensitive Applications Ivermectin B1 Aglycon is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178

Fexinidazole, an antiparasitic, targets T. cruzi, T. foetus, T. vaginalis, E. histolytica, T. brucei, L. donovani. Active forms: sulfoxide, sulfone.

Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia.

Pirimiphos-methyl: organophosphorus insecticide/acaricide; inhibits AChE; controls beetles, moths, weevils in stored grains.

SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).

CCOE-5 is a chalcone derivative with antimalarial activity, exhibiting an IC50 of 1.4 μg/mL against P. falciparum (3D7) and an IC50 of less than 5 μg/mL against P. falciparum (INDO). CCOE-5 shows potential for research in the anti-infective domain.

Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen

CpCDPK1/TgCDPK1-IN-2 is a dual inhibitor of CpCDPK1 and TgCDPK1 with IC50 values of 12 and 5 nM for CpCDPK1 and TgCDPK1, respectively.CpCDPK1/TgCDPK1-IN-2 can

Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and

Clopidol (WR-61112) is a very effective anticoccidial agent used in poultry.

Applications N-Didestethyl Chloroquine-d4 Phthalimide is an intermediate in the synthesis of Hydroxychloroquine-d4 Sulfate, which is an antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product. References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),

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SpdSyn binder-1 weakly inhibits malaria by binding to Plasmodium falciparum's spermidine synthase. Used for research.

Applications The major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product. References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),

4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a is a semi-synthetic derivative of avermectin, which is a naturally occurring compound isolated from the fermentation broth of the soil bacterium *Streptomyces avermitilis*. This compound exhibits potent antiparasitic activity by targeting the glutamate-gated chloride channels in the nervous systems of parasitic organisms. By binding and activating these channels, it increases the permeability of the cell membrane to chloride ions, resulting in paralysis and death of the parasite. The compound is primarily used to control a variety of parasitic worms and arthropods in both agricultural and veterinary contexts. Its specificity for invertebrate nerve cells over those of vertebrates makes it particularly effective with minimal toxicity to the host species. This precision in action helps maintain ecological balance while preserving host health. It is a critical tool in managing parasitic resistance, providing a reliable option for controlling infestations that are prone to adapt to other treatment strategies.

Antiparasitic Agent-20 (Compound 1p) exhibits broad-spectrum activity as a parasitic inhibitor, demonstrating efficacy against T.

Robenidine hydrochloride (Robenidine Hydrochoride) is an anticoccidial agent mainly used in poultry.

Decoquinate (Deccox) is a coccidiostat for poultry.

Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.

Compound 42 (Compound 2), an antimalarial agent, effectively inhibits Plasmodium falciparum during the asexual blood stages (IC 50 <0.5μM) and gametocytes (IC 50 is 0.14 μM).

Sulfadoxine (Sulphadoxine) is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial

Ferrocene, a crucial structural core in bioorganometallic chemistry, is renowned for its intrinsic stability, excellent oxygen reduction capabilities, and low toxicity. It also exhibits antimalarial and anticancer properties.

Ronidazole (Ronidazol) is an antiprotozoal and antimicrobial agent used mainly in veterinary practice.

Eprinomectin (MK-397) is an avermectin with anthelmintic and insecticidal activities.

Piperaquine tetraphosphate tetrahydrate is a potent anti-parasites agent.

BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.

Antitrypanosomal agent 14 (Compound 1), a potent T.

Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.

MMV688533 has antimalarial activity.

Applications Hydroxychloroquine Dimer is an impurity of the drug Hydroxychloroquine (H916900), an antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product. References Yarden, Y., et al.: Nature, 323, 226 (1986); Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989); Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002); Card, J., et al.: Toxicol. Sci., 75, 169 (2003)

Isopimpinellin (4,9-Dimethoxypsoralen) is a natural product isolated from the roots of Pimpinella saxifrage with antiviral and antileishmanial activity.

Insecticidal agent 2 (example 2) is an effective pesticide that significantly inhibits pest growth [1].

NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.

Niridazole (Ambilhar) is an antiparasitic compound belonging to nitroimidazoles.

Thiabendazole is a benzimidazole anthelmintic with action on parasitic worms by inhibiting energy metabolism and is used for treating infections like threadworm and roundworm.

Hexythiazox is a mite growth regulator and a thiazolidine based acaricide that has long-lasting effects against many kinds of mites and is applied at any stage

Stability Moisture Sensitive Applications N-(2-Benzoyl-4-chlorophenyl)formamide is used as a reagent in the synthesis of 2-aminoindole compounds that can be used as antimalarial agents. References Mazitschek, R., et al.: PCT Int. Appl. WO 2011053697 A1 20110505. May 5, 2011

Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in

Oxantel Pamoate (Oxantel embonate) is used as an Antinematodal agent.

Applications trans-4-(4-Chlorophenyl)cyclohexanecarboxylic Acid is an impurity of Atovaquone (A793500), which is a hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport and possess antipneumocystic activity. References Hudson, A.T., et al.: Drugs Exp. Clin. Res., 17, 427 (1991), Fry, M., et al.: Biochem. Pharmacol., 43, 1545 (1992), El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998),

Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent.

Naturally produced by the soil bacterium Streptomyces avermitili, Ivermectin is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, research indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins. Ivermectin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.