Steroids

Natural glycoside

Pregnenolone is a steroidal hormone precursor, which is synthesized from cholesterol in the mitochondria of adrenal glands and other tissues. Its mode of action involves serving as a precursor for other critical steroid hormones, including progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As a neurosteroid, it plays a significant role in modulating synaptic function and neurogenesis. Pregnenolone is utilized in research to understand hormone synthesis pathways and its effects on cognitive functions, memory enhancement, and neuroprotection. It is involved in studies focusing on stress response, aging, and neurological conditions such as Alzheimer's disease, due to its impact on neuroplasticity and cell signaling pathways. It is also being examined for its potential role in mood regulation and the modulation of inflammatory processes.

Lactone

Taurochenodeoxycholate-3-sulfate (TCDCS) is a top-ranking classifier on the receiver operating characteristic curve for severe and non-severe COVID-19 patients.

Dihydrowithaferin A, a withanolide from Withania somnifera, inhibits AChE and may reduce tumor growth.

Applications Metabolite of 5α-Androst-16-en-3β-ol References Gower, D., et al.: J. Steroid Biochem. Mol. Biol., 63, 81 (1997), Zorko, M., et al.: Steroids, 65, 46 (2000), Diel, P., et al.: Toxicol. Lett., 169, 64 (2007),

Sterol

Applications A labelled metabolite of 17β-Estradiol. References Cushman, M., et al.: J. Med. Chem., 38, 2041 (1995), D’Amato, R.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 3964 (1994), Forsis, T., et al.: Nature, 368, 237 (1994)

Applications Testosterone Palmitate-d31 is the labeled analogue of Testosterone Palmitate (T155140) which is found in male serum. References Addo, S.B., et. al.: Steroid, 54, 257 (1989)