Steroids

Pregna-4,8-diene-3,20-dione is a synthetic corticosteroid, which is an analog of naturally occurring hormones produced by the adrenal cortex. This compound is synthesized through complex chemical pathways utilizing steroidal intermediates to produce a substance with potent biological activity. The mode of action of Pregna-4,8-diene-3,20-dione involves its ability to alter the transcription of certain genes by binding to glucocorticoid receptors. This interaction induces the synthesis of proteins that inhibit the inflammatory response and suppress the immune system. Pregna-4,8-diene-3,20-dione is utilized in a variety of clinical applications, primarily for its anti-inflammatory and immunosuppressive properties. It is commonly employed in the treatment of conditions such as arthritis, allergic reactions, and autoimmune disorders. Additionally, it may be used as a component in combination therapies to reduce inflammation in more severe medical cases. Researchers continue to explore its potential in various other therapeutic areas, aiming to exploit its molecular characteristics to address complex medical challenges.

Estrone-3-Glucuronide sodium hydrate is the main metabolite of estrone, serving as a biological marker for gender identification in Andrias davidianus.

Applications Mometasone-d5 is the Isotope labelled analogue of Mometasone (M489995), a potent topical corticosteroid. Mometasone has potent antiinflammatory activity and is used in the treatment of dermatological disorders. References Schulz, M. et al.: Pharm. Zeit., 139, 28 (1994); Prakash, A. et al.: Drugs, 55, 145 (1998);

Cholestenone ((+)-4-Cholesten-3-one) is an intestinal metabolite of Cholesterol. It shows an anti-obesity effect on animals.

Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents.

Applications A metabolite of catecholamines. References Canfell, P., et al.: Clin. Chem., 32, 222 (1986), Nunez, C., et al.: Eur. J .Clin. Chem. Clin. Biochem., 32, 461 (1994), Weise, M., et al.: J. Clin. Endocrinol. Metab., 87, 1955 (2002),

Applications Flunisolide is a synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chu, N.I., et al.: Drug Metab. Dispos., 7, 81 (1979), Pakes, G.E., et al.: Drugs, 19, 397 (1980)

Asparanin B is a natural compound, which is a specialized saponin derived from the roots of asparagus plants, specifically from Asparagus officinalis. It exerts its effects through the modulation of cellular pathways, including the inhibition of cell proliferation, induction of apoptosis, and disruption of key signaling mechanisms involved in cancer development and progression. As a result, Asparanin B is being studied for its potential anticancer properties. In experimental settings, Asparanin B has demonstrated promising outcomes in the reduction of tumor growth and the enhancement of chemotherapy efficacy. Its mode of action encompasses the regulation of crucial molecules such as caspases and cyclins, which are integral to the cell cycle and apoptotic processes. Researchers are exploring its applications in oncology, aiming to harness its biological activity for therapeutic interventions. Furthermore, the minimal cytotoxicity observed in normal cells has spurred interest in its development as a targeted cancer therapy. Ongoing investigations continue to elucidate its full potential and mechanisms, shedding light on the diverse pharmacological applications of plant-derived compounds in modern medicine.

β-Sitosterol β-D-glucoside is a phytosterol glycoside, which is primarily derived from plant sources such as fruits, vegetables, nuts, and seeds. As a natural component of plant cell membranes, it exhibits bioactive properties. The compound functions by modulating cholesterol metabolism and has anti-inflammatory, immunomodulatory, and antioxidant effects. It achieves this by interfering with the absorption of cholesterol in the intestines and modulating the activity of enzymes involved in its metabolism. The uses and applications of β-Sitosterol β-D-glucoside are extensive in the field of medicinal chemistry and health sciences. It is investigated for its potential in reducing the risk of cardiovascular diseases by lowering LDL cholesterol levels. Additionally, it shows promise in cancer research as it may inhibit the growth of cancer cells through various biochemical pathways. The anti-inflammatory properties make it a candidate for studies related to autoimmune and inflammatory conditions. Researchers are also exploring its role in enhancing immune response and its potential therapeutic effects in conditions such as benign prostatic hyperplasia.

Digitalis glycoside

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications A metabolite of Spironolactone. References Gochman, N., et al.: J. Pharmacol. Exp. Ther., 135, 312 (1962), Tori, K., et al.: Steroids, 4, 713 (1964), Solymoss, B., et al.: Toxicol. Appli. Pharmacol., 18, 586 (1971),

Applications Labelled Melengestrol acetate (M215352). Orally active progestational steroid. Progestogen; growth promotant. References Patton, M., et al.: Zoo Biol., 26, 311(2007), Sellin, M., et al.: Environ. Toxicol. Chem., 28, 2443 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Sanseverino, J., et al.: Toxicol. Sci., 107, 122 (2009),

Applications An antiestrogen and antineoplastic. Nonsteroidal antiestrogen structurally similar to Tamoxifen. Toremifine has has been shown to reduce Ebola infection in rodents (3). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kallio, S., et al.: Cancer Chemother. Pharmacol., 17, 103 (1986), Valavaara, R., et al.: Eur. J. Cancer Clin. Oncol., 24, 785 (1988); (3) Chem. and Eng. News p9, July 4 (2016)

Impurity Fluticasone USP Related Compound B Applications An impurity of Fluticasone Propionate (F599500), a derivative of Flumethasone (F455000). An antiallergic; anti-asthmatic; anti-inflammatory. Fluticasone USP Related Compound B. References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009), Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)

Applications 5-Alpha-Dihydrotestosterone (2,2,4,4-D4, 98%) 95% Chemical Purity (cas# 5295-66-9) is a useful research chemical.

Nandrolone phenylpropionate (Nandrolone phenpropionate) is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis

Finasteride is used as a inhibitor of steroid 5-a-reductase, antiandrogen, an intracellular enzyme that converts the androgen testosterone into 5α dihydrotestosterone. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Aminosteroid, competitive neuromuscular blocker.

Stability Light Sensitive, Temperature Sensitive Applications A metabolite of all-trans Retinoic acid (R250200). References Idres, N., et al.: Cancer Res., 61, 700 (2001), Taimi, M., et al.: J. Biol. Chem., 279, 77 (2004), Vermot, J., et al.: Science, 308, 563 (2005),

Phytoestrogen with anti-cancer properties

Natural alkaloid

Natural alkaloid

Applications A biologically active labelled metabolite of Desogestrel. References Croxatto, H.B., et al.: Hum. Reprod., 14, 976 (1999), Edwards, J.E., et al.: Brit. J. Fam. Plan., 24, 3 (1999),

Applications Unlabeled Taurohyodeoxycholic Acid (T007900) is a bile acid which stimulates the flow of bile salts, for potential treatment of Irritable Bile Syndrome. References Gnewuch, C., et al.: World J. Gastroenterol., 15, 3134 (2009), Yu, B., et al.: J. Nat. Prod., 72, 24 (2009), Lim, S., et al.: Int. J. Cancer, 126, 1582 (2010),

Applications A synthetic adrenocorticosteroid that acts as an anti-inflammatory and anti-pruritic agents. It is used as a topical for the treatment of dermatologic disorders such as atopic dermatitis and psoriasis. References Mason, J. et al.: Br. J. Dermatol., 146, 351 (2002); Sears, H.W. et al.: Clin. Therap., 19, 710 (1997); Otomo, Y.Z. et al.: Nip. Yakur. Zas., 78, 647 (1981);

Applications 16-Hydroxycorticosterone 20-Hydroxy-21-Acid is an oxidized derivative of corticosterone (C695700), an intermediate in the biosynthesis of aldosterone (A514700), isolated from the adrenal cortex. It is also a pheramone that triggers natural behaviour in the vomeronasal system of mice. References Schmidt, M., et al.: Endocrinol., 150, 2709 (2009), Bailey, M., et al.: J. Immunol., 182, 7888 (2009), Brunton, P., et al.: J. Neurosci., 29, 6449 (2009), Pruett, S., et al.: Toxicol. Sci., 109, 265 (2009); Fu, X., et al.: Cell, 163, 313 (2015)

Applications Nandrolone Benzoate-d5 is the isotope analog of Nandrolone Benzoate. Nandrolone Benzoate is a steroid that has effect on gondatropin and muscles, which is derived from Nandrolone (an anabolic steroid). References Lerner, L.J., et al.: Endocrinology, 64, 1010 (1959), Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990), Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008),

Applications Isotope labelled intermediate in the synthesis of Dexamethasone (D298800), a glucocorticoid anti-inflammatory agent. References Liu, Y., et al.: Anal. Bioanal. Chem., 395, 591 (2009), Rodgers, A., et al.: Chem. Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

7α-Hydroxycholesterol is a cholesterol oxide formed by both enzymatic and non-enzymatic oxidation. It can be used as a biomarker for lipid peroxidation.

The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro

Applications This is a controlled substance (anabolic steroid). Anabolic. References De Marchi, et al.: Arzneim.-Forsch., 23, 1583 (1973), Masse, R., et al.: Anal. Chim. Acta, 247, 211 (1991),

Lactone

Applications A labelled derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory. References Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)

Applications Isotope Labelled 17β-Estradiol 3-O-Sulfate is a neuroactive steroid used in the studies of human recombinant p1 γ-aminobutyric acid type C (GABAC) recptors. References Li, W.J., et al.: J. Pharmacol. Exp. Therp., 323, 236 (2007); Schneider, C., et al.: Steroids., 69, 245 (2004);

DHED is a neuroactive steroid precursor, specifically a bioprecursor prodrug of estradiol, which is derived from chemical synthesis pathways. It is unique in its targeted mode of action, as it selectively converts to the active hormone estradiol within the brain via enzymatic processes that occur in situ. This specificity is facilitated by 17β-hydroxysteroid dehydrogenase type 1, which catalyzes the conversion of DHED to estradiol exclusively in the brain, minimizing peripheral estrogenic effects. The principal applications of DHED are centered on addressing neurological and psychological disorders that are associated with reduced estrogen levels in the brain, including neurodegenerative diseases like Alzheimer's, depression, and cognitive decline in post-menopausal conditions. The ability of DHED to act centrally without influencing systemic estrogen levels bears potential for therapeutic strategies aimed at enhancing brain function while circumventing systemic side effects traditionally linked with estrogen therapy. This targeted delivery approach paves the way for advancements in treating neurologically relevant conditions with greater precision and reduced risk of peripheral side effects.

Glycodeoxycholate Sodium, a secondary bile acid, triggers hepatocyte apoptosis via DNA endonuclease cleavage.