Steroids

Natural alkaloid

Applications 5-Androstenediol is a steroid androgen metabolite of Testosterone (T155000), the principal hormone of the testes, produced by the interstitial cells. References Miller, M., et al.: Steroids., 78, 15 (2013); Baker, M.E., et al.: Steroids., 77, 1192 (2012); Ronis, M.J.J. et al.: Comp. Biochem. Physiol.-C: Pharmacol. Toxicol. Endocrinol., 121C, 221 (1998);

Applications Labelled Fluticasone 17β-Carboxylic Acid Propionate (F599495). An impurity formed in the synthesis of Fluticasone propionate (F599500). References Phillips, G., et al.: J. Med. Chem., 37, 3717 (1994),

Stability Hygroscopic Applications It is one of the mono-hydroxylated metabolite of Stanozolol (S684500), an internal standard in doping analysis. References Chung, B., et al.: J. Anal. Toxicol., 14, 91 (1990), Schanzer, W., et al.: J. Steroid Biochem., 36, 153 (1990), Phillis, B., et al.: Eur. J. Pharmacol., 398, 263 (2000)

1-Dehydroepiandrosterone is a steroid hormone and a metabolic intermediate in the biosynthesis of androgen and estrogen sex steroids, which is derived from cholesterol in the adrenal glands, gonads, and brain. Acting primarily as a prohormone, it facilitates the synthesis of active steroid hormones by serving as a precursor molecule that undergoes enzymatic conversion into potent androgens like testosterone and dihydrotestosterone, as well as estrogens such as estradiol within peripheral tissues. The primary function of 1-Dehydroepiandrosterone is to assist in and regulate the body's physiological processes by modulating sex hormone levels. This capability makes it instrumental in research focused on aging, hormonal imbalances, and disorders related to androgen deficiency. In terms of applications, it is extensively utilized in studies exploring its potential roles in influencing mood, cognition, immune function, and metabolic processes. Additionally, owing to its role in neurosteroid synthesis, it is being investigated for its potential impact on neurological conditions. Understanding the pathways and impacts of 1-Dehydroepiandrosterone provides valuable insights in biochemistry and clinical endocrinology.

Stability Hygroscopic Applications beta-Estradiol 17-(beta-D-glucuronide) sodium salt is a glucocorticosteroid analog.

Sterol

Applications 6β-Hydroxy Betamethasone can be used as analyte in analytical study for detecting betamethasone metabolites in human urine using liquid chromatography coupled to tandem mass spectrometry. References Matabosch, X., et al.: Drug Testing and Analysis, 7, 663-672 (2015)

Stability Hygroscopic Applications Tixocortol is an anti-inflammatory agent. Tixocortol is used in fluorescent chemoaffinity labeling. References Torossian, D.R., et al.: Arzneim.-Forsch., 31, 453 (1981),

Applications Labelled Campesterol (C155360). A phytosterol, which may inhibit the intestinal absorption of cholesterol. References Fransen, H., et al.: J. Nut., 140, 1062 (2010), Kojoma, M., et al.: Plant Biotechnol., 27, 59 (2010), Orozco-Solano, M., et al.: J. Agric. Food Chem., 58, 7539 (2010),

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications The major metabolite of Deflazacort. References Bernareggi, A., et al.: J. Pharma. Biomed. Anal., 5, 177-81 (1987), Assandri, A., et al.: Xenobiotica, 13(3), 185 (1983), Martinelli, E., et al.: Drug Metab. Dispos., 7, 335 (1979),

Applications A Labelled metabolite of Testosterone (T155000). It is a promising androgen for male hormonal contraception.CONTROLLED SUBSTANCE References Glass, A., et al.: J. Clin. Endocrinol. Metab., 45, 1211 (1977), Behre, H., et al.: Eur. J. Endocrinol., 140, 414 (1999), Nieschlag, E., et al.: Steroids, 68, 965 (2003), Wang, C., et al.: J. Clin. Endocrinol. Metab., 91, 460 (2006),

Applications Synthetic anabolic; epimeric with Calusterone (C148900). Controlled substance (anabolic steroid). References Horn, H., et al.: Br. J. Cancer, 33, 336 (1976), Zumoff, B., et al.: J. Clin. Endocrinol. Metab., 44(6), 1203 (1977),

Applications The R-enantiomer of nonsteroidal selective androgen receptor modulator (SARM) Ostarine (O703500).

Deoxycorticosterone, an adrenal steroid, is an aldosterone precursor with mineralocorticoid effects.

Impurity Mometasone Furoate Impurity N / Mometasone EP Impurity N Applications Icomethasone 21-Mesylate is a derivative of Icomethasone (I164100), used in the preparation of Mometasone (M489995).

Stability Temperature Sensitive Applications 6-Defluro-6-oxo-fluticasone Propionate is a derivative of Flumethasone (F455000), a glucocorticoid, anti-inflammatory. References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009),

Natural glycoside

Pennogenin 3-O-beta-chacotrioside from Paris polyphylla fights colorectal cancer, boosting autophagy proteins LC3 and Beclin-1.

Applications (3β)-Allopregnanolone Sulfate is the sulfate conjugate of (3β)-Allopregnanolone, a metabolite of progesterone and a potent inhibitory modulator of GABAA receptors. References Li, P. et al.: Mol. Pharmacol., 77, 539 (2010); El-Etr, M. et al.: Brain Res., 790, 334 (1998); Park-Chung, M. et al.: Brain Res., 830, 72 (1999);

Applications Desoxymetasone-D5 is a labelled analogue of Desoxymetasone (D296970). Desoxymetasone is a fluorinated corticosteroid that is structurally related to Dexamethasone (D298800), and is used as a topical cream to treat eczema. References Heel, R., et al.: Drugs, 16, 302 (1978); Henry, M., et al.: Curr. Med. Res. Opin., 6, 502 (1980); Sehgal, Int. J. Derm., 15, 770 (1976)

Applications 6β-Hydroxy Dutasteride is a hydroxylated derivative of Dutasteride (D735000).

Applications 5beta-Androstan-3alpha-ol-11,17-dione-9,12,12,16,16-d5 is a useful isotopically labeled compound of 11-Oxo Etiocholanolone (O856650)

Natural glycoside

Stability Hygroscopic Applications 1,2-Dihydro Dexamethasone Phosphate Disodium Salt is an impurity of Dexamethasone Phosphate (D298835). References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),

Telocinobufagin (TCB), a bufadienolide extracted from Bufo paracnemis parotoid glands, shows a reversible local anesthetic action, similar to BUPI, however, without cardiac toxicity in vitro.

Applications 4-Pregnen-17alpha,21-diol-3,20-dione-21,21-d2 (CAS# 1271728-08-5) is a useful isotopically labeled research compound.

Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Alicyclic ketone

Applications Diamethazine is an C17-alkylated, anabolic-androgenic steroid, that exhibits similar effects to Superdrol (M226010). References Orlandi, F., et al.: Adv. Hepatol. Trans. Int. Symp. Int. Assoc. Study Liver., 109 (1965); Shakoori, A. R, et al.: Proceeding. Congress. Zool., 24, 1 (2004);

Applications Toosendanin is a triterpenoid derivative and a novel agonist of L-type Ca2+ channels in neonatal rat ventricular cells (1,2,3). References (1) Li, M.F., et al.: Euro. J. Pharmacol., 501, 71 (2004) (2) Nakai, Y., et al.: Bioorg. Med. Chem., 18, 1280 (2010) (3) Zhang, B., et al.: Invest. New. Drugs., 23, 547 (2005)

Natural glycoside

Applications Labelled analogue of 17-epi-Nandrolone, an epimer of the anabolic steroid Nandralone (N315000). Controlled substance (anabolic steroid). References Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990); Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991); Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007);