Steroids

Liriopesides B (Nolinospiroside F) exhibited potential anticancer activity against human ovarian cancer A2780 cells.

Applications A normal mammalian metabolite of Cortisone (C696500). References Schneider, et al.: J. Biol. Chem., 183, 365 (1950), Barkemeyer, et al.: Appl. Microbiol., 8, 237 (1960),

Impurity Beclomethasone Dipropionate EP Impurity I Applications (16β)-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4,9(11)-triene-3,20-dione (Beclomethasone Dipropionate EP Impurity I) is an impurity of Beclomethasone (B131000), a glucocorticoid. Used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical). References Malfitan, V.A., et al.: Clin. Ther., 4, 472 (1982), Rao, M., et al.: J. Asthma, 19, 21 (1982), Small, P., et al.: Ann. Allergy, 49, 127 (1982), Brogden, R.N., et al.: Drugs, 28, 99 (1984),

Diosgenin, a steroidal saponin present in fenugreek (Trigonella foenum graecum) and other plants, has been shown to suppress inflammation, inhibit proliferation, and induce apoptosis in a variety of tumor cells; it suppresses proliferation, inhibits invasion, and suppresses osteoclastogenesis through inhibition of NF-kappaB-regulated gene expression and enhances apoptosis induced by cytokines and chemotherapeutic agents.

Stability Very Hygroscopic Applications Labelled Glycochenodeoxycholic Acid (G641255). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. References Ollila, F., et al.: Langmuir, 17, 7107 (2001), Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004), Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005),

Impurity Beclomethasone Dipropionate EP Impurity L Applications 1,2-Dihydro Beclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity L) is an impurity of Beclomethasone Dipropionate (B131030).

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Lactone

Applications Gestodene-2,2,4,6,6,10-d6 (CAS# 1542211-40-4) is a useful isotopically labeled research compound.

Impurity Estriol EP Impurity H Applications 16α-Hydroxy Estrone (Estriol EP Impurity H) is a major metabolite of Estradiol. References Fishman, H.G, et al.: Biochemistry, 8, 4304 (1969), Ryan, Sugar, J., et al.: J. Clin. Endocrinol. Metab., 50, 137 (1980), Numazawa, M., et al.: Steroids, 38, 149 (1981), Travis, R., et al.: Breast Cancer Res., 5, 239 (2003),

Stability Temperature Sensitive Applications Anabolic steroid. Androgen.Controlled substance. References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),

Ergosterol (Provitamin D2) is a steroid extracted from Ganoderma lucidum cystocarp.

Applications 20β-Dihydro Pregnenolone is a metabolite of Pregnenolone (P712200). References Purdy, R., et al.: J. Med. Chem., 33, 1572 (1990), Bixo, M., et al.: Brain Res., 764, 173 (1997), Huang, X., et al.: J. Biol. Chem., 275, 29452 (2000),

Applications A metabolite of Digoxin (Dx) (D446575). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Fujii, Y., et al.: Clin. Chem., 37, 476 (1991), Salphati, L., et al.: Xenobiotica, 29, 171 (1999), Song, S., et al.: Drug Metab. Dispos., 27, 689 (1999),

Natural alkaloid

Formononetin is a naturally occurring isoflavone, which is a type of phytoestrogen found predominantly in legumes like red clover and other related plant species. It is a secondary metabolite that influences various biological processes by interacting with estrogen receptors. Formononetin acts primarily by mimicking or modulating the activity of natural estrogens within the body, binding to estrogen receptors and influencing gene expression and cellular responses. One of the principal applications of Formononetin is in the study of its potential therapeutic effects, including its role in modulating hormonal balance and alleviating menopausal symptoms due to its estrogen-like activity. Additionally, it has garnered interest for its potential in cancer research, particularly concerning estrogen-responsive cancers, and its cardiovascular health benefits. Its antioxidant and anti-inflammatory properties further expand its possible uses in managing oxidative stress and inflammatory conditions. Scientists continue to explore how Formononetin can contribute to improving health outcomes through its complex biochemical interactions and potential in pharmaceutical development.

Applications 16α-Hydroxydehydroepiandrosterone, is the metabolite of Dehydroepiandrosterone (DHEA) (D229585), which is a major secretory steroidal product of the adrenal gland. References Yahara, M., et al.: J. Toxicol. Sci., 2, 161 (1977), Morales, A.J., et al.: J. Clin. Endocrinol. Metab., 78, 1360 (1994), Ebeling, P., et al.: Lancet, 343, 1479 (1994),

Sitostenone, an antioxidant, treats androgen-related diseases, such as benign prostatic hyperplasia.

Estrone sulfate sodium, an inactive estrogen ester, transforms into estrone via steroid sulfatase. It's studied for targeting polypeptide transporters.

Natural glycoside

Protodioscin (Furostanol I) is a major steroidal saponin in dioscoreae rhizome, with anti-hyperlipidemia, anti-cancer properties.

Applications 3β-Dihydroxy-19-norandrost-5(10)-ene is an intermediate in the synthesis of 3β,17β-Dihydroxy-19-norandrost-5(10)-ene (D453800), which is a metabolite of Androstenedione. A novel 19-norsteroid, from androstenedione and 19-hydroxyandrostenedione by cultured porcine granulosa cells is reported for the first time. References Haarbo, J., et al.: Clin. Physiol., 11, 331 (1991), Krebs-Smith, S., et al.: Eur. J. Clin. Nutr., 54, 281(2000), Rasmussen, B., et al.: J. Clin. Endocrinol. Metab., 85, 55 (2000),

Methyl protogracillin is a natural product from Dioscorea collettii var. hypoglauca with anti-cancer activity.

Applications A labelled metabolite in human hepatic bile. A lithocholic acid analog that inhibit sialyltransferase. References Ishikawa, H., et al.: J. Lipid. Res., 40, 1920 (1999), Gustafsson, U., et al.: Eur. J. Clin. Invest., 30, 1099 (2000), Gowda, G., et al.: Lipids, 41, 591 (2006), Lindon, J., et al.: Pharm. Res., 23, 1075 (2006),

Gamabufotalin, a Chansu bufadienolide, treats COX-2 diseases and cancer with high stability and low side effects.

Ketone alcohol

Applications 7β-Hydroxydehydroepiandrosterone (7β-OH DHEA) is the main metabolite of Dehydroepiandrosterone (DHEA) (D229585). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Smuga, D.A., et al.: Steroids, 75, 1146 (2010),

Impurity Fluocinolone Acetonide EP Impurity C Applications Fluocinolone, is a medication, used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin condition. It is also a derivative of Fluocinolone Acetonide (F455800). References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),

Oxygen-heterocyclic compound

Stability Light Sensitive Applications 3-(4-Hydroxyphenyl)-1,1,3-trimethyl-5-indanol is a compound derived from Bisphenol A (B519495), a chemical used in the manufacturing of polycarbonate plastics that has effects on reproductive health, body weight, and plasma LH levels in female Sprague-Dawley rats. References Calafat, A., et al.: Environ. Health Persp., 116, 39 (2008); Rubin, B., et al.: Environ. Health Persp., 109, 675 (2001)

Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.

Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga hairy roots.

Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.

Applications A labelled metabolite of Norgestimate. References Phillips, A., et al.: Steroids, 55, 373 (1990)

Natural glycoside

Applications 4-Methoxyestrone-1,2,16,16-d4 is a useful isotopically labeled compound of 4-Methoxy Estrone (M226135)

Natural alkaloid

Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.

Arenobufagin is a potent Na + /K + pump inhibitor, and is also a specific inhibitor of VEGF-mediated angiogenesis. Arenobufagin has antineoplastic effect that involves cross talk between apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway.