Steroids

Applications Labelled Cyproterone Acetate. The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne. References Moltz, L., et al.: Contraception, 21, 393 (1980), Hammerstein, J., et al.: J. Steroid Biochem., 29, 591 (1983)

Applications Labelled myo-Inositol Trispyrophosphate hexasodium (I666020). A novel membrane-permeant allosteric effector of hemoglobin (Hb), enhances the regulated oxygen release capacity of red blood cells, thus counteracting the effects of hypoxia in diseases such as cancer and cardiovascular ailments. References Duarte,C.D. et al.: Chembiochem., 11, 2543 (2010); Biolo, A. et al.: Proc. Nat. Acad. Sci. U.S.A., 106, 1926 (2009);

Applications Pyrethrin is a pesticide most commonly used around homes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hudson, N.L., et. al.: Am. J. Ind. Med., 57, 15 (2014)

Applications A metabolite of Androsterone (A637535). References Goldzieher, J., et al.: J. Clin. Endocrinol. Metab., 29, 171 (1969), Parr, M., et al.: Steroids, 72, 545 (2007), Lippi, G., et al.: Clin. Biochem., 42, 904 (2009),

Triamcinolone acetonide suppresses allergic, inflammatory, and immune responses. Intravitreal administration of triamcinolone acetonide is used against diabetic macular edema. It is also used to relieve the discomfort of mouth sores. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/

9,10-Secocholesta-5,7,10(19)-trien-3beta-ol is a secosteroid compound, which is predominantly derived from the photochemical conversion of 7-dehydrocholesterol in the skin upon exposure to ultraviolet B radiation. This compound undergoes a series of hepatic and renal hydroxylations to form active vitamin D metabolites, such as calcitriol. These active forms modulate calcium and phosphate homeostasis through a nuclear receptor-mediated mechanism that governs gene expression relevant to mineral metabolism. The primary application of 9,10-Secocholesta-5,7,10(19)-trien-3beta-ol and its derivatives is in the field of endocrinology and metabolism, particularly concerning bone health and the management of disorders such as rickets, osteomalacia, and osteoporosis. Additionally, its role in immune modulation and cell differentiation presents potential therapeutic avenues in immunology and oncology. Understanding the biosynthesis, metabolism, and receptor interactions of this secosteroid is critical for developing advanced therapeutic strategies for calcium-related pathologies and beyond. Its significance extends into nutritional sciences, illuminating the implications of vitamin D deficiency and necessitating advancements in supplementation strategies.

Stability Hygroscopic Applications Equilin 3-Sulfate Sodium Salt, is a metabolite of Equilin (E592800). References Hajdu, A., et al.: Experientia, 27, 956 (1971), Adams, W.P., et al.: J. Pharma. Sci., 68, 986 (1979),

Fusidic acid (Fusidine) is an antibiotic isolated from the fermentation broth of Fusidium coccineum.

Dioscin, a saponin extracted from the root of Polygonatum Zanlanscianense Pamp, can markedly inhibit proliferation of Hela cells, underwent apoptosis in dose- and time-dependent manner.

Lactone

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-O-Acetyl-20-hydroxyecdysone, in bugs/plants, thwarts Aβ42 toxicity, turns harmful Aβ oligomers to safer fibers.

Telocinobufagin, a potent digitalis-like factor, reduces spleen bacteria and boosts survival in immunized mice, showing promise as an immunotherapy for cancer.

Chenodeoxycholic acid (CDCA), a bile acid, usually conjugated with either glycine or taurine, acts as a detergent to solubilize fats for intestinal absorption.

Applications A labelled glucocorticoid. References Hall, E.D., et al.: J. Neurosurg., 76, 13 (1992), Hommes, O.R., et al.: Mult. Scler., 1, 327 (1996), Bracken, M.B., et al.: J. Neurosurg., 89, 699 (1998), Dammers, J.W.H.H., et al.: Brit. Med. J., 319, 884 (1999)

Applications A derivatives of Dexamethasone (D298800), an analog of cortical hormones. References Giesen, E.M., et al.: Molec. Cell. Endocrinol., 22, 153 (1981),

Oleaside A is isolated from Nerium oleander.

Applications Deuterated Ursodeoxcholic Acid. Used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7. References Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986), Poupon, R.E, et al.: N. Engl. J. Med., 324, 1548 (1991), MacKenzie, P., et al.: J. Biol. Chem., 283, 36205 (2008),

Stability Hygroscopic Applications Androsterone (A637535) analogue. A precursors of Testosterone (T155000) and Nandrolone (N315000). References Franke, W., et al.: Clin. Chem., 43, 1262 (1997), Rivier, L., et al.: Chimia, 56, 84 (2002), Leinonen, A., et al.: Steroids, 69, 101 (2004),

3,5,6-trihydroxysitostane is a steroid natural product derived from the fruits of Evodia rutaecarpa.

Applications Dexamethasone Acid Ethyl Ester is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Applications A metabolite of Testosterone (T155000). References Janer, G., et al.: Aquat. Toxicol., 75, 32 ( 2005), Lavado, R., et al.: Steroids, 71, 489 (2006),

Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca.

Glycoursodeoxycholic acid, a secondary bile acid-glycine conjugate, is formed by colonic microbes and found in mammalian bile.

Cholic acid is used as a preservative for food. It is widely used as an intermediate in the manufacture of pharmaceuticals. It finds use in biological research. It helps in detergents to soften biological fats. It helps in preventing and melting gallstones. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Pabulenol is an innovative biopolymer, which is synthesized from renewable plant-based resources through advanced biotechnological methods involving enzymatic polymerization. With its unique molecular structure, Pabulenol exhibits specific mode of action by facilitating biodegradation under ambient conditions, catalyzed by naturally occurring microbes. The polymer’s intrinsic ability to break down into non-toxic byproducts makes it an exceptional choice for sustainable environmental applications. Pabulenol finds extensive use across multiple domains, including agricultural, packaging, and environmental remediation sectors. In agriculture, it acts as a soil conditioner, enhancing nutrient availability and improving soil health. In packaging, its biodegradability addresses ecological concerns associated with traditional plastics. Moreover, it plays a crucial role in environmental remediation by assisting in the breakdown of organic pollutants. The versatility and ecological benefits of Pabulenol position it as a pivotal material in efforts to reduce environmental footprints and promote sustainability.

Applications Bazedoxifene-d4 is a labeled nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic. References van Hoorn, W., et al.: J. Med. Chem., 45, 584 (2002); Neubauer, B., et al.: Cancer Res., 63, 6056 (2003); Yan, X., et al.: Biochemistry, 43, 909 (2004);

Applications Anabolic steroid. Androgen.Controlled substance. References Glass, A., et al.: J. Clin. Endocrinol. Metab., 45, 1211 (1977), Behre, H., et al.: Eur. J. Endocrinol., 140, 414 (1999), Nieschlag, E., et al.: Steroids, 68, 965 (2003), Wang, C., et al.: J. Clin. Endocrinol. Metab., 91, 460 (2006),

Applications 5alpha-Pregnan-3,20-dione-2,2,4,4,17alpha,21,21,21-d8 is a useful isotopically labeled compound of (5α)-Pregnane-3,20-dione (P705150)

Applications A Dexamethasone Dipropionate metabolite. References Civiale, C., et al.: J. Ocul. Pharmacol. Thera., 20, 75 (2004),

Applications A labelled glucocorticoid microemulsion nasal preparation allergy inhibitor rhinitis.This compound is a mixture of diastereomers at the cyclohexyl acetal. References Fukuoka, E., et al.: Chem. Pharm. Bull., 35, 2943 (1987), Schmitt, E., et al.: J. Pharm. Sci., 88, 291 (1999), Hancock, B., et al.: Pharm. Res., 17, 397 (2000), Hogan, S., et al.: Pharm. Res., 18, 112 (2001).

Natural alkaloid