Steroids

Applications A metabolite of Estradiol (E888000). References Ball, P., et al.: Steroids, 33, 563 (1979), Wong, T., et al.: Clin. Chem., 38, 1830 (1992), Xu, X., et al.: J. Clin. Endocrinol. Metab., 84, 3914 (1999), Todorovic, R., et al.: Carcinogenesis, 22, 905 (2001), Travis, R., et al.: Breast Cancer Res., 5, 239 (2003),

Applications Betamethasone 17-Butyrate is an impurity of Clobetasone 17-Butyrate (C583550), an glucocorticoid used for anti-inflammatory purposes.

Applications Isotope labelled 24-Hydroxycholesterol is the main cholesterol elimination product of the brain and was found to be increased in serum of Alzheimer patients. References Kolsch, H., et al.: J. Neural. Transm., 108, 475 (2001); Gamba, P., et al.: Aging. Cell., 10, 403 (2011); Seet, R.C.S., et al.: Free. Rad. Biol. Med., 48, 560 (2010);

Applications Labelled Trenbolone (T719000). Controlled substance (anabolic steroid). References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),

Applications Labelled Cholesterol (C432501). Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones. References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),

Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.

Dihydroformononetin is an isoflavonoid phytoestrogen, which is a type of naturally occurring compound found primarily in leguminous plants. It is derived from plant sources such as red clover and soybeans, known for their rich isoflavone content. This compound undergoes metabolic conversion in plants and potentially in the human body, exerting effects through interactions with estrogen receptors. The mode of action of dihydroformononetin involves binding to estrogen receptors, mimicking estrogenic activity, and potentially influencing pathways related to hormonal balance and cellular processes. It can modulate different cellular pathways and exhibit antioxidant properties, adding to its pharmacological profile. Dihydroformononetin is studied for its applications in health and medicine. Its estrogenic activity makes it a candidate for research in hormone-related conditions such as menopause, osteoporosis, and cardiovascular health. Furthermore, its antioxidant capacity and ability to affect cellular pathways provide additional avenues for exploring anti-inflammatory and anticancer properties. Researchers are particularly interested in its role in modulating signaling pathways, which may have therapeutic implications for various diseases. However, more studies are necessary to fully understand its efficacy and safety profile.

Applications 17α-Boldenone is the 17α-epimer and metabolite of the anabolic steroid Boldenone (B675100). References Van Puymbroeck, M., et al.: Analyst, 123, 2681 (1998); Ferretti, G., et al.: Anal. Chim. Acta, 589, 269 (2007);

Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) is an inactive metabolite of progesterone by reduction at C5, C3, and C20 position.