Steroids

Pregna-4,8-diene-3,20-dione is a synthetic corticosteroid, which is an analog of naturally occurring hormones produced by the adrenal cortex. This compound is synthesized through complex chemical pathways utilizing steroidal intermediates to produce a substance with potent biological activity. The mode of action of Pregna-4,8-diene-3,20-dione involves its ability to alter the transcription of certain genes by binding to glucocorticoid receptors. This interaction induces the synthesis of proteins that inhibit the inflammatory response and suppress the immune system. Pregna-4,8-diene-3,20-dione is utilized in a variety of clinical applications, primarily for its anti-inflammatory and immunosuppressive properties. It is commonly employed in the treatment of conditions such as arthritis, allergic reactions, and autoimmune disorders. Additionally, it may be used as a component in combination therapies to reduce inflammation in more severe medical cases. Researchers continue to explore its potential in various other therapeutic areas, aiming to exploit its molecular characteristics to address complex medical challenges.

Estrone-3-Glucuronide sodium hydrate is the main metabolite of estrone, serving as a biological marker for gender identification in Andrias davidianus.

Applications Mometasone-d5 is the Isotope labelled analogue of Mometasone (M489995), a potent topical corticosteroid. Mometasone has potent antiinflammatory activity and is used in the treatment of dermatological disorders. References Schulz, M. et al.: Pharm. Zeit., 139, 28 (1994); Prakash, A. et al.: Drugs, 55, 145 (1998);

Cholestenone ((+)-4-Cholesten-3-one) is an intestinal metabolite of Cholesterol. It shows an anti-obesity effect on animals.

Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents.

Applications A metabolite of catecholamines. References Canfell, P., et al.: Clin. Chem., 32, 222 (1986), Nunez, C., et al.: Eur. J .Clin. Chem. Clin. Biochem., 32, 461 (1994), Weise, M., et al.: J. Clin. Endocrinol. Metab., 87, 1955 (2002),

Applications Flunisolide is a synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chu, N.I., et al.: Drug Metab. Dispos., 7, 81 (1979), Pakes, G.E., et al.: Drugs, 19, 397 (1980)

Asparanin B is a natural compound, which is a specialized saponin derived from the roots of asparagus plants, specifically from Asparagus officinalis. It exerts its effects through the modulation of cellular pathways, including the inhibition of cell proliferation, induction of apoptosis, and disruption of key signaling mechanisms involved in cancer development and progression. As a result, Asparanin B is being studied for its potential anticancer properties. In experimental settings, Asparanin B has demonstrated promising outcomes in the reduction of tumor growth and the enhancement of chemotherapy efficacy. Its mode of action encompasses the regulation of crucial molecules such as caspases and cyclins, which are integral to the cell cycle and apoptotic processes. Researchers are exploring its applications in oncology, aiming to harness its biological activity for therapeutic interventions. Furthermore, the minimal cytotoxicity observed in normal cells has spurred interest in its development as a targeted cancer therapy. Ongoing investigations continue to elucidate its full potential and mechanisms, shedding light on the diverse pharmacological applications of plant-derived compounds in modern medicine.