Steroids

Applications A labelled anabolic steroid.Controlled substance (anabolic steroid). References Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990), Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008),

Stability Hygroscopic Applications Glycocholic Acid Sodium Salt is a biochemical formed by the conjugation of cholic acid (C432600) with glycine (G615990). References Monalisa, M., et al.: Langmuir, 27 (2011);

Ophiopogonin D is a steroidal glycoside, which is a secondary metabolite sourced from the plant Ophiopogon japonicus. This compound is characterized by its presence in the roots, commonly referred to as radix Ophiopogonis, and is part of the broader group of ophiopogonins. Its mode of action primarily involves exerting anti-inflammatory and antioxidant effects. Ophiopogonin D has been shown to modulate signaling pathways that influence cellular oxidative stress and inflammatory responses, which are key in various pathological conditions. The uses and applications of Ophiopogonin D are diverse, extending to both traditional and modern pharmacological contexts. In traditional Chinese medicine, this compound is utilized for its purported benefits in cardiovascular health and respiratory functions. In contemporary research, Ophiopogonin D is being investigated for its potential neuroprotective effects and its role in modulating glucose metabolism, with implications for treating neurodegenerative diseases and diabetes. Its multifunctional properties make it a subject of interest for developing novel therapeutic agents targeting oxidative and inflammatory pathways.

Impurity Rocuronium EP Impurity A Applications (2β,3α,5α,16β,17β)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane (Rocuronium EP Impurity A) is a compound is used in the synthesis of the neuromuscular blocking agent rocuronium bromide. References Srinivasan, N. et al.: Orient. J. Chem., 24, 989 (2008);

1. Pseudoprotodioscin has moderate cytotoxicity.

Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.

Coumestrol is a phytoestrogen compound, which is a naturally occurring compound found in a variety of plants, such as soybeans, clover, and alfalfa. It is derived from the metabolic processes within these plants. Coumestrol exhibits estrogenic activity, acting as an agonist for estrogen receptors. This biological activity enables coumestrol to mimic the action of endogenous estrogens, thereby influencing estrogen-responsive pathways. Researchers extensively study coumestrol for its potential effects on human health, particularly in understanding estrogenic impact in various physiological processes. It is of interest in exploring alternatives to hormone replacement therapies and in cancer research, especially concerning breast and prostate cancers. Due to its ability to interact with estrogen receptors, there is significant interest in understanding how it may modulate hormonal balances and contribute to health outcomes in both preclinical and clinical settings.

Applications Epoxy Metradiene is an impurity from synthesis of Fluorometholone (F593145),a glucocorticoid; anti-inflammatory. References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982); Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984);

Applications Melengestrol Acetate derivative, an orally active progestational steroid. References Patton, M., et al.: Zoo Biol., 26, 311(2007), Sellin, M., et al.: Environ. Toxicol. Chem., 28, 2443 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Sanseverino, J., et al.: Toxicol. Sci., 107, 122 (2009),