Lignans

Veraguensin is derived from Magnolia sp.. Veraguensin inhibits bone resorption and shows high antileishmanial activity.

Ether alcohol phenol

Oxygen-heterocyclic compound

(-)-Syringaresinol is a naturally occurring lignan, which is a type of polyphenolic compound. It is predominantly sourced from plant materials, including certain seeds, roots, and bark of various plants such as those in the Oleaceae family. The compound acts primarily as an antioxidant, scavenging free radicals and reducing oxidative stress in biological systems. The uses and applications of (-)-Syringaresinol are extensive in the field of scientific research due to its potential therapeutic benefits. It is studied for its anti-inflammatory, anticancer, and neuroprotective properties. Researchers utilize (-)-Syringaresinol to explore its mechanisms in modulating immune responses and its potential role in preventing degenerative diseases. Given its diverse biological activities, it serves as a valuable compound in pharmacological studies and for developing botanical supplements.

Magnolin is a bioactive compound, which is a lignan isolated from the plant Magnolia officinalis. It functions as a natural product with various modes of action, primarily interacting with multiple signaling pathways in biological systems. Magnolin primarily inhibits the phosphorylation of key proteins involved in processes such as inflammation and cancer cell proliferation. The current research into Magnolin has highlighted its potential applications in the biomedical field, particularly in the development of anti-inflammatory and anticancer therapies. By regulating critical pathways, Magnolin can reduce the expression of pro-inflammatory cytokines and interfere with the growth cycle of tumor cells. Additionally, its antioxidant properties are of interest in neuroprotective research, suggesting potential benefits in treating neurodegenerative diseases. Such applications make Magnolin a significant focus of study for its therapeutic potential. Scientists are actively investigating its role and efficacy, aiming to better understand its medicinal properties and uncover its full range of biological activities.

Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).

Schisandrin (Wuweizi alcohol-A) is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.

(+)-Pinoresinol analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

4'-Demethylepipodophyllotoxin is a semisynthetic lignan, derived from the toxin podophyllotoxin, which is extracted from the roots and rhizomes of Podophyllum species, such as Podophyllum peltatum. The compound acts primarily as a topoisomerase II inhibitor. By binding to and stabilizing the enzyme-DNA complex, it prevents the re-ligation of DNA strands, which ultimately leads to breaks in the DNA and triggers apoptosis in rapidly dividing cancer cells. This lignan has significant applications in oncology, primarily used as a precursor in the synthesis of chemotherapeutic agents like etoposide and teniposide. These derivatives exhibit enhanced solubility and bioavailability compared to the parent compound, making them more suitable for clinical use. They are particularly effective in the treatment of various cancers, including small cell lung cancer, testicular cancer, and lymphomas. Extensive research is ongoing to explore its potential in novel therapeutic regimens and its effectiveness in combination with other anticancer agents, aiming to improve patient outcomes through synergistic effects and reduced resistance.