Flavonoids

8,3'-Dihydroxydaidzein is a naturally occurring isoflavonoid compound, which is a type of phytoestrogen predominantly found in soy and other leguminous plants. This compound is biosynthesized through the pathways involving the hydroxylation of daidzein, a well-known isoflavone. As a phytoestrogen, 8,3'-Dihydroxydaidzein mimics estrogenic activity by binding to estrogen receptors, thereby influencing various physiological processes in organisms. In research settings, 8,3'-Dihydroxydaidzein is studied for its antioxidant properties, where it plays a role in neutralizing free radicals, thus potentially reducing oxidative stress and damage at the cellular level. Its estrogenic activity allows it to modulate several biological pathways, offering potential therapeutic benefits in hormone-related conditions. The applications of 8,3'-Dihydroxydaidzein are explored in areas such as cancer research, particularly in understanding its effects on hormone-dependent cancers. Additionally, its antioxidative capabilities open avenues for studying its role in mitigating oxidative stress-related diseases. Being a naturally derived compound, it serves as a model for investigating plant-based interventions in various health-related scenarios.

Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.

Naringenin-7-glucoside is a flavonoid glycoside, which is primarily sourced from citrus fruits and certain herbs. This compound is a glucoside derivative of naringenin, a type of flavanone commonly found in a variety of plant species. With its distinct chemical structure, Naringenin-7-glucoside exerts its effects primarily through antioxidant and anti-inflammatory mechanisms. The compound works by scavenging free radicals and modulating cell signaling pathways, thereby reducing oxidative stress and inflammation at the cellular level. Naringenin-7-glucoside has diverse applications in scientific research and potential therapeutic settings. It is studied for its potential role in reducing the risk of chronic diseases such as cardiovascular disorders, diabetes, and certain forms of cancer. Researchers are also exploring its effects on metabolic pathways and its potential neuroprotective properties. Due to its involvement in intricate biochemical pathways, Naringenin-7-glucoside continues to be a subject of interest in pharmacological and nutraceutical studies.

Baicalein-5,6,7-trimethylether analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Isorhamnetin-3-O-b-D-glucoside is a flavonoid glycoside, which is typically extracted from various plant sources, notably from fruits and medicinal herbs like sea buckthorn and Ginkgo biloba. This compound is recognized for its role in modulating oxidative stress due to its antioxidant capabilities. The glycoside linkage enhances the solubility and bioavailability compared to the aglycone, isorhamnetin. The mode of action of isorhamnetin-3-O-b-D-glucoside involves scavenging free radicals and chelating metal ions, thereby mitigating oxidative damage in biological systems. This molecular activity is crucial for protecting cells against oxidative stress-induced damage, which is implicated in various diseases and aging processes. In terms of applications, isorhamnetin-3-O-b-D-glucoside is chiefly explored in the context of pharmaceutical and nutraceutical research, with studies focusing on its potential protective effects against cardiovascular diseases, inflammatory disorders, and certain types of cancer. Additionally, its role in modulating signaling pathways makes it a subject of interest in cell biology and therapeutic development studies.

Procyanidin B2 (PB2) is a naturally occurring flavonoid widely found in cocoa, red wine and grape juice, PB2 could protect against oxidative stress- and chemical-induced injury in colonic cells by modulating the endogenous cellular defence, PB2 protects against oxidative injury in colonic cells and up-regulate the expression of GSTP1 via a mechanism that involves ERK and p38 MAPK activation and Nrf2 translocation.

Tricetin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Oxygen-heterocyclic compound

Flavanomarein is a flavonoid compound, which is derived from the tea plant, Camellia sinensis. This compound is part of the broader family of polyphenolic flavonoids, which are secondary metabolites commonly found in various plants. Flavanomarein exerts its effects primarily through its antioxidant properties. The flavonoid can scavenge free radicals and inhibit oxidative stress, which are critical functions in preventing cellular damage and maintaining homeostasis. Additionally, flavanomarein may modulate various signaling pathways that are involved in inflammation and apoptosis, offering potential therapeutic benefits. Flavanomarein has captured scientific interest due to its possible applications in health and disease management. Its antioxidant capability has been explored in the context of chronic disease prevention, including cardiovascular and neurodegenerative diseases. Researchers are investigating its efficacy and molecular interactions in various preclinical models to elucidate its therapeutic potential. Understanding the exact mechanisms and benefits of flavanomarein could open up new avenues in nutraceutical development and integrative medicine.

Ternatin B is a naturally derived compound, which is a cyclic peptide sourced from plant-based materials. It functions predominantly by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1), a critical pathway involved in the regulation of cell growth and autophagy. This mode of action positions Ternatin B as a potent inhibitor of autophagy, the cellular process responsible for the degradation and recycling of cellular components. In scientific research, Ternatin B is utilized to study cellular processes, particularly to explore the therapeutic potential of autophagy modulation in various diseases. It has shown promise in oncology research, where its ability to alter mTORC1 activity is leveraged to assess its impact on cancer cell growth and survival. Moreover, Ternatin B serves as a valuable tool in studies aiming to understand metabolic regulation and stress responses in cells. With its specific inhibition of autophagy, Ternatin B provides insights into the development of novel therapeutic strategies for diseases characterized by dysregulated autophagy, such as neurodegenerative disorders and certain metabolic conditions.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3,7,4-Trihydroxy-5-methoxy-8-prenylflavanone, (2R,3S), is a prenylated flavanone, which is a type of polyphenolic compound. This compound is typically derived from various plant sources, particularly those that produce flavonoids as secondary metabolites. Its structure is characterized by the presence of hydroxyl and methoxy groups, as well as a prenylated side chain, which contribute to its physicochemical properties. The mode of action of 3,7,4-Trihydroxy-5-methoxy-8-prenylflavanone involves its interaction with biological targets through antioxidant, enzyme inhibition, or receptor modulation activities. This allows it to exert potential anti-inflammatory, antimicrobial, or anticancer effects, though the exact mechanisms may vary depending on the biological system under investigation. Its uses and applications are primarily in the field of medicinal chemistry and pharmacology, where it is studied for its potential therapeutic effects. Researchers may explore its efficacy in disease models or its role as a lead compound for drug development. The prenylated nature of this flavanone enhances its solubility and bioavailability, making it a subject of interest in the design of novel therapeutic agents.

Stability Hygroscopic Applications Diosmetin 3’,7-Diglucuronide is a metabolite of Diosmetin (D485000) which is a flavonoid often administered in the treatment of chronic venous insufficiency, hemorrhoids, and related affections. References Silverstro, L., et al.: Anal. Bioanal. Chem., 405, 8295 (2013); Boutin, J., et al.; Drug Metab. Dispos., 21, 1157 (1993)

Leucoside is a biochemical compound, which is derived from activated human leucocytes. This product is obtained through a meticulous extraction process that isolates specific bioactive molecules. Its mode of action involves the modulation of immune responses, potentially by influencing cytokine signaling pathways. Leucoside interacts with immune cells, potentially enhancing or dampening specific activities to achieve desired immunomodulatory effects. Applications of Leucoside are primarily within the field of immunological research. It is employed in studies investigating immune modulation, with additional uses in experimental therapeutics where modulation of immune response is crucial. Its potential to impact inflammation and immune regulation makes it a valuable tool for researchers focused on autoimmune diseases, chronic inflammatory conditions, and even in exploring novel cancer therapies. By serving as a model for understanding immune mechanisms, Leucoside contributes to the advancement of immunological science and therapeutic development.