Flavonoids

7,4'-Dibenzyl daidzein is a synthetic isoflavonoid, derived from the modification of natural isoflavones commonly found in soy products. These isoflavones are known for their estrogenic activity and potential therapeutic benefits. The source of inspiration for this compound lies in natural phytoestrogens, which exhibit significant interaction with human estrogen receptors. This synthetic analog is designed to enhance specific bioactivities beyond those of its natural counterparts. The mode of action of 7,4'-Dibenzyl daidzein involves its interaction with estrogen receptors, exhibiting both agonistic and antagonistic effects depending on the receptor subtype and cellular context. This dual modulatory behavior allows it to influence pathways related to cell proliferation and apoptosis, making it a candidate for anti-cancer research, particularly in hormone-responsive cancers such as breast and prostate cancer. It is utilized primarily in the research and development sector, focusing on understanding its mechanistic pathways and potential therapeutic applications. Its role in modulating estrogenic activity positions it as a valuable probe in studying estrogen receptor-related pathways, paving the way for potential drug development targeting hormone-related diseases.

Citrus bioflavonoids are a complex of compounds, which are derived from the peel and pulp of citrus fruits such as oranges, lemons, and grapefruits. These bioflavonoids function primarily as antioxidants, neutralizing free radicals and reducing oxidative stress within biological systems. By supporting the integrity of cellular structures, they contribute to the maintenance of optimal physiological conditions. The mode of action of citrus bioflavonoids involves modulation of several enzymatic pathways, aiding in vascular health by strengthening capillaries and regulating blood flow. Moreover, they exhibit anti-inflammatory properties by influencing cellular signaling mechanisms that are crucial in the inflammatory response. In scientific and clinical settings, citrus bioflavonoids are leveraged for their potential therapeutic applications. They are frequently studied for their role in cardiovascular health, immune support, and as adjuncts in enhancing the bioavailability of vitamin C. Their diverse applications extend to nutritional supplements and natural remedies designed to boost overall health and resilience against stress-related cellular damage. Their efficacy continues to be a subject of interest in ongoing research focused on chronic disease prevention and management.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2',3'-Dimethoxy-3-hydroxyflavone is a specialized flavonoid compound, which is synthesized and not typically found in natural sources. As a flavonoid derivative, this compound is formed through chemical modification of naturally occurring flavones, a class of polyphenolic compounds recognized for their diverse biological activities. With a structure characterized by methoxy and hydroxyl groups, this compound exhibits unique interactions at the molecular level. The mode of action of 2',3'-Dimethoxy-3-hydroxyflavone primarily involves its ability to act as an antioxidant. It is known to scavenge reactive oxygen species and inhibit oxidative stress pathways, making it of interest in the study of cellular protection mechanisms. Moreover, its structural features allow it to interact with various biological molecules, potentially modulating signaling pathways within cells. Applications of this compound are primarily in research contexts, where it is utilized to explore its effects on oxidative stress-related conditions and its potential role in modulating enzymatic activities and cellular signaling. Its ability to influence biological pathways makes it a valuable tool in pharmacological and biochemical research, where it aids in the understanding of flavonoid interactions and their therapeutic potentials.

Natural glycoside

4-Hydroxycoumarin: precursor to 4HC anticoagulants like warfarin; has anticoagulant, antibacterial, antiviral, and anticancer properties.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Zapotin is a natural compound, which is sourced from the seeds of the Sapote Blanco (Casimiroa edulis). This organic compound exhibits its mode of action primarily through its interaction with cancerous cells. Zapotin induces apoptosis in these cells by modulating key signaling pathways, thereby preventing cell proliferation and enhancing programmed cell death. This mechanism underscores its potential as a chemopreventive agent. The primary uses and applications of Zapotin are centered around its anticancer properties. It has been extensively studied for its effects against various cancer types, including colon cancer, where it has shown promising ability to inhibit tumor growth. Additionally, its antioxidant properties further contribute to cellular protection against oxidative stress, which is often implicated in cancer development. Researchers continue to investigate the broader applications of Zapotin, exploring its utility in integrative cancer therapies and its potential synergistic effects when used in combination with other chemotherapeutic agents. Although more studies are needed to fully understand its efficacy and safety profile, Zapotin represents a promising avenue for future oncological research.

Gardenin B is a microbial biocontrol agent that originates from Streptomyces bacteria. It functions as a secondary metabolite deriving from its microbial source. The mode of action involves inhibiting the growth of plant-pathogenic fungi by disrupting their cellular processes and interfering with spore germination or hyphal proliferation. Gardenin B is primarily utilized in agricultural settings to control fungal diseases in crops, reducing reliance on synthetic chemical fungicides. Its application is integrated into plant protection programs to enhance agricultural sustainability and improve crop yields while minimizing the environmental impact. Scientists are investigating its mechanisms and potential for broader applications.

Narcissin is a flavonoid glycoside, which is a bioactive compound isolated from the Narcissus species, particularly found in various plant parts of the genus Narcissus. The source of narcissin is primarily within the botanical family Amaryllidaceae, known for its diverse metabolic profile and prominent ornamental species. Narcissin exerts its mode of action through its role as an antioxidant. It scavenges free radicals and inhibits oxidative stress pathways, which is crucial in cellular protection against reactive oxygen species (ROS). This mechanism is fundamental to its ability to preserve cellular integrity and prevent lipid peroxidation, thus supporting cellular homeostasis. The uses and applications of narcissin are primarily in the field of pharmacology and nutritional sciences. It is extensively studied for its potential therapeutic benefits, including its role in mitigating inflammation and reducing the risk of chronic diseases related to oxidative stress, such as cardiovascular diseases and neurodegenerative disorders. Additionally, narcissin's potential as a natural antioxidant makes it a candidate for inclusion in nutraceutical formulations aimed at promoting health and longevity.

8-Hydroxy-7-methoxyflavone is a naturally occurring flavonoid compound, which is isolated from various plant sources known for their bioactive properties. Flavonoids are a diverse group of phytonutrients found in many fruits, vegetables, and other plants, and are well-studied for their roles in plant pigmentation and health benefits. The mode of action for 8-Hydroxy-7-methoxyflavone involves modulating various biochemical pathways, particularly acting as an agonist of the TrkB receptor, which is associated with the regulation of neuronal growth and survival. This interaction suggests that the compound can significantly influence neurotrophic signaling pathways, which are crucial for neuroprotection and cognitive enhancement. Research into the uses and applications of 8-Hydroxy-7-methoxyflavone indicates its potential in developing therapeutics for neurological conditions, such as neurodegenerative diseases and cognitive disorders. Due to its ability to activate key receptors involved in brain health, this flavonoid presents promising therapeutic avenues for enhancing synaptic plasticity and promoting neuron differentiation. However, further studies are needed to fully elucidate its efficacy and safety profiles in clinical settings.

Oxygen-heterocyclic compound

Quercetin-3-arabinoglucoside is a flavonoid glycoside, which is a phytochemical derived primarily from a variety of plant sources, including fruits, vegetables, and medicinal plants. This compound acts as a potent antioxidant by scavenging free radicals, thereby protecting cells from oxidative stress, which can lead to cellular damage and various diseases. Quercetin-3-arabinoglucoside's primary uses and applications are in the fields of nutrition and pharmacology. It is studied for its potential health benefits, including anti-inflammatory, anti-allergic, and cardioprotective effects. The compound may modulate signal transduction pathways and gene expression, influencing cellular responses. It is also of interest in research concerning cancer, where it is being investigated for its ability to inhibit the proliferation of cancer cells and induce apoptosis. In addition, its role in immune system modulation is an area of ongoing research, with potential implications for enhancing immune responses.

Resokaempferol analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

7-Methoxyflavonol is a naturally-occurring flavonoid with intriguing biochemical properties, identified primarily in various plant species. This compound is derived from natural sources such as herbs and fruits, where it contributes to the plant's defense mechanisms. The mode of action of 7-Methoxyflavonol involves modulation of enzymatic activities and interaction with cellular signaling pathways, exhibiting potential antioxidant and anti-inflammatory effects. In scientific research, 7-Methoxyflavonol is utilized for its promising biological activities. Studies have suggested its role in scavenging free radicals and protecting cells from oxidative stress, which can be vital in understanding cellular aging and disease processes. Moreover, its anti-inflammatory properties are of interest for developing therapeutic strategies for conditions associated with inflammation. Ongoing research is focused on elucidating its molecular interactions and potential benefits in various medical and pharmacological applications. The exploration of this flavonoid could open new avenues in the development of natural health products and therapeutic agents.

Galangin analytical standard provided with w/w absolute assay, to be used for quantitative titration.